Discovery and SAR of 2-arylbenzotriazoles and 2-arylindazoles as potential treatments for Duchenne muscular dystrophy

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 16, 2011, Pages 4828-4831

  De Moor, Olivier ^a   Dorgan, Colin R ^a   Johnson, Peter D ^a   Lambert, Adam G ^a   Lecci, Cristina ^a   Maillol, Carole ^a   Nugent, Gary ^a   Poignant, Séverine D ^a   Price, Paul D ^a   Pye, Richard J ^a   Storer, Richard ^a   Tinsley, Jonathon M ^a   Vickers, Richard ^a   Well, Renate Van ^a   Wilkes, Fraser J ^a   Wilson, Francis X ^a   Wren, Stephen P ^a   Wynne, Graham M ^a  

^a SUMMIT PLC   (United Kingdom)

Author keywords

Benzotriazole; Duchenne; Dystrophy; Indazole; Muscular

Indexed keywords

2 ARYLBENZOTRIAZOLE DERIVATIVE; 2 ARYLINDAZOLE DERIVATIVE; 5 METHYLSULFONYL DERIVATIVE; BENZOTRIAZOLE DERIVATIVE; ETHYL SULPHONE DERIVATIVE; ISOPROPYL SULPHONE; METHYL SULPHONE; SULFONYL BENZOTRIAZOLE DERIVATIVE; TALTRIMIDE; UNCLASSIFIED DRUG; UTROPHIN;

ARTICLE; DRUG ACTIVITY; DRUG DEVELOPMENT; DRUG PURIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; DUCHENNE MUSCULAR DYSTROPHY; HUMAN; IN VITRO STUDY; MICROSOME; UPREGULATION;

DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HUMANS; INDAZOLES; MICROSOMES, LIVER; MOLECULAR STRUCTURE; MUSCULAR DYSTROPHY, DUCHENNE; SOLUBILITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 79960918733     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.06.047     Document Type: Article

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