A multicenter, randomized trial comparing heparin/warfarin and acetylsalicylic acid as primary thromboprophylaxis for 2 years after the Fontan procedure in children

Journal of the American College of Cardiology

Volumn 58, Issue 6, 2011, Pages 645-651

  Monagle, Paul ^a   Cochrane, Andrew ^a   Roberts, Robin ^c   Manlhiot, Cedric ^b   Weintraub, Robert ^a   Szechtman, Barbara ^c   Hughes, Marina ^d   Andrew, Maureen ^b   McCrindle, Brian W ^b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c MCMASTER UNIVERSITY   (Canada)

^d GREAT ORMOND STREET HOSPITAL   (United Kingdom)

Author keywords

anticoagulation; Fontan procedure; pediatrics; thrombosis

Indexed keywords

ACETYLSALICYLIC ACID; HEPARIN; WARFARIN;

ARTICLE; BLEEDING; CHILD; CONTROLLED STUDY; FEMALE; FONTAN PROCEDURE; GASTROINTESTINAL HEMORRHAGE; HUMAN; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTICENTER STUDY; PATIENT COMPLIANCE; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; THROMBOSIS; TRANSESOPHAGEAL ECHOCARDIOGRAPHY; TREATMENT OUTCOME;

ANTICOAGULANTS; ASPIRIN; CHILD; CHILD, PRESCHOOL; ECHOCARDIOGRAPHY; FEMALE; FONTAN PROCEDURE; HEPARIN; HUMANS; INTERNATIONAL COOPERATION; MALE; THROMBOEMBOLISM; THROMBOSIS; TREATMENT OUTCOME; WARFARIN;

EID: 79960909667     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2011.01.061     Document Type: Article

References (19)

1. P. Monagle, A. Cochrane, B. McCrindle, L. Benson, W. Williams, and M. Andrew Thromboembolic complications after fontan procedures - the role of prophylactic anticoagulation J Thorac Cardiovasc Surg 115 1998 493 498 (Pubitemid 28158063)
2. F. Cetta, R.H. Feldt, and P.W. O'Leary Improved early morbidity and mortality after Fontan operation: the Mayo Clinic experience, 1987 to 1992 J Am Coll Cardiol 28 1996 480 486 (Pubitemid 26274347)
3. D.J. Driscoll, K.P. Offord, R.H. Feldt, H.V. Schaff, F.J. Puga, and G.K. Danielson Five- to fifteen-year follow-up after Fontan operation Circulation 85 1992 469 496
4. A.W. Gale, G.K. Danielson, D.C. McGoon, and D.D. Mair Modified Fontan operation for univentricular heart and complicated congenital lesions J Thorac Cardiovasc Surg 78 1979 831 838 (Pubitemid 10171608)
5. P. Khairy, S.M. Fernandes, and J.E. Mayer Jr. Long-term survival, modes of death, and predictors of mortality in patients with Fontan surgery Circulation 117 2008 85 92 (Pubitemid 350291185)
6. M. Ono, D. Boethig, H. Goerler, M. Lange, M. Westhoff-Bleck, and T. Breymann Clinical outcome of patients 20 years after Fontan operationeffect of fenestration on late morbidity Eur J Cardiothorac Surg 30 2006 923 929 (Pubitemid 44738628)
7. J.S. Tweddell, M. Nersesian, and K.A. Mussatto Fontan palliation in the modern era: factors impacting mortality and morbidity Ann Thorac Surg 88 2009 1291 1299
8. P. Monagle, and T.R. Karl Thromboembolic problems after the Fontan operation Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 5 2002 36 47 (Pubitemid 38202149)
9. G. Balling, M. Vogt, H. Kaemmerer, A. Eicken, H. Meisner, and J. Hess Intracardiac thrombus formation after the Fontan operation J Thorac Cardiovasc Surg 119 2000 745 752 (Pubitemid 30395472)
10. D.A. Fyfe, C.H. Kline, R.M. Sade, and P.C. Gillette Transesophageal echocardiography detects thrombus formation not identified by transthoracic echocardiography after the Fontan operation J Am Coll Cardiol 18 1991 1733 1737
11. O. Stumper, G.R. Sutherland, R. Geuskens, J.R. Roelandt, E. Bos, and J. Hess Transesophageal echocardiography in evaluation and management after a Fontan procedure J Am Coll Cardiol 17 1991 1152 1160
12. R.G. Seipelt, A. Franke, and J.F. Vazquez-Jimenez Thromboembolic complications after Fontan procedures: comparison of different therapeutic approaches Ann Thorac Surg 74 2002 556 562 (Pubitemid 34838867)
13. D.G. Wilson, J.D. Wisheart, and A.G. Stuart Systemic thromboembolism leading to myocardial infarction and stroke after fenestrated total cavopulmonary connection Br Heart J 73 1995 483 485
14. A.M. Tan, A.J. Iyengar, and S. Donath Fontan completion rate and outcomes after bidirectional cavo-pulmonary shunt Eur J Cardiothorac Surg 38 2010 59 65
15. Y. d'Udekem, A.J. Iyengar, and A.D. Cochrane The Fontan procedure: contemporary techniques have improved long-term outcomes Circulation 116 2007 I157 I164
16. C.B. Mahnke, G.J. Boyle, J.E. Janosky, R.D. Siewers, and F.A. Pigula Anticoagulation and incidence of late cerebrovascular accidents following the Fontan procedure Pediatr Cardiol 26 2005 56 61 (Pubitemid 41569562)
17. F. Newall, H. Savoia, J. Campbell, and P. Monagle Anticoagulation clinics for children achieve improved warfarin management Thromb Res 114 2004 5 9 (Pubitemid 38942969)
18. W. Streif, M. Andrew, and V. Marzinotto Analysis of warfarin therapy in pediatric patients: a prospective cohort study of 319 patients Blood 94 1999 3007 3014 (Pubitemid 29512704)
19. A.D. Michelson, M. Cattaneo, and J.W. Eikelboom Aspirin resistance: position paper of the Working Group on Aspirin Resistance J Thromb Haemost 3 2005 1309 1311 (Pubitemid 41725257)