Nuclear localization of maspin is essential for its inhibition of tumor growth and metastasis

Laboratory Investigation

Volumn 91, Issue 8, 2011, Pages 1181-1187

  Goulet, Brigitte ^a   Kennette, Wendy ^a   Ablack, Amber ^a   Postenka, Carl O ^a   Hague, M Nicole ^a   Mymryk, Joe S ^a,b   Tuck, Alan B ^a,b   Giguère, Vincent ^c   Chambers, Ann F ^a,b   Lewis, John D ^a,b  

^a LONDON REGIONAL CANCER PROGRAM   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

breast cancer; chromatin immunoprecipitation; maspin; metastasis; nuclear localization

Indexed keywords

COLONY STIMULATING FACTOR 1; ESTROGEN RELATED RECEPTOR ALPHA; MASPIN; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CANCER INVASION; CARCINOGENESIS; CELL NUCLEUS; CELLULAR DISTRIBUTION; CHICKEN; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; EMBRYO; FEMALE; GENE CONTROL; GENE FUNCTION; GENE TARGETING; HUMAN; HUMAN CELL; IN VIVO STUDY; METASTASIS INHIBITION; MOUSE; NONHUMAN; NUCLEAR EXCLUSION SIGNAL; NUCLEAR EXPORT SIGNAL; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN STRUCTURE; SQUAMOUS CELL CARCINOMA; XENOGRAFT;

ANIMALS; BREAST NEOPLASMS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL NUCLEUS; CHROMATIN; FEMALE; HUMANS; MACROPHAGE COLONY-STIMULATING FACTOR; MICE; MICE, NUDE; NEOPLASM METASTASIS; PROMOTER REGIONS, GENETIC; SERPINS;

EID: 79960908488     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2011.66     Document Type: Article

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