Synthesis of antitrypanosomal 1,2-dioxane derivatives based on a natural product scaffold

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 16, 2011, Pages 4793-4797

  Holla, Harish ^a   Labaied, Mehdi ^b   Pham, Ngoc ^a   Jenkins, Ian D ^a   Stuart, Kenneth ^b   Quinn, Ronald J ^a  

^a GRIFFITH UNIVERSITY   (Australia)

^b Seattle BioMed   (United States)

Author keywords

1,2 Dioxane; Antitrypanosomal; Ene reaction; HAT; Natural product scaffold

Indexed keywords

1,2 DIOXANE DERIVATIVE; ANTITRYPANOSOMAL AGENT; NATURAL PRODUCT; PHOSPHORUS; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STABILITY; DRUG SYNTHESIS; NONHUMAN; OZONOLYSIS; PARTICLE SIZE; WITTIG REACTION;

ANIMALS; BIOLOGICAL FACTORS; DIOXANES; DOSE-RESPONSE RELATIONSHIP, DRUG; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PLAKORTIS; SMALL MOLECULE LIBRARIES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI;

PLAKORTIS;

EID: 79960908275     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.06.059     Document Type: Article

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