Gene expression of carnitine organic cation transporters 1 and 2 (OCTN) is downregulated in patients with ulcerative colitis

Inflammatory Bowel Diseases

Volumn 17, Issue 10, 2011, Pages 2205-2206

  Yamamoto Furusho, Jesús K ^a   Mendivil Rangel, Edgar J ^a   Villeda Ramírez, Marco A ^a   Fonseca Camarillo, Gabriela ^a   Barreto Zuñiga, Rafael ^a  

^a INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 2;

COLON BIOPSY; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; HUMAN; INTESTINE MUCOSA PERMEABILITY; LETTER; MAJOR CLINICAL STUDY; PATHOGENESIS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REMISSION; ULCERATIVE COLITIS;

CASE-CONTROL STUDIES; COLITIS, ULCERATIVE; COLON; GENE EXPRESSION; HUMANS; ORGANIC CATION TRANSPORT PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; REMISSION INDUCTION; RNA, MESSENGER;

EID: 79960883159     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.21621     Document Type: Letter

References (6)

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2. Waller S, Tremelling M, Bredin F, et al. Evidence for association of OCTN genes and IBD5 with ulcerative colitis. Gut. 2006; 55: 809-814.
3. -/-) mice. Mol Genet Metab. 2007; 92: 315-324.
4. D'Argenio G, Calvani M, Casamassimi A, et al. Experimental colitis: decreased Octn2 and Atb0+ expression in rat colonocytes induces carnitine depletion that is reversible by carnitine-loaded liposomes. FASEB J. 2006; 20: 2544-2546.
5. Peltekova VD, Wintle RF, Rubin LA, et al. Functional variants of OCTN cation transporter genes are associated with Crohn disease. Nat Genet. 2004; 36: 471-475.
6. Noble CL, Abbas AR, Cornelius J, et al. Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis. Gut. 2008; 57: 1398-1405.