Antiviral activity and mechanism of action of novel thiourea containing chiral phosphonate on tobacco mosaic virus

International Journal of Molecular Sciences

Volumn 12, Issue 7, 2011, Pages 4522-4535

  Fan, Huitao ^a   Song, Baoan ^a   Bhadury, Pinaki S ^a   Jin, Linhong ^a   Hu, Deyu ^a   Yang, Song ^a  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Antiviral activity; Chiral thiourea compounds; Mechanism of action; Tobacco mosaic virus

Indexed keywords

ANTIVIRUS AGENT; CAPSID PROTEIN; CHLOROPHYLL; NINGNANMYCIN; O,O' DIISOPROPYL [3 [1 (BENZYLAMINO) 1 OXO 3 PHENYLPROPAN 2 YL]THIOUREIDO]PHENYLMETHYL PHOSPHONIC ACID; PEROXIDASE; PHENYLALANINE AMMONIA LYASE; SUPEROXIDE DISMUTASE; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG; CYTIDINE; O,O'-DIISOPROPYL (3-(L-1-(BENZYLAMINO)-1-OXO-3-PHENYLPROPAN-2-YL)THIOUREIDO)(PHENYL)METHYLPHOSPHONATE; PHOSPHONIC ACID DERIVATIVE; THIOUREA;

ANTIVIRAL ACTIVITY; ANTIVIRAL RESISTANCE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; INOCULATION; LEAF SPOT; NONHUMAN; POLYMERIZATION; TOBACCO; TOBACCO MOSAIC VIRUS; ANALOGS AND DERIVATIVES; CHEMISTRY; DRUG EFFECTS; METABOLISM; STEREOISOMERISM;

MIRIDAE; NICOTIANA OBTUSIFOLIA; NICOTIANA TABACUM; TOBACCO MOSAIC VIRUS;

ANTIVIRAL AGENTS; CAPSID PROTEINS; CHLOROPHYLL; CYTIDINE; ORGANOPHOSPHONATES; PEROXIDASE; PHENYLALANINE AMMONIA-LYASE; STEREOISOMERISM; SUPEROXIDE DISMUTASE; THIOUREA; TOBACCO MOSAIC VIRUS;

EID: 79960814430     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms12074522     Document Type: Article

References (15)

1. Wu, Y.F.; Cao, R.; Wei, N.S.; Zhou, G.H. Screening and application of biological pesticides virus. World Agr. 1995, 5, 35-36.
2. Gong, Y.X.; Wang, Z.Y.; Zhang, Y.; Wang, Y.G. N-[5-(trifluoromethyl phenyl)-1,3,4-thiadiazole-2-base]-N'-aryloxycarboxylic acetyl thiourea and biological activity. Chinese J. Syn. Chem. 2006, 14, 371-374.
3. Xue, S.J.; Duan, L.P.; Ke, S.Y.; Zhu, J.M. Synthesis and herbicidal activities of pentylchrsanthemacyl thiourea pyrimidine derivatives and related fuse ring compounds. Chinese J. Org. Chem. 2004, 24, 686-690.
4. Hyderabad, J.D.; Hyderabad, S.N.; Hyderabad, S.T. Anribacterial compounds: Process for their preparation and pharmaceutical compostions contaianing them. US Patent 7,202,254, 10 April 2007.
5. Zou, X.J.; Jin, G.Y.; Yang, Z. Synthesis of the thiosemicarbazides of 1-Aryl-1,4-dihydro-3-Carbox-6-methyl-4-pyridazinone and their antiviral activity against TMV. Chem. J. Chinese Univ. 2002, 23, 403-406.
6. Mao, J.M.; Zheng, A.Z.; Bai,Y.; Bai, B.Z. Some physiological-biochemical changes of tobacco leaves when infected by mosaic virus disease. J. Jilin Agr. Univ. 2002, 24, 19-21.
7. Jiang, S.; Guo, X.L.; Han, X.L. Influence of antiphytoviral substances on the polymerization (in vitro) of coat protein of Tobacco Mosaic Virus (TMV). Virologica Sinica 1996, 11, 77-79.
8. Pang, L.L.; Song, B.A.; Wang, H.; Jin, L.H. Laboratory determination of the toxic activity of ningnanmycin, virus A, and antofine against tobacco mosaic virus. Chinese J. Pescitides 2005, 44, 176-178.
9. Gooding, G. V.; Hebert, T.T.; A simple technique for purification of tobacco mosaic virus in large quanities. Phytopathology 1967, 57, 1285-1289.
10. Wu, Q.Y.; Cheng, X.H.; Ding, M.; Fang, Q.; Zhou, X.G.; Zhang, Z.K. Study on the fast diagnosis kit for tobacco mosaic virus with two kinds of ELISA. J. Central Chin. Normal Univ. 2000, 34, 468-470.
11. Xue, Y.L. Handbook of Plant Physiology Experiments; Shanghai Science and Technology Press: Shanghai, China, 1985; pp. 191-192.
12. Zhu, G.L. Plant Physiology; Science Press: Beijing, China, 1990; p. 37.
13. Wang, X.K. Plant Physiology and Biochemistry Principle and Technology; Higher Education Press: Beijing, China, 2006; pp. 167-168.
14. Peng, Y.S.; Liu, E. Studies of method on extract chlorophyll a and b. Acta Agric. Univ. Pekinensis 1992, 18, 247-250.
15. Fu, M.J.; Gao, Q.W.; Fan, H.Z. Studies on strains of TMV in tobacco production areas in guangdong province. Virol. Sinica 1997, 12, 254-259.