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Volumn 45, Issue 7-8, 2011, Pages

Busulfan and metronidazole: An often forgotten but significant drug interaction

Author keywords

Busulfan; Drug interactions; Metronidazole

Indexed keywords

BUSULFAN; CLOFARABINE; CYTOCHROME P450 3A4; GLUTATHIONE TRANSFERASE A1; LORAZEPAM; METRONIDAZOLE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; TACROLIMUS; THIOTEPA; ALKYLATING AGENT; ANTIINFECTIVE AGENT; MYELOABLATIVE AGENT;

EID: 79960791738     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1Q087     Document Type: Article
Times cited : (31)

References (16)
  • 1
    • 0030902219 scopus 로고    scopus 로고
    • Marrow transplantation for chronic myeloid leukemia: The influence of plasma busulfan levels on the outcome of transplantation
    • Slattery JT, Clift RA, Buckner CD, et al. Marrow transplantation for chronic myeloid leukemia: the influence of plasma busulfan levels on the outcome of transplantation. Blood 1997;89:3055-30560.
    • (1997) Blood , vol.89 , pp. 3055-30560
    • Slattery, J.T.1    Clift, R.A.2    Buckner, C.D.3
  • 2
    • 13344259305 scopus 로고    scopus 로고
    • Association of busulfan area under the curve with veno-occlusive disease following BMT
    • Dix S P, Wingard JR, Mullins RE, et al. Association of busulfan area under the curve with veno-occlusive disease following BMT. Bone Marrow Transplant 1996;17:225-230.
    • (1996) Bone Marrow Transplant , vol.17 , pp. 225-230
    • Dix, S.P.1    Wingard, J.R.2    Mullins, R.E.3
  • 3
    • 0036398471 scopus 로고    scopus 로고
    • Busulfan systemic exposure relative to regimen related toxicity and acute graft-versus-host disease: Defining a therapeutic window for i.v. BuCy2 in chronic myelogenous leukemia
    • Andersson BS, Thall PF, Madden T, et al. Busulfan systemic exposure relative to regimen related toxicity and acute graft-versus-host disease: defining a therapeutic window for i.v. BuCy2 in chronic myelogenous leukemia. Biol Blood Marrow Transplant 2002;8:477-485.
    • (2002) Biol Blood Marrow Transplant , vol.8 , pp. 477-485
    • Andersson, B.S.1    Thall, P.F.2    Madden, T.3
  • 4
    • 0034567061 scopus 로고    scopus 로고
    • Acute safety and pharmacoki-netics of intravenous busulfan when used with oral busulfan and cy-clophosphamide as pretransplantation conditioning therapy: A phase I study
    • Andersson BS, Madden T, Tran HT, et al. Acute safety and pharmacoki-netics of intravenous busulfan when used with oral busulfan and cy-clophosphamide as pretransplantation conditioning therapy: a phase I study. Biol Blood Marrow Transplant 2000;6:548-554.
    • (2000) Biol Blood Marrow Transplant , vol.6 , pp. 548-554
    • Andersson, B.S.1    Madden, T.2    Tran, H.T.3
  • 5
    • 33845984552 scopus 로고    scopus 로고
    • Pharmacokinetics of once-daily IV busulfan as part of pretransplantation preparative regimens: A comparison with an every 6-hour dosing schedule
    • DOI 10.1016/j.bbmt.2006.08.037
    • Madden T, de Lima M, Thapar N, et al. Pharmacokinetics of once-daily IV busulfan as part of pretransplantation preparative regimens: a comparison with an every 6-hour dosing schedule. Biol Blood Marrow Transplant 2007;13:56-64. DOI 10.1016/j.bbmt.2006.08.037
    • (2007) Biol Blood Marrow Transplant , vol.13 , pp. 56-64
    • Madden, T.1    de Lima, M.2    Thapar, N.3
  • 7
    • 0032744935 scopus 로고    scopus 로고
    • Up-regulation of glutathione S-transferase activity in enterocytes of young children
    • Gibbs JP, Liacouras CA, Baldassano RN, Slattery JT. Up-regulation of glutathione S-transferase activity in enterocytes of young children. Drug Metab Dispos 1999;27:1466-1469.
    • (1999) Drug Metab Dispos , vol.27 , pp. 1466-1469
    • Gibbs, J.P.1    Liacouras, C.A.2    Baldassano, R.N.3    Slattery, J.T.4
  • 8
    • 0242669388 scopus 로고    scopus 로고
    • The effect of metronidazole on busulfan pharmacokinetics in patients undergoing hematopoietic stem cell transplantation
    • DOI 10.1038/sj.bmt.1703896
    • Nilsson C, Aschan J, Hentschke P, Ringden O, Ljungman P, Hassan M. The effect of metronidazole on busulfan pharmacokinetics in patients undergoing hematopoietic stem cell transplantation. Bone Marrow Transplant 2003;31:429-435. DOI 10.1038/sj.bmt.1703896
    • (2003) Bone Marrow Transplant , vol.31 , pp. 429-435
    • Nilsson, C.1    Aschan, J.2    Hentschke, P.3    Ringden, O.4    Ljungman, P.5    Hassan, M.6
  • 9
    • 34247280999 scopus 로고    scopus 로고
    • Does metronidazole interact with CYP3A substrates by inhibiting their metabolism through this metabolic pathway? Or should other mechanisms be considered?
    • DOI 10.1345/aph.1H401
    • Roedler R, Neuhauser MM, Penzak SR. Does metronidazole interact with CYP3A substrates by inhibiting their metabolism through this metabolic pathway? Or should other mechanisms be considered? Ann Pharmacother 2007;41:653-658. DOI 10.1345/aph.1H401
    • (2007) Ann Pharmacother , vol.41 , pp. 653-658
    • Roedler, R.1    Neuhauser, M.M.2    Penzak, S.R.3
  • 10
    • 0036090053 scopus 로고    scopus 로고
    • Cytochrome P450 isoenzymes 3A4 and 2B6 are involved in the in vitro human metabolism of thiotepa to TEPA
    • DOI 10.1007/s00280-002-0453-3
    • Jacobson PA, Green K, Birnbaum A, Remmel RP. Cytochrome P450 isoenzymes 3A4 and 2B6 are involved in the in vitro human metabolism of thiotepa to TEPA. Cancer Chemother Pharmacol 2002;49:461-467. DOI 10.1007/s00280-002-0453-3
    • (2002) Cancer Chemother Pharmacol , vol.49 , pp. 461-467
    • Jacobson, P.A.1    Green, K.2    Birnbaum, A.3    Remmel, R.P.4
  • 11
    • 0036237885 scopus 로고    scopus 로고
    • Triethylenethiophospho-ramide is a specific inhibitor of cytochrome P450 2B6: Implications for cyclophosphamide metabolism
    • DOI 10.1124/dmd.30.5.525
    • Rae JM, Soukhova NV, Flockhart DA, Desta Z. Triethylenethiophospho-ramide is a specific inhibitor of cytochrome P450 2B6: implications for cyclophosphamide metabolism. Drug Metab Dispos 2002;30:525-530. DOI 10.1124/dmd.30.5.525
    • (2002) Drug Metab Dispos , vol.30 , pp. 525-530
    • Rae, J.M.1    Soukhova, N.V.2    Flockhart, D.A.3    Desta, Z.4
  • 12
    • 6444243739 scopus 로고    scopus 로고
    • Pharmacokinetics and individualized dose adjustment of intravenous busulfan in children with advanced hematologic malignancies undergoing allogeneic stem cell transplantation
    • DOI 10.1016/j.bbmt.2004.07.010
    • Tran H, Petropoulos D, Worth L, et al. Pharmacokinetics and individualized dose adjustment of intravenous busulfan in children with advanced hematologic malignancies undergoing allogeneic stem cell transplantation. Biol Blood Marrow Transplant 2004;10:805-812. DOI 10.1016/j.bbmt.2004.07.010
    • (2004) Biol Blood Marrow Transplant , vol.10 , pp. 805-812
    • Tran, H.1    Petropoulos, D.2    Worth, L.3
  • 13
    • 0034960016 scopus 로고    scopus 로고
    • Busulfan levels are influenced by prior treatment and are associated with hepatic veno-occlusive disease and early mortality but not with delayed complications following marrow transplantation
    • Copelan EA, Bechtel TP, Avalos BR, et al. Busulfan levels are influenced by prior treatment and are associated with hepatic veno-occlusive disease and early mortality but not with delayed complications following marrow transplantation. Bone Marrow Transplant 2001;27:1121-1124.
    • (2001) Bone Marrow Transplant , vol.27 , pp. 1121-1124
    • Copelan, E.A.1    Bechtel, T.P.2    Avalos, B.R.3
  • 14
    • 77953937672 scopus 로고    scopus 로고
    • Novel pharmacokinetic behavior of intravenous busulfan in children with thalassemia undergoing hematopoietic stem cell transplantation: A prospective evaluation of phar-macokinetic and pharmacodynamic profile with therapeutic drug monitoring
    • DOI 10.1182/blood-2010-01-265405
    • Gaziev J, Nguyen L, Puozzo C, et al. Novel pharmacokinetic behavior of intravenous busulfan in children with thalassemia undergoing hematopoietic stem cell transplantation: a prospective evaluation of phar-macokinetic and pharmacodynamic profile with therapeutic drug monitoring. Transplantation 2010;115:4597-4604. DOI 10.1182/blood-2010-01-265405
    • (2010) Transplantation , vol.115 , pp. 4597-4604
    • Gaziev, J.1    Nguyen, L.2    Puozzo, C.3
  • 15
    • 0035115017 scopus 로고    scopus 로고
    • Glutathione S-transferase activity influences busulfan pharmacokinet-ics in patients with beta thalassemia major undergoing bone marrow transplantation
    • Poonkuzhali B, Chandy M, Srivastava A, Dennison D, Krishnamoorthy R. Glutathione S-transferase activity influences busulfan pharmacokinet-ics in patients with beta thalassemia major undergoing bone marrow transplantation. Drug Metab Dispos 2001;29:264-267.
    • (2001) Drug Metab Dispos , vol.29 , pp. 264-267
    • Poonkuzhali, B.1    Chandy, M.2    Srivastava, A.3    Dennison, D.4    Krishnamoorthy, R.5
  • 16
    • 34247231457 scopus 로고    scopus 로고
    • Proposal for a new tool to evaluate drug interaction cases
    • DOI 10.1345/aph.1H423
    • Horn JR, Hansten PD, Chan L-N. Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother 2007;41:674-680. DOI 10.1345/aph.1H423
    • (2007) Ann Pharmacother , vol.41 , pp. 674-680
    • Horn, J.R.1    Hansten, P.D.2    Chan, L.-N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.