β-Adrenergic receptor blockade reduces endoplasmic reticulum stress and normalizes calcium handling in a coronary embolization model of heart failure in canines

Cardiovascular Research

Volumn 91, Issue 3, 2011, Pages 447-455

  George, Isaac ^a   Sabbah, Hani N ^b   Xu, Kai ^a   Wang, Nan ^a   Wang, Jie ^a,c  

^a Columbia University ^*  (United States)

^b HENRY FORD HEART AND VASCULAR INSTITUTE   (United States)

^c THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Calcium handling; Endoplasmic reticulum; Heart failure; Stress

Indexed keywords

CALRETICULIN; CELL NUCLEUS DNA; CYCLIC AMP DEPENDENT PROTEIN KINASE; INITIATION FACTOR 2ALPHA; METOPROLOL; PHOSPHOLAMBAN; RYANODINE RECEPTOR; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SODIUM CALCIUM EXCHANGE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL EMBOLISM; BETA ADRENERGIC RECEPTOR BLOCKING; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; CORONARY EMBOLIZATION; DNA DAMAGE; DNA FRAGMENTATION; ECHOCARDIOGRAPHY; ENDOPLASMIC RETICULUM STRESS; EXPERIMENTAL DOG; FEMALE; HEART FUNCTION; HEART HEMODYNAMICS; HEART MUSCLE ISCHEMIA; MALE; NONHUMAN; PRESSURE VOLUME CURVE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

ADMINISTRATION, ORAL; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CALCIUM; CALCIUM-BINDING PROTEINS; CALRETICULIN; DISEASE MODELS, ANIMAL; DOGS; EMBOLIZATION, THERAPEUTIC; ENDOPLASMIC RETICULUM; EUKARYOTIC INITIATION FACTOR-2; FEMALE; HEART FAILURE; HEMODYNAMICS; HOMEOSTASIS; IN SITU NICK-END LABELING; MALE; METOPROLOL; MYOCARDIUM; PHOSPHORYLATION; RECOVERY OF FUNCTION; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SODIUM-CALCIUM EXCHANGER; STRESS, PHYSIOLOGICAL; TIME FACTORS; VENTRICULAR FUNCTION, LEFT; VENTRICULAR PRESSURE;

EID: 79960787729     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvr106     Document Type: Article

References (48)

1. Wehrens XH, Marks AR. Novel therapeutic approaches for heart failure by normalizing calcium cycling. Nat Rev Drug Discov 2004;3:565-573. (Pubitemid 39022986)
2. Baumann O, Walz B. Endoplasmic reticulum of animal cells and its organization into structural and functional domains. Int Rev Cytol 2001;205:149-214. (Pubitemid 32390830)
3. Berridge MJ. The endoplasmic reticulum: a multifunctional signaling organelle. Cell Calcium 2002;32:235-249. (Pubitemid 36175747)
4. + and calcineurin-signaling from the endoplasmic reticulum. Cell 2004;17:383-389. (Pubitemid 39137095)
5. Rizzuto R, Pinton P, Ferrari D et al. Calcium and apoptosis: facts and hypotheses. Oncogene 2003;22:8619-8627. (Pubitemid 38019197)
6. Mattson MP, Chan SL. Calcium orchestrates apoptosis. Nat Cell Biol 2003;5: 1041-1043. (Pubitemid 37509106)
7. Rao RV, Ellerby HM, Bredesen DE. Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ 2004;11:372-380. (Pubitemid 38489415)
8. Sabbah HN, Sharov VG. Apoptosis in heart failure. Prog Cardiovasc Dis 1998;40: 549-562. (Pubitemid 28285177)
9. Sabbah HN, Sharov VG, Todor A, Singh V, Gupta RC, Goldstein S. Chronic therapy with metoprolol attenuates cardiomyocyte apoptosis in dogs with heart failure. J Am Coll Cardiol 2000;36:1698-1705.
10. He KL, Yi GH, Sherman W, Zhou H, Zhang GP, Gu A et al. Autologous skeletal myoblast transplantation improved hemodynamics and left ventricular function in chronic heart failure dogs. J Heart Lung Transplant 2005;24:1940-1949. (Pubitemid 41641872)
11. Knecht M, Burkhoff D, Yi GH, Popilskis S, Homma S, Packer M et al. Coronary endothelial dysfunction precedes heart failure and reduction of coronary reserve in awake dogs. Mol Cell Cardiol 1997;29:217-227. (Pubitemid 27129145)
12. He HL, Dickstein M, Sabbah HN, Yi GH, Gu A, Maurer M et al. Mechanisms of heart failure with well preserved ejection fraction in dogs following limited coronary microembolization. Cardiovasc Res 2004;64:72-83. (Pubitemid 39208924)
13. Lu L, Mei DF, Gu AG, Wang S, Lentzner B, Gutstein DE et al. Exercise training normalizes altered calcium-handling proteins during development of heart failure. J Appl Physiol 2002;92:1524-1530. (Pubitemid 34670908)
14. +- ATPase activity and expression in ventricular myocardium of dogs with heart failure. Am J Physiol 1997;273:H12-H18.
15. Reiken S, Gaburjakova M, Gaburjakova J, He KL, Preito A, Becker E et al. b-Adrenergic receptor blockers restore cardiac calcium release channel (ryanodine receptor) structure and function in heart failure. Circulation 2001;104:2843-2848. (Pubitemid 33126661)
16. Reiken S, Wehrens XH, Vest JA, Barnone A, Klotz S, Mancini D et al. Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure. Circulation 2003;107:2459-2466. (Pubitemid 36605229)
17. Goussev A, Sharov VG, Shimoyama H, Tanimura M, Lesch M, Goldstein S et al. Effects of ACE inhibition on cardiomyocyte apoptosis in dogs with heart failure. Am J Physiol 1998;275:H626-H631. (Pubitemid 128734433)
18. Sharov VG, Sabbah HN, Ali AS, Shimoyama H, Lesch M, Goldstein S. Abnormalities of cardiocytes in regions bordering fibrous scars in dogs with heart failure. Int J Cardiol 1997;60:273-279. (Pubitemid 27315424)
19. Arnaudeau S, Frieden M, Nakamura K, Castelbou C, Michalak M, Demaurex N. Calreticulin differentially modulates calcium uptake and release in the endoplasmic reticulum and mitochondria. J Biol Chem 2002;277:46696-46705. (Pubitemid 35417671)
20. Harding HP, Novoa I, Zhang Y, Zeng H,Wek R, Schapira M et al. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell 2000;6: 1099-1108.
21. Davies CH, Davia K, Bennett JG, Poole-Wilson PA, Harding SE. Reduced contraction and altered frequency response of isolated ventricular myocytes from patients with heart failure. Circulation 1995;92:2540-2549.
22. + transient in cardiomyocytes of dogs with chronic heart failure. Cell Mol Life Sci 1998;54:597-605. (Pubitemid 28325632)
23. Minamino T, Kitakaze M. ER stress in cardiovascular disease. J Mol Cell Cardiol 2010;48: 1105-1110.
24. Zhao L, Ackerman SL. Endoplasmic reticulum stress in health and disease. Curr Opin Biol 2006;18:444-452. (Pubitemid 44026518)
25. Kaufman RJ. Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev 1999;13: 1211-1233. (Pubitemid 29250189)
26. Packer M, Coats AJS, Fowler MB, Katus HA, Mohacsi P, Rouleau JL et al. Effect of carvedilol on survival in severe heart failure. New Engl J Med 2001;344:1651-1658. (Pubitemid 32479962)
27. +- and ATP-cycling imbalances in end-stage dilated and ischemic cardiomyopathies. Cardiovasc Res 1995;30:394-404.
28. + release from cardiac sarcoplasmic reticulum in tachycardia-induced heart failure. Cardiovasc Res 1999;44:146-155. (Pubitemid 29431692)
29. Hirsch JC, Borton AR, Albayya FP, Russell MW, Ohye RG, Metzger JM. Comparative analysis of parvalbumin and SERCA2a cardiac myocyte gene transfer in a large animal model of diastolic dysfunction. Am J Physiol Heart Circ Physiol 2004;286:H2314-H2321. (Pubitemid 38685248)
30. + signaling and calcium binding chaperones of the endoplasmic reticulum. Cell Calcium 2002;32:269-278. (Pubitemid 36175750)
31. Sambrook JF. The involvement of calcium in transport of secretory proteins from the endoplasmic reticulum. Cell 1990;61:197-199.
32. Haze K, Yoshida H, Yanagi H, Yura T, Mori K. Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol Biol Cell 1990;10:3787-3799.
33. Shi Y, Vattem KM, Sood R, An J, Linag J, Stramm L et al. Identification and characterization of pancreatic eukaryotic initiation factor 2 a-subunit kinase, PERK, involved in translational control. Mol Cell Biol 1998;18:7499-7509. (Pubitemid 28533068)
34. Harding HP, Zhang Y, Ron D. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 1999;397:271-274. (Pubitemid 29051178)
35. + ATPase 3 isoforms including the switch to ER stress, SERCA3f, in non-failing and failing human heart. Cell Calcium 2009;45:144-154.
36. Hussain SG, Ramaiah KVA. Endoplasmic reticulum: stress, signaling and apoptosis. Curr Sci 2007;93:1684-1696.
37. Xydas S, Kherani AR, Chang JS, Klotz S, Hay I, Mutrie CJ et al. beta(2)-Adrenergic stimulation attenuates left ventricular remodeling, decreases apoptosis, and improves calcium homeostasis in a rodent model of ischemic cardiomyopathy. J Pharmacol Exp Ther 2006;317:553-561.
38. Sabbah HN. Biologic rationale for the use of beta-blockers in the treatment of heart failure. Heart Failure Rev 2004;9:91-97. (Pubitemid 39485470)
39. Nakamura K, Bossy-Wetzel E, Burns K, Fadel MP, Lozyk M, Goping IS et al. Changes in endoplasmic reticulum luminal environment affect cell sensitivity to apoptosis. J Cell Biol 2000;150:731-740. (Pubitemid 30663411)
40. Scheuner D, Song B, McEwen E, Liu C, Laybutt R, Gillespie P et al. Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol Cell 2000;7:1165-1176.
41. Aparna G, Bhuyan AK, Sahdev S, Hasnain SE, Kaufman RJ, Ramaiah KV. Stress-induced apoptosis in Spodoptera frugiperda (Sf9) cells: baculovirus p35 mitigates eIF2 alpha phosphorylation. Biochemistry 2003;42:15352-15360. (Pubitemid 38031734)
42. Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D et al. A selective inhibitor of eIF2a dephosphorylation protects cells from ER stress. Science 2005; 307:935-939. (Pubitemid 40229232)
43. Harding HP, Zeng H, Zhang Y, Jungries R, Chung P, Plesken H et al. Diabetes mellitus and exocrine pancreatic dysfunction in perk/2 mice reveals a role for translational control in secretory cell survival. Mol Cell 2001;7:1153-1163. (Pubitemid 32607350)
44. Sabbah HN, Shimoyama H, Kono T, Gupta RC, Sharov VG, Scicli G et al. Effects of long-term monotherapy with enalapril, metoprolol, and digoxin on the progress of left ventricular dysfunction and dilatation in dogs with reduced ejection fraction. Circulation 1994;89:2852-2859. (Pubitemid 24173708)
45. Heilbrunn SM, Shah P, Bristow MR, Valantine HA, Ginsburg R, Fowler MB. Increased b-receptor density and improved hemodynamic response to catecholamine stimulation during long-term metoprolol therapy in heart failure from dilated cardiomyopathy. Circulation 1989;79:483-490. (Pubitemid 19087699)
46. Sun YL, Hu SJ, Wang LH, Hu Y, Zhou JY. Effect of beta-blockers on cardiac function and calcium handling protein in postinfarction heart failure rats. Chest 2005;128: 1812-1821. (Pubitemid 41324480)
47. Bristow MR. The adrenergic nervous system in heart failure. N Engl J Med 1984;311: 850-851. (Pubitemid 14035095)
48. Janczewski AM, Zahid M, Lemster BH, Frye CS, Gibson G, Higuchi Y et al. Phospholamban gene ablation improves calcium transients but not cardiac function in a heart failure model. Cardiovasc Res 2004;62:468-480. (Pubitemid 38648961)