Acute and sub-chronic toxicity studies of a standardized extract of Centella asiatica ECa 233

Thai Journal of Pharmaceutical Sciences

Volumn 35, Issue 2, 2011, Pages 55-64

  Chivapat, Songpol ^a   Chavalittumrong, Pranee ^a   Tantisira, Mayuree H ^b  

^a Ministry of Health   (Thailand)

^b CHULALONGKORN UNIVERSITY   (Thailand)

Author keywords

ECa 233; Standardized extract of centella asiatica; Toxicity

Indexed keywords

CENTELLA ASIATICA EXTRACT; SODIUM;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CHRONIC TOXICITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE INCREASE; FEMALE; FOOD INTAKE; HISTOPATHOLOGY; LEUKOCYTE COUNT; MALE; MOUSE; NONHUMAN; RAT; SUBCHRONIC TOXICITY; TOXICITY TESTING;

EID: 79960781542     PISSN: 01254685     EISSN: 19054637     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. R. H. Singh, K. Narsimhamurthy, and G. Singh. Neuronutrient impact of Ayurvedic rasayana therapy in brain aging, Biogerontology 9: 369-374 (2008).
2. B. Brinkhaus, M. Lindner, D. Schuppan, and E.G. Hahn. Chemical, pharmacological and clinical profile of the East Asian medical plant centella asiatica, Phytomedicine 7: 427-448 (2000).
3. R. Izu, A. Aguirre, N. Gil, and J. L. Diaz-Pirez. Allergic contact dermatitis from a cream containing Centella asiatica extract, Contact Dermatitis 26: 192-193 (1992).
4. S. Chivapat, P. Chavalittumrong, A. Attawish, T. Boonruad, J. Bansiddhi, S. Phadungpat, S. Punyamong, and J. Mingmuang. Toxicity study of Centella asiatica (L) urban, J. Thai Traditional and Alternative Medicine 2: 3-17 (2004).
5. M. Oruganti, B. Kumar Roy, K. Kumar Singh, R. Prasad, and S. Kumar. Safety assessment of Centella asiatica in albino rats, Phcog. J. 2: 5-11 (2010).
6. A. Kam-eg, B. Tantisira, and M. H. Tantisira. Preliminary study on effects of a standardized extract of Centella asiatica, ECa 233 on deficit of learning and memory by an intracerebroventricular injection of ß-amyloid peptide in mice, Thai J. Pharmacol. 31: 79-82 (2009).
7. K. Wannarat, M. H. Tantisira, and B. Tantisira. Wound healing effects of a standardized extract of Centalla asiatica ECa233 on burn wound in rats, Thai J. Pharmacol. 31: 120-123 (2009).
8. K. Kulthong, M.H. Tantisira, N. Niwattisaiwong, K. Apipalakul, S. Chevapat, and S. Lawanprasert. Effects of the standard extract of Centella asiatica (ECa233) on rat hepatic cytochrome P450, Thai J. Pharmacol. 33: 91-100 (2009).
9. M. G. Jayathirta, and S. H. Mishra. Preliminary immunomodulatory activities of methanol extracts of Eclipta alba and Centella asiatica, Phytomedicine 11: 361-365 (2004).
10. K. Punturee, C.P. Wild, W. Kasinrerk, and U. Vinitketkumnuen. Immunodulatory activities of Centella asiatica and Rhinacanthus nasutus extracts, Asian Pacific J. Cancer Prev. 6: 396-400 (2005).
11. Y. Pimainog, A. Yothinarak, and P. Jornrakate. Reference ranges for hematological and clinical chemistry values in Wistar rats, Bull. Dept. Med. Sci. 45: 27-36 (2003).
12. S.C. Gad. The rat: pathololgy. In: S.C. Gad, and C.P. Chengellis (eds.), Animal Models in Toxicology, Marcel Dekker, New York, 1982, pp.78-81.