Cardiac iron overload in transfusion-dependent patients with myelodysplastic syndromes

British Journal of Haematology

Volumn 154, Issue 4, 2011, Pages 521-524

  Roy, Noémi B A ^a   Myerson, Saul ^b   Schuh, Anna H ^b   Bignell, Patricia ^b   Patel, Roger ^c   Wainscoat, Jim S ^b   Mcgowan, Simon ^a   Marchi, Emanuele ^a   Atoyebi, Wale ^b   Littlewood, Tim ^b   Chacko, Joseph ^c   Vyas, Paresh ^a   Killick, Sally B ^c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b OXFORD UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^c ROYAL BOURNEMOUTH HOSPITAL   (United Kingdom)

Author keywords

Cardiac R2*; Hepatic R2*; Magnetic resonance imaging; Myelodysplastic syndromes; Transfusional iron overload

Indexed keywords

DEFERIPRONE; DEFEROXAMINE; FERRITIN;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; CHRONIC MYELOMONOCYTIC LEUKEMIA; CLINICAL ARTICLE; ERYTHROCYTE TRANSFUSION; FEMALE; HEART; HUMAN; IRON CHELATION; IRON OVERLOAD; LIVER; MALE; MYELODYSPLASTIC SYNDROME; MYELOPROLIFERATIVE DISORDER; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; REFRACTORY ANEMIA; REFRACTORY ANEMIA WITH EXCESS BLASTS; REFRACTORY CYTOPENIA WITH MULTILINEAGE DYSPLASIA; REFRACTORY CYTOPENIA WITH MULTILINEAGE DYSPLASIA AND RINGED SIDEROBLASTS;

AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; BLOOD TRANSFUSION; FEMALE; FERRITINS; HUMANS; IRON OVERLOAD; LIVER; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; MYOCARDIUM; RETROSPECTIVE STUDIES;

EID: 79960765638     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2011.08749.x     Document Type: Article

References (11)

1. Anderson, L.J., Holden, S., Davis, B., Prescott, E., Charrier, C.C., Bunce, N.H., Firmin, D.N., Wonke, B., Porter, J., Walker, J.M. & Pennell, D.J. (2001) Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. European Heart Journal, 22, 2171-2179.
2. Brechignac, S., Hellstrom-Lindberg, E., Bowen, D.T., DeWitte, T.M., Cazzola, M. & Fenaux, P. (2004) Quality of life and economic impact or red blood cell (RBC) transfusions on patients with myelodysplastic syndromes (MDS). Blood (ASH Annual Meeting Abstracts), 104, 263b. Abstract 4716.
3. Chacko, J., Pennell, D.J., Tanner, M.A., Hamblin, T.J., Wonke, B., Lecy, T., Thomas, P.W. & Killick, S.B. (2007) Myocardial iron loading by magnetic resonance imaging T2* in good prognosis myelodysplastic syndrome patients on long term transfusions. British Journal of Haematology, 138, 587-593.
4. Di Tucci, A.A., Matta, G., Deplano, S., Gabbas, A., Depau, C., Derudas, D., Caocci, G., Agus, A. & Angelucci, E. (2008) Myocardial iron overload assessment by T2* magnetic resonance imaging in adult transfusion dependent patients with acquired anemias. Hematologica, 93, 1385-1388.
5. Greenberg, P., Cox, C., LeBeau, M.M., Fenaux, P., Morel, P., Sanz, G., Sanz, M., Vallespi, T., Hamblin, T., Oscier, D., Ohyashiki, K., Toyama, K., Aul, C., Mufti, G. & Bennett, J. (1997) International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood, 89, 2079-2088.
6. Jensen, P.D., Jensen, F.T., Christensen, T., Eiskjaer, H., Baandrup, U. & Nielsen, J.L. (2003a) Evaluation of myocardial iron by magnetic resonance imaging during iron chelation therapy with deferrioxamine: indication of close relation between myocardial iron content and chelatable iron pool. Blood, 101, 4632-4639.
7. Jensen, P.D., Jensen, F.T., Christensen, T., Nielsen, J.L. & Ellegaard, J. (2003b) Relationship between hepatocellular injury and transfusional iron overload prior to and during chelation with desferrioxamine: a study in adult patients with acquired anaemias. Blood, 101, 91-96.
8. Konen, E., Ghoti, H., Winder, A., Kushnir, T., Eshet, Y. & Rachmilewitz, E. (2007) No evidence for myocardial iron overload in multitransfused patients with myelodysplastic syndrome using cardiac magnetic resonance T2* technique. American Journal of Hematology, 82, 1013-1016.
9. Lee, P. & Beutler, E. (2009) Regulation of hepcidin and iron overload disease. Annual Review of Pathology: Mechanisms of Disease, 4, 489-515.
10. Westwood, M.A., Anderson, L.J., Firmin, D.N., Gatehouse, P.D., Lorenz, C.H., Wonke, B. & Pennell, D.J. (2003) Interscanner reproducibility of cardiovascular magnetic resonance T2* measurements of tissue iron in thalassemia. Journal of Magnetic Resonance Imaging, 18, 616-620.
11. Wood, J.C., Enriquez, C., Ghurge, N., Tyzka, J.M., Carson, S., Nelson, M.D. & Coates, T.D. (2005) MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood, 106, 1460-1465.