Cadmium directly induced mitochondrial dysfunction of human embryonic kidney cells

Human and Experimental Toxicology

Volumn 30, Issue 8, 2011, Pages 920-929

  Mao, W P ^a   Zhang, N N ^a   Zhou, F Y ^a   Li, W X ^a   Liu, H Y ^a   Feng, J ^a   Zhou, L ^a   Wei, C J ^a   Pan, Y B ^a   He, Z J ^a  

^a NANJING NORMAL UNIVERSITY   (China)

Author keywords

cadmium; mitochondria; mitochondrial permeability; oxidative stress; reactive oxygen species

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CADMIUM CHLORIDE; GLUTATHIONE PEROXIDASE; LACTATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

APOPTOSIS; ARTICLE; CELL FUNCTION; CELL RESPIRATION; CELL STRAIN HEK293; CELL STRUCTURE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ELECTRON MICROSCOPY; EMBRYO; ENZYME INHIBITION; EXPOSURE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LIPID PEROXIDATION; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MITOCHONDRION SWELLING; OXIDATIVE STRESS; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATASES; APOPTOSIS; CADMIUM CHLORIDE; CELL CULTURE TECHNIQUES; ENVIRONMENTAL POLLUTANTS; HEK293 CELLS; HUMANS; LIPID PEROXIDATION; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MITOCHONDRIAL SWELLING; REACTIVE OXYGEN SPECIES;

EID: 79960749346     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327110384286     Document Type: Article

References (53)

1. Joseph P. Mechanisms of cadmium carcinogenesis. Toxicol Appl Pharmacol 2009 ; 238: 272-279.
2. Järup L., Berglund M., Elinder CG, Nordberg G., and Vahter M. Health effects of cadmium exposure: a review of the literature and a risk estimate. Scand J Work Environ Health 1998 ; 24: 1-51. (Pubitemid 28161916)
3. Thompson J., Bannigan J. Cadmium: toxic effects on the reproductive system and the embryo. Reprod Toxicol 2008 ; 25: 304-315.
4. Lee WK, Thévenod F. Novel roles for ceramides, calpains and caspases in kidney proximal tubule cell apoptosis: lessons from in vitro cadmium toxicity studies. Biochem Pharmacol 2008 ; 76: 1323-1332.
5. Tsangaris GT, Tzortzatou-Stathopoulou F. Cadmium induces apoptosis differentially on immune system cell lines. Toxicology 1998 ; 128: 143-150. (Pubitemid 28362970)
6. Fujimaki H., Ishido M., and Nohara K. Induction of apoptosis in mouse thymocytes by cadmium. Toxicol Lett 2000 ; 19: 99-105. (Pubitemid 30236266)
7. Kalariya NM, Wills NK, Ramana KV, Srivastava SK, and van Kuijk FJ Cadmium-induced apoptotic death of human retinal pigment epithelial cells is mediated by MAPK pathway. Exp Eye Res 2009 ; 89: 494-502.
8. Mao WP, Ye JL, Guan ZB, Zhao JM, Zhang C., Zhang NN, et al. Cadmium induces apoptosis in human embryonic kidney (HEK) 293 cells by caspase-dependent and -independent pathways acting on mitochondria. Toxicol In Vitro 2007 ; 21: 343-354. (Pubitemid 46453108)
9. Mignotte B., Vayssiere JL Mitochondria and apoptosis. Eur J Biochem 1998 ; 252: 1-15. (Pubitemid 28089952)
10. Huettenbrenner S., Maier S., Leisser C., Polgar D., Strasser S., Grusch M., et al. The evolution of cell death programs as prerequisites of multicellularity. Rev Mutat Res 2003 ; 543: 235-249. (Pubitemid 36645082)
11. Cannino G., Ferruggia E., Luparello C., and Rinaldi AM Cadmium and mitochondria. Mitochondrion 2009 ; 9: 377-384.
12. Green DR, Reed JC Mitochondria and apoptosis. Scienc 1998 ; 281: 1309-1312. (Pubitemid 28406816)
13. Murugavel P., Pari L., Sitasawad SL, Kumarb S., and Kumar S. Cadmium induced mitochondrial injury and apoptosis in vero cells: Protective effect of diallyl tetrasufide from garlic. Int J Biochem Cell Biol 2007 ; 39: 161-170. (Pubitemid 44548443)
14. Al-Nasser IA Cadmium hepatotoxicity and alterations of the mitochondrial function. J Toxicol Clin Toxicol 2000 ; 38: 407-413. (Pubitemid 30491104)
15. Rikans LE, Yamano T. Mechanisms of cadmium mediated acute hepatotoxicity. J Biochem Mol Toxicol 2000 ; 14: 110-117.
16. Ishido M., Homma ST, Leung PS, and Tohyama C. Cadmium induced DNA fragmentation is inhibitable by zinc in porcine kidney LLC-PK1 cells. Life Sci 1995 ; 56: 351-356.
17. Harstad EB, Klaassen CD Tumor necrosis factor-alpha-null mice are not resistant to cadmium chloride-induced hepatotoxicity. Toxicol Appl Pharmacol 2002 ; 179: 155-162. (Pubitemid 34275958)
18. Shih CM, Wu JS, Ko WC, Wang LF, Wei YH, Liang HF, et al. Mitochondria-mediated aspase-independent apoptosis induced by cadmium in normal human lung cells. J Cell Biochem 2003 ; 89: 335-347.
19. Lemarié A., Lagadic-Gossmann D., Morzadec C., Allain N., Fardel O., and Vernhet L. Cadmium induces caspase-independent apoptosis in liver Hep3B cells: role for calcium in signaling oxidative stress-related impairment of mitochondria and relocation of endonuclease G and apoptosis-inducing factor. Free Radic Biol Med 2004 ; 36: 1517-1531. (Pubitemid 38746560)
20. Pulido MP, Parrish AR Metal-induced apoptosis: mechanisms. Mutat Res 2003 ; 533: 227-241. (Pubitemid 37487871)
21. Pathak N., Khandelwal S. Oxidative stress and apoptotic changes in murine splenocytes exposed to cadmium. Toxicology 2006 ; 220: 26-36. (Pubitemid 43197626)
22. Zhou YJ, Zhang SP, Liu CW, and Cai YQ The protection of selenium on ROS mediated-apoptosis by mitochondria dysfunction in cadmium-induced LLC-PK(1) cells. Toxicol In Vitro 2009 ; 23: 288-294.
23. Stohs SJ, Bagchi D., Hassoun E., and Bagchi M. Oxidative mechanisms in the toxicity of chromium and cadmium ions. J Environ Pathol Toxicol Oncol 2001 ; 20: 77-88. (Pubitemid 32441336)
24. Waisberg M., Joseph P., Hale B., and Beyersmann D. Molecular and cellular mechanisms of cadmium carcinogenesis. Toxicology 2003 ; 192: 95-117. (Pubitemid 37311405)
25. Desagher S., Martinou JC Mitochondria as the central control point of apoptosis. Trends Cell Biol 2000 ; 10: 369-377. (Pubitemid 30612469)
26. Lee WK, Bork U., and The'venod F. Mitochondria as a target of cadmium nephrotoxicity: induction of swelling and cytochrome c release. Toxicol Mech Methods 2004 ; 14: 67-71. (Pubitemid 38166127)
27. Hunter DR, Haworth RA The Ca2+-induced membrane transition in mitochondria. I. The protective mechanisms. Arch Biochem Biophys 1979 ; 195: 453-459. (Pubitemid 9235077)
28. Emaus RK, Grunwald R., and Lemasters JJ Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties. Biochim Biophys Acta 1986 ; 850: 436-448. (Pubitemid 16077550)
29. Scaduto RC Jr, Grotyohann LW Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives. J Biophys 1999 ; 76: 469-477. (Pubitemid 29202474)
30. Bejma J., Ji LL Aging and acute exercise enhance free radical generation in rat skeletal muscle. J Appl Physiol 1999 ; 87: 465-470. (Pubitemid 29330715)
31. Oyanagui Y. Reevaluation of assay methods and establishment of kit for superoxide dismutase activity. Anal Biochem 1984 ; 142: 290-296. (Pubitemid 15177262)
32. Wang Y., Fang J., Leonard SS, and Rao KM Cadmium inhibits the electron transfer chain and induces reactive oxygen species. Free Radic Biol Med 2004 ; 36: 1434-1443. (Pubitemid 38596803)
33. Foster KA, Galeffi F., Gerich FJ, Turner DA, and Müller M. Optical and pharmacological tools to investigate the role of mitochondria during oxidative stress and neuro-degeneration. Prog Neurobiol 2006 ; 79: 136-171. (Pubitemid 44255860)
34. Feissner RF, Skalska J., Gaum WE, and Sheu SS Crosstalk signaling between mitochondrial Ca2+ and ROS. Front Biosci 2009 ; 14: 1197-11218.
35. Li M., Xia T., Jiang CS, Li LJ, Fu JL, and Zhou ZC Cadmium directly induced the opening of membrane permeability pore of mitochondria which possibly involved in cadmium-triggered apoptosis. Toxicology 2003 ; 194: 19-33. (Pubitemid 37421380)
36. Susin SA, Lorenzo HK, Zamzami N., Marzo I., Brenner C., Larochette N., et al. Mitochondrial release of caspase-2 and -9 during the apoptotic process. J Exp Med 1999 ; 189: 381-394.
37. Du C., Fang M., Li Y., Li L., and Wang X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 2000 ; 102: 33-43.
38. Oh SH, Choi JE, and Lima SC Protection of betulin against cadmium-induced apoptosis in hepatoma cells. Toxicology 2006 ; 220: 1-12.
39. Daugas E., Susin SA, Zamzami N., Ferri KF, Irinopoulou T., Larochette N., et al. Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis. FASEB J 2000 ; 14: 729-739. (Pubitemid 30198571)
40. Kim J., Soh J. Cadmium-induced apoptosis is mediated by the translocation of AIF to the nucleus in rat testes. Toxicol Lett 2009 ; 188: 45-51.
41. Lee WK, Bork U., Gholamrezaei F., and Thévenod F. Cd2+-induced cytochrome c release in apoptotic proximal tubule cells: role of mitochondrial permeability transition pore and Ca2+ uniporter. Am J Physiol Renal Physiol 2005 ; 288: F27 - F39.
42. Armstrong JS The role of the mitochondrial permeability transition in cell death. Mitochondrion 2006 ; 6: 225-234. (Pubitemid 44567384)
43. Erfurt C., Roussa E., and Thévenod F. Apoptosis by Cd2+ or CdMT in proximal tubule cells: different uptake routes and permissive role of endo/lysosomal CdMT uptake. Am J Physiol Cell Physiol 2003 ; 285: C1367 - C1376.
44. Li M., Kondo T., Zhao QL, Li FJ, Tanabe K., Arai Y., et al. Apoptosis induced by cadmium in human lymphoma U937 cells through Ca2+-calpain and caspase-mitochondria-dependent pathways. J Biol Chem 2000 ; 275: 39702-39709. (Pubitemid 32058998)
45. Aon MA, Cortassa S., Maack C., and O'Rourke B. Sequential opening of mitochondrial ion channels as a function of glutathione redox thiol status. J Biol Chem 2007 ; 282: 21889-21900. (Pubitemid 47195754)
46. López E., Arce C., Oset-Gasque MJ, Cañadas S., and González MP Cadmium induces reactive oxygen species generation and lipid peroxidation in cortical neurons in culture. Free Radical Biol Med 2006 ; 40: 940-951. (Pubitemid 43376003)
47. Fleury C., Mignotte B., and Vayssière JL Mitochondrial reactive oxygen species in cell death signaling. Biochimie 2002 ; 84: 131-141. (Pubitemid 34946949)
48. Higuchi Y. Glutathione depletion-induced chromosomal DNA fragmentation associated with apoptosis and necrosis. J Cell Mol Med 2004 ; 8: 455-464. (Pubitemid 44145478)
49. Fariss MW, Chan CB, Patel M., Van Houten B., and Orrenius S. Role of mitochondria in toxic oxidative stress. Mol Interv 2005 ; 5: 94-111. (Pubitemid 40590509)
50. Bognar Z., Kalai T., Palfi A., Hanto K., Bognar B., Mark L., et al. A novel SOD-mimetic permeability transition inhibitor agent protects ischemic heart by inhibiting both apoptotic and necrotic cell death. Free Radical Biol Med 2006 ; 41: 835-848. (Pubitemid 44163417)
51. Wu JH, Xu C., Shan CY, and Tan RX Antioxidant properties and PC12 cell protective effects of APS-1, a polysaccharide from Aloe vera var. chinensis. Life Sci 2006 ; 78: 622-630. (Pubitemid 41785769)
52. Devi SA, Kiran TR Regional responses in antioxidant system to exercise training and dietary Vitamin E in aging rat brain. Neurobiol Aging 2004 ; 25: 501-508. (Pubitemid 38317348)
53. Luqman S., Rizvi SI Protection of lipid peroxidation and carbonyl formation in proteins by capsaicin in human erythrocytes subjected to oxidative stress. Phytother Res 2006 ; 20: 303-306.