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Volumn 15, Issue 23, 2011, Pages 1-108

The RATPAC (randomised assessment of treatment using panel assay of cardiac markers) trial: A randomized controlled trial of point-of-care cardiac markers in the emergency department

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTACID AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BIOLOGICAL MARKER; CLOPIDOGREL; CREATINE KINASE MB; FIBRINOGEN RECEPTOR ANTAGONIST; GLYCERYL TRINITRATE; HEPARIN; MYOGLOBIN; TROPONIN I;

EID: 79960747981     PISSN: 13665278     EISSN: None     Source Type: Journal    
DOI: 10.3310/hta15230     Document Type: Article
Times cited : (48)

References (54)
  • 3
    • 36249003906 scopus 로고    scopus 로고
    • Universal definition of myocardial infarction
    • Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction
    • Thygesen K, Alpert JS, White HD; Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction. Universal definition of myocardial infarction. J Am Coll Cardiol 2007;50:2173-95.
    • (2007) J Am Coll Cardiol , vol.50 , pp. 2173-2195
    • Thygesen, K.1    Alpert, J.S.2    White, H.D.3
  • 4
    • 0033849392 scopus 로고    scopus 로고
    • A systematic review of troponin T and I values as a prognostic tool for patients with chest pain
    • Ebell MH, White LL, Weismantel D. A systematic review of troponin T and I values as a prognostic tool for patients with chest pain. J Fam Pract 2000;49:746-53.
    • (2000) J Fam Pract , vol.49 , pp. 746-753
    • Ebell, M.H.1    White, L.L.2    Weismantel, D.3
  • 5
    • 0036892858 scopus 로고    scopus 로고
    • Management of acute coronary syndromes in patients presenting without ST elevation
    • Task Force on the Management of Acute Coronary Syndromes of the European Society for Cardiology
    • Bertrand ME, Simoons ML, Fox KAA, Wallentin LC, Hamm CW, McFadden E, et al. Task Force on the Management of Acute Coronary Syndromes of the European Society for Cardiology. Management of acute coronary syndromes in patients presenting without ST elevation. Eur Heart J 2002;23:1809-40.
    • (2002) Eur Heart J , vol.23 , pp. 1809-1840
    • Bertrand, M.E.1    Simoons, M.L.2    Fox, K.A.A.3    Wallentin, L.C.4    Hamm, C.W.5    McFadden, E.6
  • 6
    • 0141496137 scopus 로고    scopus 로고
    • Cost effectiveness of diagnostic strategies for patients with acute, undifferentiated chest pain
    • Goodacre S, Calvert N. Cost effectiveness of diagnostic strategies for patients with acute, undifferentiated chest pain. Emerg Med J 2003;20:429-33.
    • (2003) Emerg Med J , vol.20 , pp. 429-433
    • Goodacre, S.1    Calvert, N.2
  • 8
    • 69349100568 scopus 로고    scopus 로고
    • Sensitive troponin I assay in early diagnosis of acute myocardial infarction
    • Keller T, Zeller T, Peetz D, Tziwas S, Roth A, Czyz E, et al. Sensitive troponin I assay in early diagnosis of acute myocardial infarction. N Engl J Med 2009;361:868-72.
    • (2009) N Engl J Med , vol.361 , pp. 868-872
    • Keller, T.1    Zeller, T.2    Peetz, D.3    Tziwas, S.4    Roth, A.5    Czyz, E.6
  • 9
    • 0034709724 scopus 로고    scopus 로고
    • Prospective audit of incidence of prognostically important myocardial damage in patients discharged from the emergency department
    • Collinson PO, Premachandram S, Hashemi K. Prospective audit of incidence of prognostically important myocardial damage in patients discharged from the emergency department. BMJ 2000;320:1702-5.
    • (2000) BMJ , vol.320 , pp. 1702-1705
    • Collinson, P.O.1    Premachandram, S.2    Hashemi, K.3
  • 10
    • 10744232654 scopus 로고    scopus 로고
    • Randomised controlled trial and economic evaluation of a chest pain observation unit compared with routine care
    • Goodacre S, Nicholl J, Dixon S, Cross E, Angelini K, Arnold J, et al. Randomised controlled trial and economic evaluation of a chest pain observation unit compared with routine care. BMJ 2004;328:254-7.
    • (2004) BMJ , vol.328 , pp. 254-257
    • Goodacre, S.1    Nicholl, J.2    Dixon, S.3    Cross, E.4    Angelini, K.5    Arnold, J.6
  • 11
    • 0037732728 scopus 로고    scopus 로고
    • National survey of emergency department management of patients with acute, undifferentiated chest pain
    • Goodacre S, Nicholl J, Beahan J, Quinney D, Capewell S. National survey of emergency department management of patients with acute, undifferentiated chest pain. Br J Cardiol 2003;10:50-4.
    • (2003) Br J Cardiol , vol.10 , pp. 50-54
    • Goodacre, S.1    Nicholl, J.2    Beahan, J.3    Quinney, D.4    Capewell, S.5
  • 12
    • 4644288539 scopus 로고    scopus 로고
    • A prospective randomised controlled trial of point-of-care testing on the coronary care unit
    • Collinson PO, John C, Lynch S, Rao A, Canepa-Anson R, Carson E, et al. A prospective randomised controlled trial of point-of-care testing on the coronary care unit. Ann Clin Biochem 2004;41:397-404.
    • (2004) Ann Clin Biochem , vol.41 , pp. 397-404
    • Collinson, P.O.1    John, C.2    Lynch, S.3    Rao, A.4    Canepa-Anson, R.5    Carson, E.6
  • 13
    • 48949120287 scopus 로고    scopus 로고
    • Impact of point-of-care testing in the emergency department evaluation and treatment of patients with suspected acute coronary syndromes
    • Renaud B, Maison P, Ngako A, Cunin P, Santin A, Hervé J, et al. Impact of point-of-care testing in the emergency department evaluation and treatment of patients with suspected acute coronary syndromes. Acad Emerg Med 2008;15:216-24.
    • (2008) Acad Emerg Med , vol.15 , pp. 216-224
    • Renaud, B.1    Maison, P.2    Ngako, A.3    Cunin, P.4    Santin, A.5    Hervé, J.6
  • 14
    • 60249086016 scopus 로고    scopus 로고
    • A multicenter randomized controlled trial comparing central laboratory and point-of-care cardiac marker testing strategies: The Disposition Impacted by Serial Point of Care Markers in Acute Coronary Syndromes (DISPO-ACS) trial
    • Ryan RJ, Lindsell CJ, Hollander JE, O'Neil B, Jackson R, Schreiber D, et al. A multicenter randomized controlled trial comparing central laboratory and point-of-care cardiac marker testing strategies: the Disposition Impacted by Serial Point of Care Markers in Acute Coronary Syndromes (DISPO-ACS) trial. Ann Emerg Med 2009;53:321-8.
    • (2009) Ann Emerg Med , vol.53 , pp. 321-328
    • Ryan, R.J.1    Lindsell, C.J.2    Hollander, J.E.3    O'Neil, B.4    Jackson, R.5    Schreiber, D.6
  • 15
    • 0032481814 scopus 로고    scopus 로고
    • Point of care testing: Randomised controlled trial of clinical outcomes
    • Kendall J, Reeves B, Clancy M. Point of care testing: randomised controlled trial of clinical outcomes. BMJ 1998;316:1052-7.
    • (1998) BMJ , vol.316 , pp. 1052-1057
    • Kendall, J.1    Reeves, B.2    Clancy, M.3
  • 16
    • 0033925967 scopus 로고    scopus 로고
    • A systematic review of troponin T and I for diagnosing acute myocardial infarction
    • Ebell MH, Flewelling D, Flynn CA. A systematic review of troponin T and I for diagnosing acute myocardial infarction. J Fam Pract 2000;49:550-6.
    • (2000) J Fam Pract , vol.49 , pp. 550-556
    • Ebell, M.H.1    Flewelling, D.2    Flynn, C.A.3
  • 17
    • 0035003889 scopus 로고    scopus 로고
    • Accuracy of cardiac biomarkers to diagnose acute cardiac ischaemia in the emergency department: A meta-analysis
    • Balk EM, Ioannidis JPA, Salem D, Chew PW, Lau J. Accuracy of cardiac biomarkers to diagnose acute cardiac ischaemia in the emergency department: a meta-analysis. Ann Emerg Med 2001;37:478-94.
    • (2001) Ann Emerg Med , vol.37 , pp. 478-494
    • Balk, E.M.1    Ioannidis, J.P.A.2    Salem, D.3    Chew, P.W.4    Lau, J.5
  • 18
    • 0031823526 scopus 로고    scopus 로고
    • Serial creatinine kinase (CK) MB testing during the emergency department evaluation of chest pain: Utility of a 2-hour deltaCK-MB of +1.6 ng/ml
    • Fesmire FM, Percy RF, Bardoner JB, Wharton DR, Calhoun FB. Serial creatinine kinase (CK) MB testing during the emergency department evaluation of chest pain: utility of a 2-hour deltaCK-MB of +1.6 ng/ml. Am Heart J 1998;136:237-44.
    • (1998) Am Heart J , vol.136 , pp. 237-244
    • Fesmire, F.M.1    Percy, R.F.2    Bardoner, J.B.3    Wharton, D.R.4    Calhoun, F.B.5
  • 19
    • 3042809549 scopus 로고    scopus 로고
    • Delta creatinine kinase MB outperforms myoglobin at two hours during the emergency department identification and exclusion of troponin positive non-ST elevation acute coronary syndromes
    • Fesmire FM, Christensen RH, Focy EP, Feintuch TA. Delta creatinine kinase MB outperforms myoglobin at two hours during the emergency department identification and exclusion of troponin positive non-ST elevation acute coronary syndromes. Ann Emerg Med 2004;44:12-19.
    • (2004) Ann Emerg Med , vol.44 , pp. 12-19
    • Fesmire, F.M.1    Christensen, R.H.2    Focy, E.P.3    Feintuch, T.A.4
  • 20
    • 0035949522 scopus 로고    scopus 로고
    • Ninetyminute exclusion of acute myocardial infarction by use of quantitative point-of-care testing of myoglobin and troponin I
    • McCord J, Nowak RM, McCullough PA, Foreback C, Borzak S, Tokarski G, et al. Ninetyminute exclusion of acute myocardial infarction by use of quantitative point-of-care testing of myoglobin and troponin I. Circulation 2001;104:1483-8.
    • (2001) Circulation , vol.104 , pp. 1483-1488
    • McCord, J.1    Nowak, R.M.2    McCullough, P.A.3    Foreback, C.4    Borzak, S.5    Tokarski, G.6
  • 21
    • 0032992634 scopus 로고    scopus 로고
    • Simultaneous rapid measurement of whole blood myoglobin, creatinine kinase MB and cardiac troponin I by the triage cardiac panel for detection of myocardial infarction
    • Apple FS, Christensen RH, Valdes R, Andriak Aj, Berg A, Duh SH, et al. Simultaneous rapid measurement of whole blood myoglobin, creatinine kinase MB and cardiac troponin I by the triage cardiac panel for detection of myocardial infarction. Clin Chem 1999;45:199-205.
    • (1999) Clin Chem , vol.45 , pp. 199-205
    • Apple, F.S.1    Christensen, R.H.2    Valdes, R.3    Aj, A.4    Berg, A.5    Duh, S.H.6
  • 22
    • 0035836612 scopus 로고    scopus 로고
    • Bedside multimarker testing for risk stratification in chest pain units: The CHECKMATE study
    • Newby LK, Storrow AB, Gibler WB, Garvey JL, Tucker JF, Kaplan AL, et al. Bedside multimarker testing for risk stratification in chest pain units: the CHECKMATE study. Circulation 2001;103:1832-7.
    • (2001) Circulation , vol.103 , pp. 1832-1837
    • Newby, L.K.1    Storrow, A.B.2    Gibler, W.B.3    Garvey, J.L.4    Tucker, J.F.5    Kaplan, A.L.6
  • 23
    • 0036142217 scopus 로고    scopus 로고
    • Evaluation of quantitative cardiac biomarker point of care testing in the emergency department
    • Caragher TE, Fernandez BB, Jacobs FL, Barr LA. Evaluation of quantitative cardiac biomarker point of care testing in the emergency department. J Emerg Med 2002;22:1-7.
    • (2002) J Emerg Med , vol.22 , pp. 1-7
    • Caragher, T.E.1    Fernandez, B.B.2    Jacobs, F.L.3    Barr, L.A.4
  • 25
    • 37849034544 scopus 로고    scopus 로고
    • Risk stratification of chest pain patients in the emergency department by a nurse utilizing a point of care protocol
    • Hamilton AJ, Swales LA, Neill J, Murphy JC, Darragh KM, Rocke LG, et al. Risk stratification of chest pain patients in the emergency department by a nurse utilizing a point of care protocol. Eur J Emerg Med 2008;15:9-15.
    • (2008) Eur J Emerg Med , vol.15 , pp. 9-15
    • Hamilton, A.J.1    Swales, L.A.2    Neill, J.3    Murphy, J.C.4    Darragh, K.M.5    Rocke, L.G.6
  • 26
    • 55649084786 scopus 로고    scopus 로고
    • Is it safe to discharge patients from accident and emergency using a rapid point of care triple cardiac marker test to rule out acute coronary syndrome in low to intermediate risk patients presenting with chest pain?
    • Rathore S, Knowles P, Mann APS, Dodds PA. Is it safe to discharge patients from accident and emergency using a rapid point of care triple cardiac marker test to rule out acute coronary syndrome in low to intermediate risk patients presenting with chest pain? Eur J Int Med 2008;19:537-40.
    • (2008) Eur J Int Med , vol.19 , pp. 537-540
    • Rathore, S.1    Knowles, P.2    Mann, A.P.S.3    Dodds, P.A.4
  • 27
    • 44849118236 scopus 로고    scopus 로고
    • A rapid point-of-care cardiac marker testing strategy facilitates the rapid diagnosis and management of chest pain patients in the emergency department
    • Straface AL, Myers JH, Kirchick HJ, Blick KE. A rapid point-of-care cardiac marker testing strategy facilitates the rapid diagnosis and management of chest pain patients in the emergency department. Am J Clin Pathol 2008;129:788-95.
    • (2008) Am J Clin Pathol , vol.129 , pp. 788-795
    • Straface, A.L.1    Myers, J.H.2    Kirchick, H.J.3    Blick, K.E.4
  • 28
    • 5344243126 scopus 로고    scopus 로고
    • Diagnostic value of serial measurement of cardiac markers in patients with chest pain: Limited value of adding myoglobin to troponin I for exclusion of myocardial infarction
    • Eggers KM, Oldgren J, Nordenskjold A, Lindahl B. Diagnostic value of serial measurement of cardiac markers in patients with chest pain: limited value of adding myoglobin to troponin I for exclusion of myocardial infarction. Am Heart J 2004;148:574-81.
    • (2004) Am Heart J , vol.148 , pp. 574-581
    • Eggers, K.M.1    Oldgren, J.2    Nordenskjold, A.3    Lindahl, B.4
  • 29
    • 0034675059 scopus 로고    scopus 로고
    • The TIMI risk score for unstable angina/non-ST elevation MI: A method for prognostication and therapeutic decision making
    • Antman EM, Cohen M, Berninck PJ, Horacek T, Papuchis G, Mautner B, et al. The TIMI risk score for unstable angina/non-ST elevation MI: a method for prognostication and therapeutic decision making. JAMA 2000;284:835-42.
    • (2000) JAMA , vol.284 , pp. 835-842
    • Antman, E.M.1    Cohen, M.2    Berninck, P.J.3    Horacek, T.4    Papuchis, G.5    Mautner, B.6
  • 32
  • 33
    • 0031753570 scopus 로고    scopus 로고
    • Analytical performance and clinical application of a new rapid bedside assay for the detection of serum cardiac troponin I
    • Heeschen C, Goldmann BU, Moeller RH, Hamm CW. Analytical performance and clinical application of a new rapid bedside assay for the detection of serum cardiac troponin I. Clin Chem 1998;44:1925-30.
    • (1998) Clin Chem , vol.44 , pp. 1925-1930
    • Heeschen, C.1    Goldmann, B.U.2    Moeller, R.H.3    Hamm, C.W.4
  • 34
    • 0032830161 scopus 로고    scopus 로고
    • Evaluation of a rapid whole blood ELISA for quantification of troponin I in patients with acute chest pain
    • Heeschen C, Goldmann BU, Langenbrink L, Matschuck G, Hamm CW. Evaluation of a rapid whole blood ELISA for quantification of troponin I in patients with acute chest pain. Clin Chem 1999;45:1789-96.
    • (1999) Clin Chem , vol.45 , pp. 1789-1796
    • Heeschen, C.1    Goldmann, B.U.2    Langenbrink, L.3    Matschuck, G.4    Hamm, C.W.5
  • 36
    • 35148818363 scopus 로고    scopus 로고
    • The ESCAPE cluster randomised trial: Effectiveness and safety of chest pain assessment to prevent emergency admissions
    • On behalf of the ESCAPE Research Team
    • Goodacre S, Cross E, Lewis C, Nicholl J, Capewell S, On behalf of the ESCAPE Research Team. The ESCAPE cluster randomised trial: effectiveness and safety of chest pain assessment to prevent emergency admissions. BMJ 2007;335:659-62.
    • (2007) BMJ , vol.335 , pp. 659-662
    • Goodacre, S.1    Cross, E.2    Lewis, C.3    Nicholl, J.4    Capewell, S.5
  • 37
    • 0034789975 scopus 로고    scopus 로고
    • Psychological morbidity and health-related quality of life of patients assessed on a chest pain observation unit
    • Goodacre S, Mason S, Arnold J, Angelini K. Psychological morbidity and health-related quality of life of patients assessed on a chest pain observation unit. Ann Emerg Med 2001;38:369-76.
    • (2001) Ann Emerg Med , vol.38 , pp. 369-376
    • Goodacre, S.1    Mason, S.2    Arnold, J.3    Angelini, K.4
  • 38
    • 33748056810 scopus 로고    scopus 로고
    • The TIMI risk score accurately risk stratifies patients with undifferentiated chest pain presenting to an emergency department
    • Conway Morris A, Caesar D, Gray S, Gray A. The TIMI risk score accurately risk stratifies patients with undifferentiated chest pain presenting to an emergency department. Heart 2006;92:1333-4.
    • (2006) Heart , vol.92 , pp. 1333-1334
    • Conway Morris, A.1    Caesar, D.2    Gray, S.3    Gray, A.4
  • 40
    • 27744468588 scopus 로고    scopus 로고
    • Good research practices for cost-effectiveness analysis alongside clinical trials: The ISPOR RCT-CEA Task Force Report
    • Ramsey S, Willke R, Briggs A, Brown R, Buxton M, Chawla A, et al. Good research practices for cost-effectiveness analysis alongside clinical trials: The ISPOR RCT-CEA Task Force Report. Value Health 2001;8:521-33.
    • (2001) Value Health , vol.8 , pp. 521-533
    • Ramsey, S.1    Willke, R.2    Briggs, A.3    Brown, R.4    Buxton, M.5    Chawla, A.6
  • 41
    • 4544286541 scopus 로고    scopus 로고
    • National Institute for Clinical Excellence (NICE), London: NICE
    • National Institute for Clinical Excellence (NICE). Guide to the methods of technology appraisal. London: NICE; 2004.
    • (2004) Guide to The Methods of Technology Appraisal
  • 42
    • 0003462471 scopus 로고    scopus 로고
    • Canterbury: University of Kent, Personal Social Services Research Unit
    • Netten A, Curtis L. Unit costs of health and social care 2004. Canterbury: University of Kent, Personal Social Services Research Unit; 2004.
    • (2004) Unit Costs of Health and Social Care , vol.2004
    • Netten, A.1    Curtis, L.2
  • 43
    • 34547201716 scopus 로고    scopus 로고
    • Department of Health (DoH)
    • Department of Health (DoH). NHS reference costs 2005. URL: www.dh.gov.uk/PolicyAndGuidance/OrganisationPolicy/FinanceAndPlanning/NHSReferenceCosts/fs/en
    • NHS Reference Costs 2005
  • 44
    • 0035669803 scopus 로고    scopus 로고
    • Representing uncertainty: The role of cost effectiveness acceptability curves
    • Fenwick E, Claxton K, Sculpher M. Representing uncertainty: the role of cost effectiveness acceptability curves. Health Econ Lett 2001;10:779-87.
    • (2001) Health Econ Lett , vol.10 , pp. 779-787
    • Fenwick, E.1    Claxton, K.2    Sculpher, M.3
  • 47
    • 14344256680 scopus 로고    scopus 로고
    • Probabilistic analysis of cost-effectiveness models: Statistical representation of parameter uncertainty
    • Briggs A. Probabilistic analysis of cost-effectiveness models: statistical representation of parameter uncertainty. Value Health 2005;8:1-2.
    • (2005) Value Health , vol.8 , pp. 1-2
    • Briggs, A.1
  • 48
    • 50849114487 scopus 로고    scopus 로고
    • Costeffectiveness of chest pain unit care in the NHS
    • on behalf of the ESCAPE Research Team
    • Oluboyede Y, Goodacre S, Wailoo AJ on behalf of the ESCAPE Research Team. Costeffectiveness of chest pain unit care in the NHS. BMC Health Serv Res 2008;8:174.
    • (2008) BMC Health Serv Res , vol.8 , pp. 174
    • Oluboyede, Y.1    Goodacre, S.2    Wailoo, A.J.3
  • 50
    • 10444284584 scopus 로고    scopus 로고
    • British Medical Association and Royal Pharmaceutical Society of Great Britain, No. 58, March 2008, London: BMA and RPS
    • British Medical Association and Royal Pharmaceutical Society of Great Britain. British national formulary. No. 58, March 2008. London: BMA and RPS; 2008.
    • (2008) British National Formulary
  • 51
    • 0035682855 scopus 로고    scopus 로고
    • Is a chest pain observation unit likely to be cost saving in a British hospital?
    • Goodacre S, Morris F, Arnold J, Angelini K. Is a chest pain observation unit likely to be cost saving in a British hospital? Emerg Med J 2001;18:11-14.
    • (2001) Emerg Med J , vol.18 , pp. 11-14
    • Goodacre, S.1    Morris, F.2    Arnold, J.3    Angelini, K.4
  • 53
    • 20344396400 scopus 로고    scopus 로고
    • Is a chest pain observation unit likely to be cost effective at my hospital? Extrapolation of data from a randomised controlled trial
    • Goodacre S, Dixon S. Is a chest pain observation unit likely to be cost effective at my hospital? Extrapolation of data from a randomised controlled trial. Emerg Med J 2005;22:418-22.
    • (2005) Emerg Med J , vol.22 , pp. 418-422
    • Goodacre, S.1    Dixon, S.2
  • 54
    • 71749119251 scopus 로고    scopus 로고
    • Department of Health
    • Department of Health. NHS reference costs 2007-8.URL: www.dh.gov.uk/prod_consum_dh/groups/dh_digitalassets/documents/digitalasset/dh_098949.xls
    • NHS Reference Costs 2007-8


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