PWD/PhJ and WSB/EiJ mice are resistant to diet-induced obesity but have abnormal insulin secretion

Endocrinology

Volumn 152, Issue 8, 2011, Pages 3005-3017

  Lee, Katie T Y ^a   Karunakaran, Subashini ^a   Ho, Maggie M ^a   Clee, Susanne M ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; GLUCOSE; INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY FAT; CALORIC INTAKE; CONTROLLED STUDY; DIABETES MELLITUS; DIET RESTRICTION; DISEASE RESISTANCE; ENERGY EXPENDITURE; FOOD INTAKE; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; LIPID DIET; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; OBESITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PWD MOUSE; WILD TYPE; WSB MOUSE;

ADIPONECTIN; ANIMALS; BLOOD GLUCOSE; DIETARY FATS; INSULIN; INSULIN RESISTANCE; MICE; MICE, INBRED STRAINS; OBESITY;

EID: 79960744397     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2011-0060     Document Type: Article

References (89)

1. Finkelstein EA, Trogdon JG, Brown DS, Allaire BT, Dellea PS, Kamal-Bahl SJ 2008 The lifetime medical cost burden of overweight and obesity: implications for obesity prevention. Obesity 16:1843-1848
2. Ostbye T, Dement JM, Krause KM 2007 Obesity and workers' compensation: results from the Duke Health and Safety Surveillance System. Arch Intern Med 167:766-773 (Pubitemid 46658333)
3. Després JP, Lemieux I, Bergeron J, Pibarot P, Mathieu P, Larose E, Rodés-Cabau J, Bertrand OF, Poirier P 2008 Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk. Arterioscler Thromb Vasc Biol 28:1039-1049
4. Eckel RH, Krauss RM 1998 American Heart Association call to action: obesity as a major risk factor for coronary heart disease. AHA Nutrition Committee. Circulation 97:2099-2100 (Pubitemid 28262114)
5. Hubert HB, Feinleib M, McNamara PM, Castelli WP 1983 Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study. Circulation 67:968-977 (Pubitemid 13080473)
6. Ariza MA, Vimalananda VG, Rosenzweig JL 2010 The economic consequences of diabetes and cardiovascular disease in the United States. Rev Endocr Metab Disord 11:1-10
7. Sladek R, Rocheleau G, Rung J, Dina C, Shen L, Serre D, Boutin P, Vincent D, Belisle A, Hadjadj S, Balkau B, Heude B, Charpentier G, Hudson TJ, Montpetit A, Pshezhetsky AV, Prentki M, Posner BI, Balding DJ, Meyre D, Polychronakos C, Froguel P 2007 A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445:881-885
8. Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, Erdos MR, Stringham HM, Chines PS, Jackson AU, Prokunina-Olsson L, Ding CJ, Swift AJ, Narisu N, Hu T, Pruim R, Xiao R, Li XY, Conneely KN, Riebow NL, Sprau AG, Tong M, White PP, Hetrick KN, Barnhart MW, Bark CW, Goldstein JL, Watkins L, Xiang F, Saramies J, Buchanan TA, Watanabe RM, Valle TT, Kinnunen L, Abecasis GR, Pugh EW, Doheny KF, Bergman RN, Tuomilehto J, Collins FS, Boehnke M 2007 A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316:1341-1345 (Pubitemid 46871655)
9. Wellcome Trust Case Control Consortium 2007 Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447:661-678
10. Scuteri A, Sanna S, Chen WM, Uda M, Albai G, Strait J, Najjar S, Nagaraja R, Orrú M, Usala G, Dei M, Lai S, Maschio A, Busonero F, Mulas A, Ehret GB, Fink AA, Weder AB, Cooper RS, Galan P, Chakravarti A, Schlessinger D, Cao A, Lakatta E, Abecasis GR 2007 Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 3:e115
11. Saxena R, Hivert MF, Langenberg C, Tanaka T, Pankow JS, Vollenweider P, Lyssenko V, Bouatia-Naji N, Dupuis J, Jackson AU, Kao WH, Li M, Glazer NL, Manning AK, Luan J, Stringham HM, Prokopenko I, Johnson T, Grarup N, Boesgaard TW, Lecoeur C, Shrader P, O'Connell J, Ingelsson E, Couper DJ, et al. 2010 Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet 42:142-148
12. Sabatti C, Service SK, Hartikainen AL, Pouta A, Ripatti S, Brodsky J, Jones CG, Zaitlen NA, Varilo T, Kaakinen M, Sovio U, Ruokonen A, Laitinen J, Jakkula E, Coin L, Hoggart C, Collins A, Turunen H, Gabriel S, Elliot P, McCarthy MI, Daly MJ, Järvelin MR, Freimer NB, Peltonen L 2009 Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet 41:35-46
13. Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, Thorleifsson G, Loos RJ, Manning AK, Jackson AU, Aulchenko Y, Potter SC, Erdos MR, Sanna S, Hottenga JJ, Wheeler E, Kaakinen M, Lyssenko V, Chen WM, Ahmadi K, Beckmann JS, Bergman RN, Bochud M, Bonnycastle LL, Buchanan TA, Cao A, et al. 2009 Variants in MTNR1B influence fasting glucose levels. Nat Genet 41: 77-81
14. Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Allen HL, Lindgren CM, Luan J, Mägi R, Randall JC, Vedantam S, Winkler TW, Qi L, Workalemahu T, Heid IM, Steinthorsdottir V, Stringham HM, Weedon MN, Wheeler E, Wood AR, Ferreira T, Weyant RJ, Segrè AV, Estrada K, et al. 2010 Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 42:937-948
15. Bell CG, Walley AJ, Froguel P 2005 The genetics of human obesity. Nat Rev Genet 6:221-234 (Pubitemid 40293032)
16. Das SK, Elbein SC 2006 The Genetic Basis of Type 2 Diabetes. Cellscience 2:100-131
17. Clee SM, Attie A 2007 The genetic landscape of type 2 diabetes in mice. Endocr Rev 28:48-83 (Pubitemid 46220850)
18. Hull RL, Kodama K, Utzschneider KM, Carr DB, Prigeon RL, Kahn SE 2005 Dietary-fat-induced obesity in mice results in β-cell hyperplasia but not increased insulin release: evidence for specificity of impaired β-cell adaptation. Diabetologia 48:1350-1358 (Pubitemid 41186101)
19. Bock T, Pakkenberg B, Buschard K 2005 Genetic background determines the size and structure of the endocrine pancreas. Diabetes 54:133-137 (Pubitemid 40105104)
20. Veroni MC, Proietto J, Larkins RG 1991 Evolution of insulin resistance in New Zealand obese mice. Diabetes 40:1480-1487
21. Aston-Mourney K, Wong N, Kebede M, Zraika S, Balmer L, Mc-Mahon JM, Fam BC, Favaloro J, Proietto J, Morahan G, Andrikopoulos S 2007 Increased nicotinamide nucleotide transhydrogenase levels predispose to insulin hypersecretion in a mouse strain susceptible to diabetes. Diabetologia 50:2476-2485 (Pubitemid 350060635)
22. Mott R 2007 A haplotype map for the laboratory mouse. Nat Genet 39:1054-1056 (Pubitemid 47340638)
23. Yang H, Bell TA, Churchill GA, Pardo-Manuel de Villena F 2007 On the subspecific origin of the laboratory mouse. Nat Genet 39: 1100-1107 (Pubitemid 47340646)
24. Frazer KA, Eskin E, Kang HM, Bogue MA, Hinds DA, Beilharz EJ, Gupta RV, Montgomery J, Morenzoni MM, Nilsen GB, Pethiyagoda CL, Stuve LL, Johnson FM, Daly MJ, Wade CM, Cox DR 2007 A sequence-based variation map of 8.27 million SNPs in inbred mouse strains. Nature 448:1050-1053 (Pubitemid 47345584)
25. Wade CM, Kulbokas 3rd EJ, Kirby AW, Zody MC, Mullikin JC, Lander ES, Lindblad-Toh K, Daly MJ 2002 The mosaic structure of variation in the laboratory mouse genome. Nature 420:574-578 (Pubitemid 35477050)
26. Wade CM, Daly MJ 2005 Genetic variation in laboratory mice. Nat Genet 37:1175-1180 (Pubitemid 41568696)
27. Gregorová S, Forejt J 2000 PWD/Ph and PWK/Ph inbred mouse strains of Mus m. musculus subspecies: a valuable resource of phenotypic variations and genomic polymorphisms. Folia Biol (Praha) 46:31-41 (Pubitemid 30079599)
28. Svenson KL, Von Smith R, Magnani PA, Suetin HR, Paigen B, Naggert JK, Li R, Churchill GA, Peters LL 2007 Multiple trait measurements in 43 inbred mouse strains capture the phenotypic diversity characteristic of human populations. J Appl Physiol 102:2369-2378 (Pubitemid 47080772)
29. Reed DR, Bachmanov AA, Tordoff MG 2007 Forty mouse strain survey of body composition. Physiol Behav 91:593-600 (Pubitemid 47260612)
30. Naggert J, Svenson K, Smith R, Paigen B, Peters L 2003 Diet effects on bone mineral density and content, body composition, and plasma glucose, leptin, and insulin levels in 43 inbred strains of mice on a high-fat atherogenic diet. MPD:Naggert1. Mouse Phenome Database, The Jackson Laboratory, Bar Harbor, ME. http://www.jax.org/phenome. Accessed December 13, 2010
31. Weir JB 1949 New methods for calculating metabolic rate with special reference to protein metabolism. J Physiol 109:1-9
32. Butler AA, Kozak LP 2010 A recurring problem with the analysis of energy expenditure in genetic models expressing lean and obese phenotypes. Diabetes 59:323-329
33. Ellacott KL, Morton GJ, Woods SC, Tso P, Schwartz MW 2010 Assessment of feeding behavior in laboratory mice. Cell Metab 12: 10-17
34. Kaiyala KJ, Morton GJ, Leroux BG, Ogimoto K, Wisse B, Schwartz MW2010 Identification of body fat mass as a major determinant of metabolic rate in mice. Diabetes 59:1657-1666
35. Surwit RS, Feinglos MN, Rodin J, Sutherland A, Petro AE, Opara EC, Kuhn CM, Rebuffé-Scrive M 1995 Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice. Metabolism 44:645-651
36. Kashyap SR, Defronzo RA 2007 The insulin resistance syndrome: physiological considerations. Diab Vasc Dis Res 4:13-19 (Pubitemid 46649069)
37. Saad MF, Knowler WC, Pettitt DJ, Nelson RG, Mott DM, Bennett PH 1989 Sequential changes in serum insulin concentration during development of non-insulin-dependent diabetes. Lancet 1:1356-1359 (Pubitemid 19151955)
38. Gulli G, Ferrannini E, Stern M, Haffner S, DeFronzo RA 1992 The metabolic profile of NIDDM is fully established in glucose-tolerant offspring of two Mexican-American NIDDM parents. Diabetes 41: 1575-1586
39. Kahn SE, Prigeon RL, McCulloch DK, Boyko EJ, Bergman RN, Schwartz MW, Neifing JL, Ward WK, Beard JC, Palmer JP 1993 Quantification of the relationship between insulin sensitivity and β-cell function in human subjects. Evidence for a hyperbolic function. Diabetes 42:1663-1672 (Pubitemid 23318125)
40. Bergman RN, Phillips LS, Cobelli C 1981 Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and β-cell glucose sensitivity from the response to intravenous glucose. J Clin Invest 68:1456-1467 (Pubitemid 12194400)
41. Surwit RS, Kuhn CM, Cochrane C, McCubbin JA, Feinglos MN 1988 Diet-induced type II diabetes in C57BL/6J mice. Diabetes 37: 1163-1167 (Pubitemid 19035045)
42. Toye AA, Lippiat JD, Proks P, Shimomura K, Bentley L, Hugill A, Mijat V, Goldsworthy M, Moir L, Haynes A, Quarterman J, Freeman HC, Ashcroft FM, Cox RD 2005 A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice. Diabetologia 48:675-686 (Pubitemid 40591223)
43. Andrikopoulos S, Massa CM, Aston-Mourney K, Funkat A, Fam BC, Hull RL, Kahn SE, Proietto J 2005 Differential effect of inbred mouse strain (C57BL/6, DBA/2, 129T2) on insulin secretory function in response to a high fat diet. J Endocrinol 187:45-53 (Pubitemid 41556400)
44. Kooptiwut S, Zraika S, Thorburn AW, Dunlop ME, Darwiche R, Kay TW, Proietto J, Andrikopoulos S 2002 Comparison of insulin secretory function in two mouse models with different susceptibility to β-cell failure. Endocrinology 143:2085-2092 (Pubitemid 34521556)
45. Ahrén B, Pacini G 2002 Insufficient islet compensation to insulin resistance vs. reduced glucose effectiveness in glucose-intolerant mice. Am J Physiol Endocrinol Metab 283:E738-E744
46. Bruttomesso D, Pianta A, Mari A, Valerio A, Marescotti MC, Avogaro A, Tiengo A, Del Prato S 1999 Restoration of early rise in plasma insulin levels improves the glucose tolerance of type 2 diabetic patients. Diabetes 48:99-105 (Pubitemid 29019358)
47. Del Prato S, Marchetti P, Bonadonna RC 2002 Phasic insulin release and metabolic regulation in type 2 diabetes. Diabetes 51(Suppl 1): S109-S116 (Pubitemid 34761504)
48. Del Prato S 2003 Loss of early insulin secretion leads to postprandial hyperglycaemia. Diabetologia 46(Suppl 1):M2-M8 (Pubitemid 36543097)
49. Kahn SE, Montgomery B, Howell W, Ligueros-Saylan M, Hsu CH, Devineni D, McLeod JF, Horowitz A, Foley JE 2001 Importance of early phase insulin secretion to intravenous glucose tolerance in subjects with type 2 diabetes mellitus. J Clin Endocrinol Metab 86: 5824-5829 (Pubitemid 33152630)
50. Berg AH, Combs TP, Du X, Brownlee M, Scherer PE 2001 The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 7:947-953
51. Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, Mori Y, Ide T, Murakami K, Tsuboyama-Kasaoka N, Ezaki O, Akanuma Y, Gavrilova O, Vinson C, Reitman ML, Kagechika H, Shudo K, Yoda M, Nakano Y, Tobe K, Nagai R, Kimura S, Tomita M, Froguel P, Kadowaki T 2001 The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7:941-946 (Pubitemid 32756432)
52. Pajvani UB, Hawkins M, Combs TP, Rajala MW, Doebber T, Berger JP, Wagner JA, Wu M, Knopps A, Xiang AH, Utzschneider KM, Kahn SE, Olefsky JM, Buchanan TA, Scherer PE 2004 Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J Biol Chem 279:12152-12162 (Pubitemid 38445780)
53. Black BL, Croom J, Eisen EJ, Petro AE, Edwards CL, Surwit RS 1998 Differential effects of fat and sucrose on body composition in A/J and C57BL/6 mice. Metabolism 47:1354-1359 (Pubitemid 28523467)
54. Ahrén B, Scheurink AJ 1998 Marked hyperleptinemia after high-fat diet associated with severe glucose intolerance in mice. Eur J Endocrinol 139:461-467 (Pubitemid 28494094)
55. Ahrén B, Simonsson E, Scheurink AJ, Mulder H, Myrsén U, Sundler F 1997 Dissociated insulinotropic sensitivity to glucose and carbachol in high-fat diet-induced insulin resistance in C57BL/6J mice. Metabolism 46:97-106 (Pubitemid 27052032)
56. Burcelin R, Crivelli V, Dacosta A, Roy-Tirelli A, Thorens B 2002 Heterogeneous metabolic adaptation of C57BL/6J mice to high-fat diet. Am J Physiol Endocrinol Metab 282:E834-E842 (Pubitemid 34654745)
57. Blüher M, Kahn BB, Kahn CR 2003 Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299:572-574 (Pubitemid 36135156)
58. Shanik MH, Xu Y, Skrha J, Dankner R, Zick Y, Roth J 2008 Insulin resistance and hyperinsulinemia: is hyperinsulinemia the cart or the horse? Diabetes Care 31(Suppl 2):S262-S268
59. Patti ME, Kahn CR 1996 Lessons from transgenic and knockout animals about noninsulin-dependent diabetes mellitus. Trends Endocrinol Metab 7:311-319 (Pubitemid 26391526)
60. Gray SL, Donald C, Jetha A, Covey SD, Kieffer TJ 2010 Hyperin-sulinemia precedes insulin resistance in mice lacking pancreatic β-cell leptin signaling. Endocrinology 151:4178-4186
61. Nolan CJ, Madiraju MS, Delghingaro-Augusto V, Peyot ML, Prentki M 2006 Fatty acid signaling in the β-cell and insulin secretion. Diabetes 55(Suppl 2):S16-S23 (Pubitemid 44927028)
62. Amiel SA, Caprio S, Sherwin RS, Plewe G, Haymond MW, Tamborlane WV 1991 Insulin resistance of puberty: a defect restricted to peripheral glucose metabolism. J Clin Endocrinol Metab 72:277-282 (Pubitemid 21921688)
63. Moran A, Jacobs Jr DR, Steinberger J, Hong CP, Prineas R, Luepker R, Sinaiko AR 1999 Insulin resistance during puberty: results from clamp studies in 357 children. Diabetes 48:2039-2044 (Pubitemid 29458369)
64. Vilsbøll T, Holst JJ 2004 Incretins, insulin secretion and Type 2 diabetes mellitus. Diabetologia 47:357-366 (Pubitemid 38491230)
65. Efendic S, Portwood N 2004 Overview of incretin hormones. Horm Metab Res 36:742-746 (Pubitemid 40115893)
66. Perley MJ, Kipnis DM 1967 Plasma insulin responses to oral and intravenous glucose: studies in normal and diabetic subjects. J Clin Invest 46:1954-1962
67. Baggio LL, Drucker DJ 2007 Biology of incretins: GLP-1 and GIP. Gastroenterology 132:2131-2157 (Pubitemid 46711096)
68. Yu X, Park BH, Wang MY, Wang ZV, Unger RH 2008 Making insulin-deficient type 1 diabetic rodents thrive without insulin. Proc Natl Acad Sci USA 105:14070-14075
69. Frühbeck G, Salvador J 2000 Relation between leptin and the regulation of glucose metabolism. Diabetologia 43:3-12 (Pubitemid 30129297)
70. Wang MY, Chen L, Clark GO, Lee Y, Stevens RD, Ilkayeva OR, Wenner BR, Bain JR, Charron MJ, Newgard CB, Unger RH 2010 Leptin therapy in insulin-deficient type I diabetes. Proc Natl Acad Sci USA 107:4813-4819
71. + channels in pancreatic β-cells. Diabetes 46:1087-1093
72. Hu E, Liang P, Spiegelman BM 1996 AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 271:10697-10703 (Pubitemid 26145805)
73. Milan G, Granzotto M, Scarda A, Calcagno A, Pagano C, Federspil G, Vettor R 2002 Resistin and adiponectin expression in visceral fat of obese rats: effect of weight loss. Obes Res 10:1095-1103 (Pubitemid 135686650)
74. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K, Kuriyama H, Nishida M, Yamashita S, Okubo K, Matsubara K, Muraguchi M, Ohmoto Y, Funahashi T, Matsuzawa Y 1999 Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 257:79-83 (Pubitemid 29299050)
75. Kamari Y, Grossman E, Oron-Herman M, Peleg E, Shabtay Z, Shamiss A, Sharabi Y 2007 Metabolic stress with a high carbohydrate diet increases adiponectin levels. Horm Metab Res 39:384-388 (Pubitemid 46877856)
76. Li J, Yu X, Pan W, Unger RH 2002 Gene expression profile of rat adipose tissue at the onset of high-fat-diet obesity. Am J Physiol Endocrinol Metab 282:E1334-E1341 (Pubitemid 34654703)
77. Marecki JC, Ronis MJ, Shankar K, Badger TM 2011 Hyperinsulinemia and ectopic fat deposition can develop in the face of hyperadiponectinemia in young obese rats. J Nutr Biochem 22:142-152
78. Motoshima H, Wu X, Sinha MK, Hardy VE, Rosato EL, Barbot DJ, Rosato FE, Goldstein BJ 2002 Differential regulation of adiponectin secretion from cultured human omental and subcutaneous adipocytes: effects of insulin and rosiglitazone. J Clin Endocrinol Metab 87:5662-5667 (Pubitemid 36034375)
79. Pérez-Echarri N, Pérez-Matute P, Martínez JA, Marti A, Moreno-Aliaga MJ 2005 Serum and gene expression levels of leptin and adiponectin in rats susceptible or resistant to diet-induced obesity. J Physiol Biochem 61:333-342 (Pubitemid 41269257)
80. Yannakoulia M, Yiannakouris N, Blüher S, Matalas AL, Klimis-Zacas D, Mantzoros CS 2003 Body fat mass and macronutrient intake in relation to circulating soluble leptin receptor, free leptin index, adiponectin, and resistin concentrations in healthy humans. J Clin Endocrinol Metab 88:1730-1736 (Pubitemid 36623396)
81. Bullen Jr JW, Bluher S, Kelesidis T, Mantzoros CS 2007 Regulation of adiponectin and its receptors in response to development of diet-induced obesity in mice. Am J Physiol Endocrinol Metab 292: E1079-E1086 (Pubitemid 46536507)
82. Xue B, Rim JS, Hogan JC, Coulter AA, Koza RA, Kozak LP 2007 Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat. J Lipid Res 48:41-51 (Pubitemid 46052896)
83. Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR 2009 Identification and importance of brown adipose tissue in adult humans. N Engl J Med 360:1509-1517
84. van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, Drossaerts JM, Kemerink GJ, Bouvy ND, Schrauwen P, Teule GJ 2009 Cold-activated brown adipose tissue in healthy men. N Engl J Med 360:1500-1508
85. Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, Taittonen M, Laine J, Savisto NJ, Enerbäck S, Nuutila P 2009 Functional brown adipose tissue in healthy adults. N Engl J Med 360:1518-1525
86. Nedergaard J, Bengtsson T, Cannon B 2007 Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab 293:E444-E452 (Pubitemid 47205086)
87. Lidell ME, Enerbäck S 2010 Brown adipose tissue: a new role in humans? Nat Rev Endocrinol 6:319-325
88. Almind K, Manieri M, Sivitz WI, Cinti S, Kahn CR 2007 Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice. Proc Natl Acad Sci USA 104:2366-2371 (Pubitemid 46391403)
89. Guerra C, Koza RA, Yamashita H, Walsh K, Kozak LP 1998 Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity. J Clin Invest 102: 412-420 (Pubitemid 28335201)