Element imaging in formalin fixed slices of human mesencephalon

International Journal of Mass Spectrometry

Volumn 307, Issue 1-3, 2011, Pages 240-244

  Matusch, Andreas ^a   Bauer, Andreas ^a,b   Becker, J Sabine ^a  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Human brain tissue; LA ICP MS bioimaging; Metal imaging; Quantitative distribution analysis; Substantia nigra

Indexed keywords

EID: 79960711079     PISSN: 13873806     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijms.2011.03.006     Document Type: Article

References (20)

1. J. Stauber, R. Lemaire, J. Franck, D. Bonnel, D. Croix, R. Day, M. Wisztorski, I. Fournier, and M. Salzet MALDI imaging of formalin-fixed paraffin-embedded tissues: application to model animals of Parkinson disease for biomarker hunting J. Proteome Res. 7 2008 969 978
2. B. Popescu, M. George, U. Bergmann, A. Garachtchenko, M. Kelly, R. McCrea, K. Lüning, R. Devon, G. George, A. Hanson, S. Harder, L. Chapman, I. Pickering, and H. Nichol Mapping metals in Parkinson's and normal brain using rapid-scanning X-ray fluorescence Phys. Med. Biol. 54 2009 651 663
3. B.A. Faucheux, M.E. Martin, C. Beaumont, J.J. Hauw, Y. Agid, and E.C. Hirsch Neuromelanin associated redox-active iron is increased in the substantia nigra of patients with Parkinson's disease J. Neurochem. 86 2003 1142 1148 (Pubitemid 37022190)
4. A. Ektessabi, S. Yoshida, and K. Takada Distribution of iron in a single neuron of patients with Parkinson's disease X-Ray Spectrom. 28 1999 456 460
5. L. Zecca, M. Gallorini, V. Schunemann, A.X. Trautwein, M. Gerlach, P. Riederer, P. Vezzoni, and D. Tampellini Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes J. Neurochem. 76 2001 1766 1773 (Pubitemid 32221116)
6. D.T. Dexter, F.R. Wells, A.J. Lees, F. Agid, Y. Agid, P. Jenner, and C.D. Marsden Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease J. Neurochem. 52 1989 1830 1836 (Pubitemid 19140770)
7. J. Becker Inorganic Mass Spectrometry: Principles and Applications 2007 John Wiley and Sons Cichester
8. J.S. Becker, J. Dobrowolska, M. Zoriy, and A. Matusch Imaging of uranium on rat brain sections using laser ablation inductively coupled plasma mass spectrometry: a new tool for the study of critical substructures affined to heavy metals in tissues Rapid Commun. Mass. Spectrom. 22 2008 2768 2772
9. J.S. Becker, A. Matusch, C. Palm, D. Salber, K.A. Morton, and S. Becker Bioimaging of metals in brain tissue by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) and metallomics Metallomics 2 2010 104 111
10. J.S. Becker, M. Zoriy, A. Matusch, B. Wu, D. Salber, and C. Palm Bioimaging of metals by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) Mass Spectrom. Rev. 29 2010 156 175
11. J.S. Becker, M.V. Zoriy, C. Pickhardt, N. Palomero-Gallagher, and K. Zilles Imaging of copper, zinc, and other elements in thin section of human brain samples (hippocampus) by laser ablation inductively coupled plasma mass spectrometry Anal. Chem. 77 2005 3208 3216 (Pubitemid 40695477)
12. J. Dobrowolska, M. Dehnhardt, A. Matusch, M. Zoriy, N. Palomero-Gallagher, P. Koscielniak, K. Zilles, and J.S. Becker Quantitative imaging of zinc, copper and lead in three distinct regions of the human brain by laser ablation inductively coupled plasma mass spectrometry Talanta 74 2008 717 723
13. A. Matusch, C. Depboylu, C. Palm, B. Wu, G.U. Hoglinger, M.K. Schafer, and J.S. Becker Cerebral bioimaging of Cu, Fe, Zn, and Mn in the MPTP mouse model of Parkinson's disease using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) J. Am. Soc. Mass Spectrom. 21 2010 161 171
14. H. Braak, and E. Braak Neuropathological stageing of Alzheimer-related changes Acta Neuropathol. 82 1991 239 259
15. H. Braak, K. Del Tredici, H. Bratzke, J. Hamm-Clement, D. Sandmann-Keil, and U. Rüb Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages) J. Neurol. 249 2002 1 5
16. J.C. Jurchen, S.S. Rubakhin, and J.V. Sweedler MALDI-MS imaging of features smaller than the size of the laser beam J. Am. Soc. Mass Spectrom. 16 2005 1654 1659 (Pubitemid 41345157)
17. L. Zecca, T. Shima, A. Stroppolo, C. Goj, G.A. Battiston, R. Gerbasi, T. Sarna, and H.M. Swartz Interaction of neuromelanin and iron in substantia nigra and other areas of human brain Neuroscience 73 1996 407 415 (Pubitemid 26169932)
18. R.J. Uitti, A.H. Rajput, B. Rozdilsky, M. Bickis, T. Wollin, and W.K. Yuen Regional metal concentrations in Parkinson's disease, other chronic neurological diseases, and control brains Can. J. Neurol. Sci. 16 1989 310 314 (Pubitemid 19213592)
19. H Braak, and E. Braak Nuclear configuration and neuronal types of the nucleus niger in the brain of the human adult Hum. Neurobiol. 5 1986 71 82 (Pubitemid 16093811)
20. P. Damier, E.C. Hirsch, Y. Agid, and A.M. Graybiel The substantia nigra of the human brain. I. Nigrosomes and the nigral matrix, a compartmental organization based on calbindin D(28K) immunohistochemistry Brain 122 Pt. 8 1999 1421 1436 (Pubitemid 29374121)