Runs of homozygosity do not influence survival to old age

PLoS ONE

Volumn 6, Issue 7, 2011, Pages

  Kuningas, Maris ^a   McQuillan, Ruth ^b   Wilson, James F ^b   Hofman, Albert ^a,c   van Duijn, Cornelia M ^a,c   Uitterlinden, André G ^a,c   Tiemeier, Henning ^a,c,d  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c Netherlands Genomics Initiative   (Netherlands)

^d SOPHIA CHILDREN S HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; AUTOSOME; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; FOLLOW UP; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOME ANALYSIS; GENOME SIZE; GENOTYPE; HOMOZYGOSITY; HUMAN; LONGEVITY; MALE; RECESSIVE GENE; RUNS OF HOMOZYGOSITY; SENESCENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SURVIVAL; GENETICS; HOMOZYGOTE; MIDDLE AGED;

AGED; FEMALE; HOMOZYGOTE; HUMANS; LONGEVITY; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; SURVIVAL ANALYSIS;

EID: 79960706926     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0022580     Document Type: Article

References (10)

1. Lencz T, Lambert C, DeRosse P, Burdick KE, Morgan TV, et al. (2007) Runs of homozygosity reveal highly penetrant recessive loci in schizophrenia. Proc Natl Acad Sci U S A 104: 19942-19947.
2. McQuillan R, Leutenegger AL, Abdel-Rahman R, Franklin CS, Pericic M, et al. (2008) Runs of homozygosity in European populations. Am J Hum Genet 83: 359-372.
3. Gibson J, Morton NE, Collins A, (2006) Extended tracts of homozygosity in outbred human populations. Hum Mol Genet 15: 789-795.
4. Nalls MA, Guerreiro RJ, Simon-Sanchez J, Bras JT, Traynor BJ, et al. (2009) Extended tracts of homozygosity identify novel candidate genes associated with late-onset Alzheimer's disease. Neurogenetics 10: 183-190.
5. Yang TL, Guo Y, Zhang LS, Tian Q, Yan H, et al. (2010) Runs of homozygosity identify a recessive locus 12q21.31 for human adult height. J Clin Endocrinol Metab 95: 3777-3782.
6. Vine AE, McQuillin A, Bass NJ, Pereira A, Kandaswamy R, et al. (2009) No evidence for excess runs of homozygosity in bipolar disorder. Psychiatr Genet 19: 165-170.
7. Spain SL, Cazier J-B, Houlston R, Carvajal-Carmona L, et al. The CORGI Consortium (2009) Colorectal Cancer Risk Is Not Associated with Increased Levels of Homozygosity in a Population from the United Kingdom. Cancer Research 69: 7422-7429.
8. Hosking FJ, Papaemmanuil E, Sheridan E, Kinsey SE, Lightfoot T, et al. (2010) Genome-wide homozygosity signatures and childhood acute lymphoblastic leukemia risk. Blood 115: 4472-4477.
9. Hofman A, Breteler MM, van Duijn CM, Janssen HL, Krestin GP, et al. (2009) The Rotterdam Study: 2010 objectives and design update. Eur J Epidemiol 24: 553-572.
10. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, et al. (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81: 559-575.