Remote ischaemic conditioning before exercise: Are we there yet?

Heart

Volumn 97, Issue 16, 2011, Pages 1284-1285

  Lavi, Ronit ^a   Lavi, Shahar ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PADGEM PROTEIN;

ACUTE CORONARY SYNDROME; CORONARY ARTERY; CORONARY ARTERY DISEASE; DISEASE MODEL; EDITORIAL; EXERCISE; HEART INFARCTION; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HUMAN; ISCHEMIC HEART DISEASE; ISCHEMIC PRECONDITIONING; NONHUMAN; PRIORITY JOURNAL; ST SEGMENT DEPRESSION; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; THROMBOCYTE ACTIVATION; THROMBOCYTE FUNCTION; THROMBOSIS;

ARM; EXERCISE; FEMALE; HUMANS; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MALE; MYOCARDIAL ISCHEMIA; PLATELET ACTIVATION;

EID: 79960698324     PISSN: 13556037     EISSN: 1468201X     Source Type: Journal    
DOI: 10.1136/heartjnl-2011-300262     Document Type: Editorial

References (16)

1. Ross AM, Gibbons RJ, Stone GW, et al. A randomized, double-blinded, placebo-controlled multicenter trial of adenosine as an adjunct to reperfusion in the treatment of acute myocardial infarction (AMISTAD-II). J Am Coll Cardiol 2005;45:1775-80. (Pubitemid 40779856)
2. Piot C, Croisille P, Staat P, et al. Effect of cyclosporine on reperfusion injury in acute myocardial infarction. N Engl J Med 2008;359:473-81.
3. Lavi S, Lavi R. Conditioning of the heart: from pharmacological interventions to local and remote protection: possible implications for clinical practice. Int J Cardiol 2011;146:311-18.
4. Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 1986;74:1124-36. (Pubitemid 17174962)
5. Peart JN, Headrick JP. Clinical cardioprotection and the value of conditioning responses. Am J Physiol Heart Circ Physiol 2009;296:H1705-20.
6. Heusch G, Boengler K, Schulz R. Cardioprotection: nitric oxide, protein kinases, and mitochondria. Circulation 2008;118:1915-19.
7. Burwell LS, Brookes PS. Mitochondria as a target for the cardioprotective effects of nitric oxide in ischemia-reperfusion injury. Antioxid Redox Signal 2008;10:579-99.
8. Linden MD, Whittaker P, Frelinger AL 3rd, et al. Preconditioning ischemia attenuates molecular indices of platelet activation-aggregation. J Thromb Haemost 2006;4:2670-7. (Pubitemid 44741564)
9. Minamino T, Kitakaze M, Asanuma H, et al. Endogenous adenosine inhibits P-selectin-dependent formation of coronary thromboemboli during hypoperfusion in dogs. J Clin Invest 1998;101:1643-53. (Pubitemid 28198493)
10. Loukogeorgakis SP, Panagiotidou AT, Yellon DM, et al. Postconditioning protects against endothelial ischemia-reperfusion injury in the human forearm. Circulation 2006;113:1015-19. (Pubitemid 43879477)
11. Battipaglia I, Scalone G, Milo M, et al. Upper arm intermittent ischaemia reduces exercise-related increase of platelet reactivity in patients with obstructive coronary artery disease. Heart 2011;97:1298-303.
12. Kloner RA, Shook T, Przyklenk K, et al. Previous angina alters in-hospital outcome in TIMI 4: a clinical correlate to preconditioning? Circulation 1995;91:37-45.
13. Willich SN, Lewis M, Lowel H, et al. Physical exertion as a trigger of acute myocardial infarction. Triggers and Mechanisms of Myocardial Infarction Study Group. N Engl J Med 1993;329:1684-90. (Pubitemid 23346918)
14. Wallen NH, Held C, Rehnqvist N, et al. Effects of mental and physical stress on platelet function in patients with stable angina pectoris and healthy controls. Eur Heart J 1997;18:807-15. (Pubitemid 27208153)
15. Andreotti F, Lanza GA, Sciahbasi A, et al. Low-grade exercise enhances platelet aggregability in patients with obstructive coronary disease independently of myocardial ischemia. Am J Cardiol 2001;87:16-20. (Pubitemid 32013078)
16. Scalone G, Coviello I, Barone L, et al. Brief low-workload myocardial ischaemia induces protection against exercise-related increase of platelet reactivity in patients with coronary artery disease. Heart 2010;96:263-8.