Hydrogen inhalation is neuroprotective and improves functional outcomes in mice after intracerebral hemorrhage

Acta Neurochirurgica, Supplementum

Volumn , Issue 111, 2011, Pages 179-183

  Manaenko, Anatol ^a   Lekic, Tim ^a   Ma, Qingyi ^a   Ostrowski, Robert P ^a   Zhang, John H ^a   Tang, Jiping ^a  

^a LOMA LINDA UNIVERSITY   (United States)

Author keywords

Antioxidant; Brain edema; ICH; Neuroprotection; ROS

Indexed keywords

HYDROGEN; NEUROPROTECTIVE AGENT; COLLAGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BRAIN EDEMA; BRAIN HEMORRHAGE; BRAIN WATER; CONFERENCE PAPER; CONTROLLED STUDY; FUNCTIONAL ASSESSMENT; MALE; MOUSE; NEUROLOGIC EXAMINATION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; ANALYSIS OF VARIANCE; ANIMAL; ARTICLE; BRAIN; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG EFFECT; HEMISPHERIC DOMINANCE; INHALATIONAL DRUG ADMINISTRATION; MOTOR PERFORMANCE; NEUROLOGIC DISEASE; PATHOLOGY; PATHOPHYSIOLOGY; TIME;

ADMINISTRATION, INHALATION; ANALYSIS OF VARIANCE; ANIMALS; BRAIN; BRAIN EDEMA; CEREBRAL HEMORRHAGE; COLLAGENASES; DISEASE MODELS, ANIMAL; FUNCTIONAL LATERALITY; HYDROGEN; MALE; MICE; MOTOR SKILLS; NERVOUS SYSTEM DISEASES; NEUROLOGIC EXAMINATION; NEUROPROTECTIVE AGENTS; TIME FACTORS;

EID: 79960694058     PISSN: 00651419     EISSN: 00016268     Source Type: Book Series    
DOI: 10.1007/978-3-7091-0693-8_30     Document Type: Conference Paper

References (12)

1. Rojas H, Lekic T, Chen W, Jadhav V, Titova E, Martin RD, Tang H, Zhang J (2008) The antioxidant effects of melatonin after intracere-bral hemorrhage in rats. Acta Neurochir Suppl 105:19-21
2. Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S, Ohta S (2007) Hydrogen acts as therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 13:688-694 (Pubitemid 46889750)
3. Manaenko A, Lekic T, Sozen T, Tsuchiyama R, Zhang JH, Tang J (2009) Effect of gap junction inhibition on intracerebral hemor¬rhage-induced brain injury in mice. Neurol Res 31:173-178
4. Garcia JH, Wagner S, Liu KF, Hu XJ (1998) Neurological defcit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation. Stroke 29:871-872
5. Lekic T, Hartman R, Rojas H, Manaenko A, Chen W, Ayer R, Tang J, Zhang JH (2010) Protective effect of melatonin upon neuropathol-ogy, striatal function, and memory ability after intracerebral hemor¬rhage in rats. J Neurotrauma 27(3):627-637
6. Hayashida K, Sano M, Ohsawa I, Shinmura K Tamaki K, Kimura K, Endo J, Katayama T, Kawamira A, Kohsaka S, Makino S, Ohta S, Ogawa S, Fakuda K (2008) Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun 373(1):30-35
7. Wang J, Rogove AD, Tsirka AE, Tsirka SE (2003) Protective role of tuftsin fragment 1-3 in an animal model of intracerebral hemor¬rhage. Ann Neurol 54:655-664 (Pubitemid 37346072)
8. Gong C, Hoff JT, Keep RF (2000) Acute infammatory reaction following experimental intracerebral hemorrhage in rat. Brain Res 871:57-65 (Pubitemid 30406868)
9. Liao W, Zhong J, Yu J, Xie J, Liu Y, Du L, Yang S, Liu P, Xu J, Wang J, Han Z, Han ZC (2009) Therapeutic beneft of human umbilical cord derived mesenchymal stromal cells in intracerebral hemorrhage rat: implications of anti-infammation and angiogene-sis. Cell Physiol Biochem 24:307-316
10. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 39: 44-84 (Pubitemid 44566469)
11. Wu J, Hua Y, Keep RF, Nakamura T, Hoff JT, Xi G (2003) Iron and iron-handling proteins in the brain after intracerebral hemorrhage. Stroke 34:2964-2969 (Pubitemid 37517778)
12. Chan PH (1996) Role of oxidants in ischemic brain damage. Stroke 27:1124-1129 (Pubitemid 26177617)