Indomethacin impairs coronary perfusion in infants with hemodynamically significant ductus arteriosus

Neonatology

Volumn 101, Issue 1, 2011, Pages 20-27

  Sehgal, Arvind ^a,b   Ramsden, C Andrew ^a,b   McNamara, Patrick J ^c,d  

^a MONASH MEDICAL CENTRE   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

Coronary; Indomethacin; Neonates

Indexed keywords

INDOMETACIN;

ARTERIAL PRESSURE; ARTICLE; BIRTH WEIGHT; BLOOD FLOW VELOCITY; CORONARY ARTERY BLOOD FLOW; CORONARY HEMODYNAMICS; DUCTUS ARTERIOSUS; ECHOCARDIOGRAPHY; GESTATION PERIOD; HEART LEFT VENTRICLE; HUMAN; INFANT; LEFT ANTERIOR DESCENDING CORONARY ARTERY; OBSERVATIONAL STUDY; PREMATURITY; PRIORITY JOURNAL; PROSPECTIVE STUDY;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CORONARY CIRCULATION; DUCTUS ARTERIOSUS, PATENT; ECHOCARDIOGRAPHY; GESTATIONAL AGE; HEMODYNAMICS; HUMANS; INDOMETHACIN; INFANT; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, VERY LOW BIRTH WEIGHT; INJECTIONS, INTRAVENOUS; INTENSIVE CARE, NEONATAL; PROSPECTIVE STUDIES; REGIONAL BLOOD FLOW;

EID: 79960682403     PISSN: 16617800     EISSN: 16617819     Source Type: Journal    
DOI: 10.1159/000327844     Document Type: Article

References (45)

1. Ellison RC, Peckham GJ, Lang GJP, Talner NS, Lerer TJ, Lin L, et al: Evaluation of the preterm infant for patent ductus arteriosus. Pediatrics 1983; 71: 364-372. (Pubitemid 13144049)
2. Heymann MA, Rudolph AM, Silverman NH: Closure of the ductus arteriosus in premature infants by inhibition of prostaglandin synthesis. N Engl J Med 1976; 295: 530-533.
3. Friedman WF, Hirschklau MJ, Printz MP, Pitlick PT, Kirkpatrick SE: Pharmacologic closure of patent ductus arteriosus in the premature infants. N Engl J Med 1976; 295: 526-529.
4. Park MK, Kuehl TJ, Hayashi S: Differential effects of prostaglandins on mesenteric and cerebral arteries isolated from premature newborn baboons. Eur J Pediatr 1984; 146:61-62.
5. Coombs RC, Morgan MEI, Durbin GM, Booth IW, McNeish AS: Gut blood flow velocities in the newborn: effects of patent ductus arteriosus and indomethacin. Arch Dis Child 1990; 65: 1067-1071. (Pubitemid 20326329)
6. Feigen LP, King LW, Ray J, Beckett W, Kadowitz PJ: Differential effects of ibuprofen and indomethacin in the regional circulation of the dog. J Pharmacol Exp Ther 1981; 219; 679-684. (Pubitemid 12248827)
7. Cowan F: Indomethacin, patent ductus arteriosus and cerebral blood flow. J Pediatr 1986; 109: 341-343.
8. Akima S, Kent A, Reynolds GJ, Gallagher M, Falk MC: Indomethacin and renal impairment in neonates. Pediatr Nephrol 2004; 19: 490-495.
9. Afonso S, Bandow GT, Rowe GG: Indomethacin and the prostaglandin hypothesis of coronary blood flow regulation. J Physiol 1974; 241: 299-308.
10. Kluckow M, Evans N: Early echocardiographic prediction of symptomatic patent ductus arteriosus in preterm infants undergoing mechanical ventilation. J Pediatr 1995; 127: 774-779.
11. White WB: Heart rate and the rate-pressure product as determinants of cardiovascular risk in patients with hypertension. Am J Hypertens 1999; 12: 50S-55S. (Pubitemid 29144994)
12. Bel FV, Zoeren DV, Schipper J, Gult GL, Baan J: Effect of indomethacin on superior mesenteric artery blood flow velocity in preterm infants. J Pediatr 1990; 116: 965-970. (Pubitemid 20201712)
13. Oskarsson G, Pesonen E: Coronary blood flow in healthy neonates: Effects of left ventricular function and mass. Pediatr Cardiol 2004; 25: 11-16. (Pubitemid 38140849)
14. Sehgal A, McNamara PJ: Coronary artery hypo-perfusion is associated with impaired diastolic dysfunction in preterm infants after patent ductus arteriosus (PDA) ligation. Pediatric Academic Societies Annual Meeting, Toronto E-PAS, 2007, p 615896.15.
15. Harada K, Tamura M, Orino T, Yasuoka K: Coronary blood flow assessed by transthoracic echocardiography in neonates. Pediatr Cardiol 2001; 22: 189-193. (Pubitemid 32303894)
16. Silverman NH, Schiller NB: Cross sectional echocardiographic assessment of cardiac chamber size and ejection fraction in children. Ultrasound Med Biol 1984; 10: 757-769. (Pubitemid 15103336)
17. Kluckow M, Evans N: Superior vena cava flow in newborn infants: a novel marker of systemic blood flow. Arch Dis Child Fetal Neonatal Ed 2000; 82:F182-F187. (Pubitemid 30313551)
18. Smallhorn JF, Gow R, Olley PM, Freedom RM, Swyer PR, Perlman M, et al: Combined noninvasive assessment of the patent ductus arteriosus in the preterm infant before and after indomethacin treatment. Am J Cardiol 1984; 54: 1300-1304.
19. Oskarsson G, Pesonen E: Coronary blood flow abnormalities in neonates with aortic stenosis. J Pediatr 2000; 137: 875-877.
20. Hozumi T, Yoshida K, Akasaka T Asami Y, Ogata Y, Takagi T, et al: Non-invasive assessment of coronary flow velocity and coronary flow velocity reserve in the left anterior descending coronary artery by Doppler echocardiography: comparison with invasive technique. J Am Coll Cardiol 1998; 32: 1251-1259. (Pubitemid 28522380)
21. Yasuoka K, Harada K, Orino T, Tamura M, Takada G: Left anterior descending coronary artery flow and its relation to age in children. J Am Echocardiogr 2002; 15: 69-75. (Pubitemid 44964485)
22. Harling S, Oskarsson G, Gudmundsson S, Pesonen E: Acute decrease of coronary flow after indomethacin delivery in newborn lambs. Acta Paediatrica 2007; 96: 1460-1463. (Pubitemid 47416429)
23. Raud J, Dahlen SE, Sydbom A, Lindbom L, Hedqvist P: Enhancement of acute allergic inflammation by indomethacin is reversed by prostaglandin E 2 : apparent correlation with in vivo modulation of mediator release. Proc Natl Acad Sci USA 1988; 85: 2315-2319. (Pubitemid 24315882)
24. König W, Brom J, Schönfeld A, Knoller J, Stuning M: Effect of tenoxicam and indomethacin on the release of histamine, prostaglandin E 2 , and leukotrienes from various cells. Arzneimittelforschung 1987; 37: 296-299.
25. Pourcyrous M, Leffler CW, Bada HS, Korones SB, Busija DW: Brain superoxide anion generation in asphyxiated piglets and the effect of indomethacin at therapeutic dose. Pediatr Res 1993; 34: 366-369. (Pubitemid 23254560)
26. Kadowitz PJ, Sweet CS, Brody MJ: Influence of prostaglandins on adrenergic transmission to vascular smooth muscle. Circ Res 1972; 30: 11-36.
27. Arnold G, Kosche F, Miessner E, Neitzert A, Lochner W: The importance of the perfusion pressure in the coronary arteries for the contractility and the oxygen consumption of the heart. Pflügers Arch Gesamte Physiol Menschen Tiere 1968; 299: 339-356.
28. Way GL, Pierce JR, Wolfe RR, McGrath R, Wiggins J, Merenstein GB: ST depression suggesting subendocardial ischemia in neonates with respiratory distress syndrome and patent ductus arteriosus. J Pediatr 1979; 95: 609.
29. El-Khuffash AF, Molloy EJ: Influence of a patent ductus arteriosus on cardiac troponin T levels in preterm infants. J Pediatr 2008; 153: 350-353
30. Friedman PL, Brown EJ, Gunther S, Alexander RW, Barry WH, Mudge GH Jr, et al: Coronary vasoconstrictor effect of indomethacin in patients with coronary artery disease. N Engl J Med 1981; 305: 1171.
31. Klautz RJM, van Bel F, Teitel DF, Steenduk P, Baan J: Myocardial perfusion and performance after indomethacin administration in newborn lambs. Padiatr Res 1993; 33: 295-301. (Pubitemid 23101845)
32. Evans DH, Levene MI, Archer LN: The effect of indomethacin on cerebral blood-flow velocity in premature infants. Dev Med Child Neurol 1987; 29: 776-782.
33. Leffler CW, Busija DW, Beasley DJ: Effect of therapeutic dose of indomethacin on the cerebral circulation of newborn pigs. Pediatr Res 1987; 21: 188-192. (Pubitemid 17015223)
34. Christmann V, Liem KD, Semmekrot BA, van de Bor M: Changes in cerebral, renal and mesenteric blood velocity after continuos and bolus infusion of indomethacin. Acta Paediatr 2002; 91: 440-446. (Pubitemid 34478198)
35. Appleton RS, Graham TP, Cotton RB, Moreau GA, Boucek RJ: Decreased early diastolic function after indomethacin administration in premature infants. J Pediatr 1988; 112: 447-451. (Pubitemid 18079834)
36. Uemura S, Nakanishi T, Matsouka S, Friedman WF, Jarmakani JM: Inotropic effects of prostaglandin D2 and E1 on the newborn rabbit heart. Pediatr Res 1984; 18: 1277.
37. Reduto LA, Wickemeyer W J, Yound JB, et al: Left ventricular diastolic performance at rest and during exercise in patients with coronary artery disease. Circulation 1981; 63: 1228.
38. Schabelman SE, Schabelman F, Brundage BH, Willis WH: Detection of diastolic left ventricular function abnormalities in patients with coronary artery disease and normal systolic function. Clin Cardiol 1983; 6: 292.
39. Yanowitz TD, Yao AC, Werner JC, Pettigrew KD, Oh W, Stonestreet BS: Effects of prophylactic low-dose indomethacin on hemodynamics in very low birth weight infants. J Pediatr 1998; 132: 28-34. (Pubitemid 28082527)
40. Portman MA, Ning XH: Myocardial energy metabolism in the newborn lamb in vivo during pacing-induced changes in oxygen consumption. Pediatr Res 1995; 37: 182-187.
41. Shaddy RE, Tyndall M, Teitel D Li C, Mills A, Rudolph AM: The effects of changes in heart rate and aortic systolic pressure on left ventricular myocardial oxygen consumption in lambs. J Dev Physiol 1989; 11: 213-217. (Pubitemid 19249505)
42. Olson KR, Whitfield NL: Hydrogen sulfide and oxygen sensing in the cardiovascular system. Antioxid Redox Signal 2010; 12: 1219-1234.
43. Larsen BT, Gutterman DD, Sato A, Toyama K, Campbell WB, Zeldin DC, et al: Hydrogen peroxide inhibits cytochrome p450 epoxygenases: interaction between two endothelium-derived hyperpolarizing factors. Circ Res 2008; 102: 59-67.
44. 2 activates redox-and 4-aminopyridine-sensitive Kv channels in coronary vascular smooth muscle. Am JPhysiol Heart Circ Physiol 2007; 292:H1404-H1411. (Pubitemid 46377128)
45. Brzezinska AK, Merkus D, Chilian WM: Metabolic communication from cardiac myocytes to vascular endothelial cells. Am J Physiol Heart Circ Physiol 2005; 288:H2232-H2237. (Pubitemid 40604110)