Clot formation, vascular repair and hematoma resolution after ICH, a coordinating role for thrombin?

Acta Neurochirurgica, Supplementum

Volumn , Issue 111, 2011, Pages 71-75

  Keep, Richard F ^a,b   Xi, G ^a   Hua, Y ^a   Xiang, J ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Coagulation; Hematoma resolution; Iron handling proteins; Thrombin; Vascular repair

Indexed keywords

BLOOD CLOTTING FACTOR 13; BLOOD CLOTTING FACTOR 7A; PLASMINOGEN ACTIVATOR INHIBITOR; PROTEASE NEXIN I; THROMBIN;

ASTROCYTE; BLOOD CLOT LYSIS; BLOOD CLOTTING; BRAIN HEMATOMA; BRAIN HEMORRHAGE; BRAIN INJURY; CELL PROLIFERATION; CONFERENCE PAPER; HUMAN; NEUROMODULATION; NONHUMAN; PHAGOCYTE; REGULATORY MECHANISM; UPREGULATION; ANIMAL; HEMATOMA; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; WOUND HEALING;

ANIMALS; BLOOD COAGULATION; CEREBRAL HEMORRHAGE; HEMATOMA; HUMANS; THROMBIN; WOUND HEALING;

EID: 79960682174     PISSN: 00651419     EISSN: 00016268     Source Type: Book Series    
DOI: 10.1007/978-3-7091-0693-8_12     Document Type: Conference Paper

References (31)

1. Wu J, Hua Y, Keep RF, Nakamura T, Hoff JT, Xi G (2003) Iron and iron-handling proteins in the brain after intracerebral hemorrhage. Stroke 34:2964-2969 (Pubitemid 37517778)
2. Mayer SA, Brun NC, Begtrup K, Broderick J, Davis S, Diringer MN, Skolnick BE, Steiner T (2008) Effcacy and safety of recombi-nant activated factor VII for acute intracerebral hemorrhage. N Engl J Med 358:2127-2137 (Pubitemid 351679599)
3. Mendelow AD, Unterberg A (2007) Surgical treatment of intra-cerebral haemorrhage. Curr Opin Crit Care 13:169-174
4. Zhao X, Sun G, Zhang J, Strong R, Song W, Gonzales N, Grotta JC, Aronowski J (2007) Hematoma resolution as a target for intracere-bral hemorrhage treatment: role for peroxisome proliferator-acti-vated receptor gamma in microglia/macrophages. Ann Neurol 61: 352-362 (Pubitemid 46676735)
5. Hua Y, Nakamura T, Keep RF, Wu J, Schallert T, Hoff JT, Xi G (2006) Long-term effects of experimental intracerebral hemor¬rhage: the role of iron. J Neurosurg 104:305-312
6. Xi G, Keep RF, Hoff JT (2006) Mechanisms of brain injury after intracerebral haemorrhage. Lancet Neurol 5:53-63 (Pubitemid 41790696)
7. Huttner HB, Steiner T (2010) Coagulopathy-related intracerebral hemorrhage. In: Carhuapoma JR, Mayer SA, Hanley DF (eds) Intracerebral hemorrhage. Cambridge University Press, Cambridge, pp 58-70
8. Dolinskas CA, Bilaniuk LT, Zimmerman RA, Kuhl DE (1977) Computed tomography of intracerebral hematomas. I. Transmission CT observations on hematoma resolution. Am J Roentgenol 129:681-688 (Pubitemid 8197938)
9. Xi G, Reiser G, Keep RF (2003) The role of thrombin and thrombin receptors in ischemic, hemorrhagic and traumatic brain injury: del¬eterious or protective? J Neurochem 84:3-9 (Pubitemid 36182060)
10. Hristov M, Weber C, Hristov M, Weber C (2008) Endothelial progenitor cells in vascular repair and remodeling. Pharm Res 58:148-151
11. Urbich C, Dimmeler S, Urbich C, Dimmeler S (2004) Endothelial progenitor cells: characterization and role in vascular biology. Circ Res 95:343-353 (Pubitemid 39100452)
12. Nagy Z, Kolev K, Csonka E, Pek M, Machovich R (1995) Contraction of human brain endothelial cells induced by thrombo-genic and fbrinolytic factors. An in vitro cell culture model. Stroke 26:265-270
13. Shatos MA, Orfeo T, Doherty JM, Penar PL, Collen D, Mann KG (1995) Alpha-thrombin stimulates urokinase production and DNA synthesis in cultured human cerebral microvascular endothelial cells. Arterioscler Thromb Vasc Biol 15:903-911
14. Cavanaugh KP, Gurwitz D, Cunningham DD, Bradshaw RA (1990) Reciprocal modulation of astrocyte stellation by thrombin and pro¬tease nexin-1. J Neurochem 54:1735-1743
15. Dodge AB, Hechtman HB, Shepro D (1991) Microvascular endothelial-derived autacoids regulate pericyte contractility. Cell Motil Cytoskeleton 18:180-188
16. Stouffer GA, Runge MS (1998) The role of secondary growth factor production in thrombin-induced proliferation of vascular smooth muscle cells. Sem Thromb Hemost 24:145-150 (Pubitemid 28180824)
17. Yang S, Song S, Hua Y, Nakamura T, Keep RF, Xi G (2008) Effects of thrombin on neurogenesis after intracerebral hemorrhage. Stroke 39:2079-2084
18. Masuda T, Dohrmann GJ, Kwaan HC, Erickson RK, Wollman RL (1988) Fibrinolytic activity in experimental intracerebral hema-toma. J Neurosurg 68:274-278 (Pubitemid 18057736)
19. Mendelow AD, Gregson BA, Fernandes HM, Murray GD, Teasdale GM, Hope DT, Karimi A, Shaw MD, Barer DH (2005) Early sur¬gery versus initial conservative treatment in patients with spontane¬ous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial. Lancet 365:387-397 (Pubitemid 40179225)
20. Hua Y, Xi G, Keep RF, Hoff JT (2000) Complement activation in the brain after experimental intracerebral hemorrhage. J Neurosurg 92:1016-1022 (Pubitemid 30346522)
21. Zhao X, Grotta J, Gonzales N, Aronowski J, Zhao X, Grotta J, Gonzales N, Aronowski J (2009) Hematoma resolution as a therapeu¬tic target: the role of microglia/macrophages. Stroke 40:S92-S94
22. Eastman D, Wurm FM, van Reis R, Higgins DL (1992) A region of tissue plasminogen activator that affects plasminogen activation dif¬ferentially with various fbrin(ogen)-related stimulators. Biochemistry 31:419-422
23. Gong Y, Xi GH, Keep RF, Hoff JT, Hua Y (2005) Complement inhibition attenuates brain edema and neurological defcits induced by thrombin. Acta Neurochir Suppl 95:389-392
24. Hua Y, Keep RF, Hoff JT, Xi G (2003) Thrombin preconditioning attenuates brain edema induced by erythrocytes and iron. J Cereb Blood Flow Metab 23:1448-1454 (Pubitemid 38018263)
25. Wagner KR, Sharp FR, Ardizzone TD, Lu A, Clark JF, Wagner KR, Sharp FR, Ardizzone TD, Lu A, Clark JF (2003) Heme and iron metabolism: role in cerebral hemorrhage. J Cereb Blood Flow Metab 23:629-652 (Pubitemid 36713668)
26. Wu H, Zhao R, Qi J, Cong Y, Wang D, Liu T, Gu Y, Ban X, Huang Q, Wu H, Zhao R, Qi J, Cong Y, Wang D, Liu T, Gu Y, Ban X, Huang Q (2008) The expression and the role of protease nexin-1 on brain edema after intracerebral hemorrhage. J Neurol Sci 270:172-183
27. Hua Y, Xi G, Keep RF, Wu J, Jiang Y, Hoff JT (2002) Plasmino-gen activator inhibitor-1 induction after experimental intracerebral hemorrhage. J Cereb Blood Flow Metab 22:55-61 (Pubitemid 34038383)
28. Liu CY, Nossel HL, Kaplan KL (1979) The binding of thrombin by fbrin. J Biol Chem 254:10421-10425
29. Lee KR, Colon GP, Betz AL, Keep RF, Kim S, Hoff JT (1996) Edema from intracerebral hemorrhage: the role of thrombin. J Neurosurg 84:91-96 (Pubitemid 26007002)
30. Kitaoka T, Hua Y, Xi G, Hoff JT, Keep RF (2002) Delayed arga-troban treatment reduces edema in a rat model of intracerebral hem¬orrhage. Stroke 33:3012-3018 (Pubitemid 35462880)
31. Morgenstern LB, Demchuk AM, Kim DH, Frankowski RF, Grotta JC (2001) Rebleeding leads to poor outcome in ultra-early craniotomy for intracerebral hemorrhage. Neurology 56:1294-1299 (Pubitemid 32455286)