Hemoglobin expression in neurons and glia after intracerebral hemorrhage

Acta Neurochirurgica, Supplementum

Volumn , Issue 111, 2011, Pages 133-137

  He, Yangdong ^a   Hua, Ya ^a   Keep, Richard F ^a   Liu, Wenquan ^a   Wang, Michael M ^a   Xi, Guohua ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Deferxomine; Hemin; Hemoglobin; Intracerebral hemorrhage; Iron

Indexed keywords

ALPHA GLOBIN; BETA GLOBIN; DEFEROXAMINE; HEMIN; HEMOGLOBIN; IRON; MESSENGER RNA; SIDEROPHORE;

ANIMAL EXPERIMENT; ANIMAL MODEL; BASAL GANGLION; BRAIN HEMORRHAGE; CONFERENCE PAPER; CONTROLLED STUDY; GLIA; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; NERVE CELL; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SHAM PROCEDURE; UPREGULATION; ANIMAL; ANIMAL EMBRYO; ARTICLE; CELL CULTURE; DISEASE MODEL; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NONPARAMETRIC TEST; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; CELLS, CULTURED; CEREBRAL HEMORRHAGE; DEFEROXAMINE; DISEASE MODELS, ANIMAL; EMBRYO, MAMMALIAN; GENE EXPRESSION REGULATION; HEMIN; HEMOGLOBINS; MALE; NEUROGLIA; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SIDEROPHORES; STATISTICS, NONPARAMETRIC;

EID: 79960665810     PISSN: 00651419     EISSN: 00016268     Source Type: Book Series    
DOI: 10.1007/978-3-7091-0693-8_22     Document Type: Conference Paper

References (24)

1. Poyart C, Wajcman H, Kister J (1992) Molecular adaptation of hemoglobin function in mammals. Respir Physiol 90:3-17
2. Liu L, Zeng M, Stamler JS (1999) Hemoglobin induction in mouse macrophages. Proc Natl Acad Sci USA 96:6643-6647 (Pubitemid 29274936)
3. Newton DA, Rao KM, Dluhy RA, Baatz JE (2006) Hemoglobin is expressed by alveolar epithelial cells. J Biol Chem 281:5668-5676 (Pubitemid 43847664)
4. Nishi H, Inagi R, Kato H, Tanemoto M, Kojima I, Son D, Fujita T, Nangaku M (2008) Hemoglobin is expressed by mesangial cells and reduces oxidant stress. J Am Soc Nephrol 19:1500-1508
5. He Y, Hua Y, Liu W, Hu H, Keep RF, Xi G (2009) Effects of cere¬bral ischemia on neuronal hemoglobin. J Cereb Blood Flow Metab 29:596-605
6. Ohyagi Y, Yamada T, Goto I (1994) Hemoglobin as a novel protein developmentally regulated in neurons. Brain Res 635:323-327 (Pubitemid 24031420)
7. Richter F, Meurers BH, Zhu C, Medvedeva VP, Chesselet MF (2009) Neurons express hemoglobin alpha-and beta-chains in rat and human brains. J Comp Neurol 515:538-547
8. Schelshorn DW, Schneider A, Kuschinsky W, Weber D, Kruger C, Dittgen T, Burgers HF, Sabouri F, Gassler N, Bach A, Maurer MH (2009) Expression of hemoglobin in rodent neurons. J Cereb Blood Flow Metab 29:585-595
9. Xi G, Keep RF, Hoff JT (1998) Erythrocytes and delayed brain edema formation following intracerebral hemorrhage in rats. J Neurosurg 89:991-996 (Pubitemid 28544054)
10. Huang FP, Xi G, Keep RF, Hua Y, Nemoianu A, Hoff JT (2002) Brain edema after experimental intracerebral hemorrhage: role of hemoglobin degradation products. J Neurosurg 96:287-293 (Pubitemid 34230243)
11. Sadrzadeh SM, Anderson DK, Panter SS, Hallaway PE, Eaton JW (1987) Hemoglobin potentiates central nervous system damage. J Clin Invest 79:662-664 (Pubitemid 17009711)
12. Regan RF, Panter SS (1993) Neurotoxicity of hemoglobin in corti¬cal cell culture. Neurosci Lett 153:219-222 (Pubitemid 23147074)
13. Wang X, Mori T, Sumii T, Lo EH (2002) Hemoglobin-induced cytotoxicity in rat cerebral cortical neurons: caspase activation and oxidative stress. Stroke 33:1882-1888 (Pubitemid 34761080)
14. Jiang Y, Wu J, Hua Y, Keep RF, Xiang J, Hoff JT, Xi G (2002) Thrombin-receptor activation and thrombin-induced brain toler¬ance. J Cereb Blood Flow Metab 22:404-410 (Pubitemid 34273596)
15. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expres¬sion data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402-408 (Pubitemid 34164012)
16. Xi G, Keep RF, Hua Y, Xiang J, Hoff JT (1999) Attenuation of thrombin-induced brain edema by cerebral thrombin precondition¬ing. Stroke 30:1247-1255 (Pubitemid 29259182)
17. Wagner KR, Sharp FR, Ardizzone TD, Lu A, Clark JF (2003) Heme and iron metabolism: role in cerebral hemorrhage. J Cereb Blood Flow Metab 23:629-652 (Pubitemid 36713668)
18. Tahara T, Sun J, Igarashi K, Taketani S (2004) Heme-dependent up-regulation of the alpha-globin gene expression by transcriptional repressor Bach1 in erythroid cells. Biochem Biophys Res Commun 324:77-85 (Pubitemid 39311462)
19. Tahara T, Sun J, Nakanishi K, Yamamoto M, Mori H, Saito T, Fujita H, Igarashi K, Taketani S (2004) Heme positively regulates the expression of beta-globin at the locus control region via the transcriptional factor Bach1 in erythroid cells. J Biol Chem 279: 5480-5487 (Pubitemid 38220572)
20. Fibach E, Kollia P, Schechter AN, Noguchi CT, Rodgers GP (1995) Hemin-induced acceleration of hemoglobin production in immature cultured erythroid cells: preferential enhancement of fetal hemoglo¬bin. Blood 85:2967-2974
21. Rutherford TR, Clegg JB, Weatherall DJ (1979) K562 human leu-kaemic cells synthesise embryonic haemoglobin in response to hae-min. Nature 280:164-165 (Pubitemid 9221749)
22. Zhu Y, Sun Y, Jin K, Greenberg DA (2002) Hemin induces neuro-globin expression in neural cells. Blood 100:2494-2498
23. Wu J, Hua Y, Keep RF, Nakamura T, Hoff JT, Xi G (2003) Iron and iron-handling proteins in the brain after intracerebral hemorrhage. Stroke 34:2964-2969 (Pubitemid 37517778)
24. Vincent SR, Das S, Maines MD (1994) Brain heme oxygenase isoenzymes and nitric oxide synthase are co-localized in select neu¬rons. Neuroscience 63:223-231 (Pubitemid 24333963)