Tranexamic acid for traumatic brain injury: New data justify a re-evaluation in other types of intracranial haemorrhage

BMJ

Volumn 343, Issue 7816, 2011, Pages

  Roos, Yvo B W E M ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT;

ANEURYSM CLIP; BRAIN HEMORRHAGE; BRAIN INFARCTION; BRAIN ISCHEMIA; COMPUTER ASSISTED TOMOGRAPHY; DRUG SAFETY; EDITORIAL; HUMAN; MORTALITY; PRIORITY JOURNAL; RISK REDUCTION; SUBARACHNOID HEMORRHAGE; TRAUMATIC BRAIN INJURY; BRAIN INJURY; FEMALE; MALE; NOTE;

ANTIFIBRINOLYTIC AGENTS; BRAIN INJURIES; FEMALE; HUMANS; INTRACRANIAL HEMORRHAGES; MALE; TRANEXAMIC ACID;

EID: 79960665077     PISSN: None     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.d3958     Document Type: Editorial

References (7)

1. Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 2010;376:23-32.
2. Roos YB, Rinkel GJ, Vermeulen M, Algra A, van Gijn J. Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev 2003;2:CD001245.
3. CRASH-2 Collaborators (Intracranial Bleeding Study). Effect of tranexamic acid in traumatic brain injury: a nested randomised, placebo controlled trial (CRASH-2 Intracranial Bleeding Study). BMJ 2011;343:d3795.
4. Roos Y. Antifibrinolytic treatment in subarachnoid hemorrhage: a randomized placebo-controlled trial. STAR Study Group. Neurology 2000;54:77-82. (Pubitemid 30038741)
5. Vergouwen MD, Vermeulen M, van Gijn J, Rinkel GJ, Wijdicks EF, Muizelaar JP, et al. Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group. Stroke 2010;41:2391-5.
6. Hillman J, Fridriksson S, Nilsson O, Yu Z, Saveland H, Jakobsson KE. Immediate administration of tranexamic acid and reduced incidence of early rebleeding after aneurysmal subarachnoid hemorrhage: a prospective randomized study. J Neurosurg 2002;97:771-8. (Pubitemid 35222396)
7. Brott T, Broderick J, Kothari R, Barsan W, Tomsick T, Sauerbeck L, et al. Early hemorrhage growth in patients with intracerebral hemorrhage. Stroke 1997;28:1-5. (Pubitemid 27039454)