Immunovirological response to combined antiretroviral therapy and drug resistance patterns in children: 1- and 2-year outcomes in rural Uganda

BMC Pediatrics

Volumn 11, Issue , 2011, Pages

  Ahoua, Laurence ^a   Guenther, Gunar ^a   Rouzioux, Christine ^b   Pinoges, Loretxu ^a   Anguzu, Paul ^c   Taburet, Anne Marie ^d   Balkan, Suna ^c   Olson, David M ^c   Olaro, Charles ^e   Pujades Rodríguez, Mar ^a  

^a Clinical Research Department   (France)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

^c MÉDECINS SANS FRONTIÈRES   (Switzerland)

^d BICÊTRE HOSPITAL   (France)

^e Arua Regional Referral Hospital   (Uganda)

Author keywords

Antiretroviral therapy; Children; Drug resistance; Patient compliance; Pharmacokinetics; Ugandarural population

Indexed keywords

ABACAVIR; ANTIRETROVIRUS AGENT; DIDANOSINE; LAMIVUDINE PLUS NEVIRAPINE PLUS ZIDOVUDINE; LOPINAVIR; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; VIRUS RNA; ZIDOVUDINE; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ABDOMINAL FAT; ADOLESCENT; ARTICLE; CD4 LYMPHOCYTE COUNT; CHILD; DRUG BLOOD LEVEL; DRUG RESISTANCE; FEMALE; GASTROINTESTINAL SYMPTOM; HEALTH SURVEY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFANT; MAJOR CLINICAL STUDY; MALE; NEUTROPENIA; PATIENT CARE; PATIENT COMPLIANCE; PERIPHERAL NEUROPATHY; PRESCHOOL CHILD; RURAL AREA; SCHOOL CHILD; SIDE EFFECT; TREATMENT OUTCOME; UGANDA; VIRUS LOAD; ANTIVIRAL RESISTANCE; BLOOD; COHORT ANALYSIS; CROSS-SECTIONAL STUDY; DRUG COMBINATION; FOLLOW UP; RETROSPECTIVE STUDY; RURAL POPULATION; VIROLOGY;

ANTI-RETROVIRAL AGENTS; CD4 LYMPHOCYTE COUNT; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; CROSS-SECTIONAL STUDIES; DRUG RESISTANCE, VIRAL; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; HIV INFECTIONS; HUMANS; MALE; RETROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE INHIBITORS; RNA, VIRAL; RURAL POPULATION; UGANDA;

EID: 79960663234     PISSN: None     EISSN: 14712431     Source Type: Journal    
DOI: 10.1186/1471-2431-11-67     Document Type: Article

References (52)

1. UNICEF, UNAIDS, WHO, UNFPA and UNESCO Children and AIDS: Fifth Stocktaking Report, 2010, Geneva, Switzerland 2010, UNICEF, UNAIDS, WHO, UNFPA and UNESCO.
2. UNAIDS Global Report: UNAIDS Report on the Global AIDS Epidemic 2010, Geneva, Switzerland 2010, UNAIDS.
3. Brahmbhatt H, Kigozi G, Wabwire-Mangen F, Serwadda D, Lutalo T, Nalugoda F, Sewankambo N, Kiduggavu M, Wawer M, Gray R. Mortality in HIV-infected and uninfected children of HIV-infected and uninfected mothers in rural Uganda. J Acquir Immune Defic Syndr 2006, 41(4):504-508. 10.1097/01.qai.0000188122.15493.0a, 16652060.
4. Chesney M. Adherence to HAART regimens. AIDS Patient Care STDS 2003, 17(4):169-177. 10.1089/108729103321619773, 12737640.
5. Machado ES, Lambert JS, Afonso AO, Cunha SM, Oliveira RH, Tanuri A, Sill AM, Costa AJ, Soares MA. Alternative, age- and viral load-related routes of nelfinavir resistance in human immunodeficiency virus type 1-infected children receiving highly active antiretroviral therapy. Pediatr Infect Dis J 2004, 23(11):1057-1059. 10.1097/01.inf.0000145874.88351.0f, 15545865.
6. Eshleman SH, Jackson JB. Nevirapine resistance after single dose prophylaxis. AIDS Rev 2002, 4(2):59-63.
7. Eshleman SH, Krogstad P, Jackson JB, Wang YG, Lee S, Wei LJ, Cunningham S, Wantman M, Wiznia A, Johnson G, Nachman S, Palumbo P. Analysis of human immunodeficiency virus type 1 drug resistance in children receiving nucleoside analogue reverse-transcriptase inhibitors plus nevirapine, nelfinavir, or ritonavir (Pediatric AIDS Clinical Trials Group 377). J Infect Dis 2001, 183(12):1732-1738. 10.1086/320728, 11372025.
8. Fraaij PL, van Kampen JJ, Burger DM, de GR. Pharmacokinetics of antiretroviral therapy in HIV-1-infected children. Clin Pharmacokinet 2005, 44(9):935-956. 10.2165/00003088-200544090-00004, 16122281.
9. Jaspan HB, Berrisford AE, Boulle AM. Two-year outcomes of children on non-nucleoside reverse transcriptase inhibitor and protease inhibitor regimens in a South african pediatric antiretroviral program. Pediatr Infect Dis J 2008, 27(11):993-998. 10.1097/INF.0b013e31817acf7b, 18818556.
10. Reddi A, Leeper SC, Grobler AC, Geddes R, France KH, Dorse GL, Vlok WJ, Mntambo M, Thomas M, Nixon K, Holst HL, Karim QA, Rollins NC, Coovadia HM, Giddy J. Preliminary outcomes of a paediatric highly active antiretroviral therapy cohort from KwaZulu-Natal, South Africa. BMC Pediatr 2007, 7:13. 10.1186/1471-2431-7-13, 1847430, 17367540.
11. Batallan A, Moreau G, Levine M, Longuet P, Bodard M, Matheron S. In utero exposure to Efavirenz: evaluation in children born alive. 2nd International AIDS Society Conference on HIV pathogenesis and treatment, Paris, France 2003,
12. Docze A, Benca G, Augustin A, Liska A, Beno P, Babela O, Krcmery V. Is antimicrobial multiresistance to antibiotics in Cambodian HIV-positive children related to prior antiretroviral or tuberculosis chemotherapy?. Scand J Infect Dis 2004, 36(10):779-780.
13. Balkan S, Ciaffi L, Szumilin E. [Antiretroviral Treatment Protocol for Adults and Adolescents]. MSF-France (medical department), MSF-Suisse (medical department) (editors) 2006, 1-45. Paris: Médecins Sans Frontières.
14. WHO HIV/AIDS Programme. Strengthening health services to fight HIV/AIDS. Antiretroviral Therapy For HIV Infection in Adults and Adolescents: Recommendations for a public health approach. 2006 revision. Geneva 2009, WHO.
15. Rouet F. Transfer and evaluation of an automated, low-cost real-time reverse transcription-PCR test for diagnosis and monitoring of human immunodeficiency virus type 1 infection in a West African resource-limited setting. J Clin Microbiol 2005, 43(6):2709-2717. 10.1128/JCM.43.6.2709-2717.2005, 1151915, 15956387.
16. Descamps D. French national sentinel survey of antiretroviral drug resistance in patients with HIV-1 primary infection and in antiretroviral-naïve chronically infected patients in 2001-2002. J Acquir Immune Defic Syndr 2005, 38(5):545-552. 10.1097/01.qai.0000155201.51232.2e, 15793364.
17. The French National Agency for AIDS Research AC11 Resistance group HIV-1 Resistance group. HIV-1 genotypic drug resistance interpretation algorithms. 2005 2007, The French National Agency for AIDS Research AC11 Resistance group.
18. Wu EY, Wilkinson JM, Naret DG, Daniels VL, Williams LJ, Khalil DA, Shetty BV. High-performance liquid chromatographic method for the determination of nelfinavir, a novel HIV-1 protease inhibitor, in human plasma. J Chromatogr B Biomed Sci Appl 1997, 695(2):373-380. 10.1016/S0378-4347(97)00193-X, 9300874.
19. van Heeswijk RP, Hoetelmans RM, Meenhorst PL, Mulder JW, Beijnen JH. Rapid determination of nevirapine in human plasma by ion-pair reversed-phase high-performance liquid chromatography with ultraviolet detection. J Chromatogr B Biomed Sci Appl 1998, 713(2):395-399. 10.1016/S0378-4347(98)00217-5, 9746255.
20. Dibley MJ, Staehling N, Nieburg P, Trowbridge FL. Interpretation of Z-score anthropometric indicators derived from the international growth reference. Am J Clin Nutr 1987, 46(5):749-762.
21. Dibley MJ, Goldsby JB, Staehling NW, Trowbridge FL. Development of normalized curves for the international growth reference: historical and technical considerations. Am J Clin Nutr 1987, 46(5):736-748.
22. World Health Organization Working Group Use and interpretation of anthropometric indicators of nutritional status. Bull World Health Organ 1986, 64(6):929-941. 2490974, 3493862, World Health Organization Working Group.
23. Taburet AM, Garrafo R, Goujard C, Molina M, Peytavin G, Treluyer JM. [Pharmacologie des Antirétroviraux: Indications des dosages plasmatiques des antirétroviraux]. Prise en charge médicale des personnes infectées par le VIH. Rapport 2006 2006, 171-184. Paris, Flammarion SA, Direction Générale de la Sante, ANRS.
24. World Health Organization Switching an ARV Regimen in Infants and Children: Treatment Failure. Antiretroviral therapy of HIV infection in infants and children in resource-limited settings: towards universal access. Recommendations for a public health approach 2006, 44-49. Geneva, Switzerland, World Health Organization.
25. Fassinou P, Elenga N, Rouet F, Laguide R, Kouakoussui KA, Timite M, Blanche S, Msellati P. Highly active antiretroviral therapies among HIV-1-infected children in Abidjan, Cote d'Ivoire. AIDS 2004, 18(14):1905-1913. 10.1097/00002030-200409240-00006, 15353976.
26. Chaix ML, Rouet F, Kouakoussui KA, Laguide R, Fassinou P, Montcho C, Blanche S, Rouzioux C, Msellati P. Genotypic human immunodeficiency virus type 1 drug resistance in highly active antiretroviral therapy-treated children in Abidjan, Cote d'Ivoire. Pediatr Infect Dis J 2005, 24(12):1072-1076. 10.1097/01.inf.0000190413.88671.92, 16371868.
27. Rouet F, Fassinou P, Inwoley A, Anaky MF, Kouakoussui A, Rouzioux C, Blanche S, Msellati P, . ANRS 1244/1278 Programme Enfants Yopougon Long-term survival and immuno-virological response of African HIV-1-infected children to highly active antiretroviral therapy regimens. AIDS 2006, 20(18):2315-2319. 10.1097/QAD.0b013e328010943b, 17117017, ANRS 1244/1278 Programme Enfants Yopougon.
28. Sutcliffe CG, van Dijk JH, Bolton C, Persaud D, Moss WJ. Effectiveness of antiretroviral therapy among HIV-infected children in sub-Saharan Africa. Lancet Infect Dis 2008, 8(8):477-489. 10.1016/S1473-3099(08)70180-4, 18652994.
29. Dunn D. Short-term risk of disease progression in HIV-1-infected children receiving no antiretroviral therapy or zidovudine monotherapy: a meta-analysis. Lancet 2003, 362(9396):1605-1611.
30. Taha TE, Graham SM, Kumwenda NI, Broadhead RL, Hoover DR, Markakis D, van Der Hoever L, Liomba GN, Chiphangwi JD, Miotti PG. Morbidity among human immunodeficiency virus-1-infected and -uninfected African children. Pediatrics 2000, 106(6):E77. 10.1542/peds.106.6.e77, 11099620.
31. Spira R, Lepage P, Msellati P, Van De Perre P, Leroy V, Simonon A, Karita E, Dabis F. Natural history of human immunodeficiency virus type 1 infection in children: a five-year prospective study in Rwanda. Mother-to-Child HIV-1 Transmission Study Group. Pediatrics 1999, 104(5):e56. 10.1542/peds.104.5.e56, 10545582.
32. Dabis F, Elenga N, Meda N, Leroy V, Viho I, Manigart O, Dequae-Merchadou L, Msellati P, Sombie I, . DITRAME Study Group 18-Month mortality and perinatal exposure to zidovudine in West Africa. AIDS 2001, 15(6):771-779. 10.1097/00002030-200104130-00013, 11371692, DITRAME Study Group.
33. Verweel G, van Rossum AM, Hartwig NG, Wolfs TF, Scherpbier HJ, de GR. Treatment with highly active antiretroviral therapy in human immunodeficiency virus type 1-infected children is associated with a sustained effect on growth. Pediatrics 2002, 109(2):E25. 10.1542/peds.109.2.e25, 11826235.
34. Janssens B, Raleigh B, Soeung S, Akao K, Te V, Gupta J, Vun MC, Ford N, Nouhin J, Nerrienet E. Effectiveness of highly active antiretroviral therapy in HIV-positive children: evaluation at 12 months in a routine programme in Cambodia. Pediatrics 2007, 120(5):2006-3503.
35. Puthanakit T, Aurpibul L, Oberdorfer P, Akarathum N, Kanjananit S, Wannarit P, Sirisanthana T, Sirisanthana V. Hospitalization and mortality among HIV-infected children after receiving highly active antiretroviral therapy. Clin Infect Dis 2007, 44(4):599-604. 10.1086/510489, 1924532, 17243067.
36. Violari A, Cotton MF, Gibb DM, Babiker AG, Steyn J, Madhi SA, Jean-Philippe P, McIntyre JA, . CHER Study Team Early antiretroviral therapy and mortality among HIV-infected infants. N Engl J Med 2008, 359(21):2233-2244. 10.1056/NEJMoa0800971, 2950021, 19020325, CHER Study Team.
37. O'Brien DP, Sauvageot D, Zachariah R, Humblet P. In resource-limited settings good early outcomes can be achieved in children using adult fixed-dose combination antiretroviral therapy. AIDS 2006, 20(15):1955-1960. 10.1097/01.aids.0000247117.66585.ce, 16988517.
38. van Rossum AM, Fraaij PL, de GR. Efficacy of highly active antiretroviral therapy in HIV-1 infected children. Lancet Infect Dis 2002, 2(2):93-102. 10.1016/S1473-3099(02)00183-4, 11901656.
39. Patel K, Hernan MA, Williams PL, Seeger JD, McIntosh K, Dyke RB, Seage GR, . Pediatric AIDS Clinical Trials Group 219/219 Study Team Long-term effects of highly active antiretroviral therapy on CD4+ cell evolution among children and adolescents infected with HIV: 5 years and counting. Clin Infect Dis 2008, 46(11):1751-1760. 10.1086/587900, 3154876, 18426371, Pediatric AIDS Clinical Trials Group 219/219 Study Team.
40. Kamya MR, Mayanja-Kizza H, Kambugu A, Bakeera-Kitaka S, Semitala F, Mwebaze-Songa P, Castelnuovo B, Schaefer P, Spacek LA, Gasasira AF, Katabira E, Colebunders R, Quinn TC, Ronald A, Thomas DL, Kekitiinwa A, . Academic Alliance for AIDS Care and Prevention in Africa Predictors of long-term viral failure among ugandan children and adults treated with antiretroviral therapy. J Acquir Immune Defic Syndr 2007, 46(2):187-193. 10.1097/QAI.0b013e31814278c0, 17693883, Academic Alliance for AIDS Care and Prevention in Africa.
41. Adje-Toure C, Hanson DL, Talla-Nzussouo N, Borget MY, Kouadio LY, Tossou O, Fassinou P, Bissagnene E, Kadio A, Nolan ML, Nkengasong JN. Virologic and immunologic response to antiretroviral therapy and predictors of HIV type 1 drug resistance in children receiving treatment in Abidjan, Cote d'Ivoire. AIDS Res Hum Retroviruses 2008, 24(7):911-917. 10.1089/aid.2007.0264, 18593341.
42. Prendergast A, Mphatswe W, Tudor-Williams G, Rakgotho M, Pillay V, Thobakgale C, McCarthy N, Morris L, Walker BD, Goulder P. Early virological suppression with three-class antiretroviral therapy in HIV-infected African infants. AIDS 2008, 22(11):1333-1343. 10.1097/QAD.0b013e32830437df, 18580613.
43. Spector SA, Hsia K, Yong FH, Cabral S, Fenton T, Fletcher CV, McNamara J, Mofenson LM, Starr SE. Patterns of plasma human immunodeficiency virus type 1 RNA response to highly active antiretroviral therapy in infected children. J Infect Dis 2000, 182(6):1769-1773. 10.1086/317621, 11069252.
44. Starr SE, Fletcher CV, Spector SA, Yong FH, Fenton T, Brundage RC, Manion D, Ruiz N, Gersten M, Becker M, McNamaara J, Mofenson LM, Purdue L, Siminski S, Graham B, Kornhauser DM, Fiske W, Vincent C, Lischner HW, Dankner WM, Flynn PM. Combination therapy with efavirenz, nelfinavir, and nucleoside reverse-transcriptase inhibitors in children infected with human immunodeficiency virus type 1. Pediatric AIDS Clinical Trials Group 382 Team. N Engl J Med 1999, 341(25):1874-1881. 10.1056/NEJM199912163412502, 10601506.
45. Melvin AJ, Rodrigo AG, Mohan KM, Lewis PA, Manns-Arcuino L, Coombs RW, Mullins JI, Frenkel LM. HIV-1 dynamics in children. J Acquir Immune Defic Syndr Hum Retrovirol 1999, 20(5):468-473. 10.1097/00042560-199904150-00009, 10225229.
46. Funk MB, Linde R, Wintergerst U, Notheis G, Hoffmann F, Schuster T, Kornhuber B, Ahrens P, Kreuz W. Preliminary experiences with triple therapy including nelfinavir and two reverse transcriptase inhibitors in previously untreated HIV-infected children. AIDS 1999, 13(13):1653-1658. 10.1097/00002030-199909100-00008, 10509566.
47. Vreeman RC, Wiehe SE, Ayaya SO, Musick BS, Nyandiko WM. Association of antiretroviral and clinic adherence with orphan status among HIV-infected children in Western Kenya. J Acquir Immune Defic Syndr 2008, 49(2):163-170. 10.1097/QAI.0b013e318183a996, 18769353.
48. Vreeman RC, Wiehe SE, Pearce EC, Nyandiko WM. A systematic review of pediatric adherence to antiretroviral therapy in low- and middle-income countries. Pediatr Infect Dis J 2008, 27(8):686-691. 10.1097/INF.0b013e31816dd325, 18574439.
49. Puthanakit T, Oberdorfer A, Akarathum N, Kanjanavanit S, Wannarit P, Sirisanthana T, Sirisanthana V. Efficacy of highly active antiretroviral therapy in HIV-infected children participating in Thailand's National Access to Antiretroviral Program. Clin Infect Dis 2005, 41(1):100-107. 10.1086/430714, 15937769.
50. da Silveira VL, Drachler ML, Leite JC, Pinheiro CA. Characteristics of HIV antiretroviral regimen and treatment adherence. Braz J Infect Dis 2003, 7(3):194-201.
51. Arpadi SM, Cuff PA, Horlick M, Wang J, Kotler DP. Lipodystrophy in HIV-infected children is associated with high viral load and low CD4+ -lymphocyte count and CD4+ -lymphocyte percentage at baseline and use of protease inhibitors and stavudine. J Acquir Immune Defic Syndr 2001, 27(1):30-34.
52. Jaquet D, Levine M, Ortega-Rodriguez E, Faye A, Polak M, Vilmer E, Lévy-Marchal C. Clinical and metabolic presentation of the lipodystrophic syndrome in HIV-infected children. AIDS 2000, 14(14):2123-2128. 10.1097/00002030-200009290-00008, 11061653.