Prolonged viral shedding in pandemic influenza A(H1N1): Clinical significance and viral load analysis in hospitalized patients

Clinical Microbiology and Infection

Volumn 17, Issue 8, 2011, Pages 1160-1165

  Giannella, M ^a   Alonso, M ^a,b   de Viedma, D Garcia ^a,b   Roa, P Lopez ^a   Catalan P ^a,b   Padilla, B ^a   Munoz P ^a,b   Bouza, E ^a,b  

^a HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Pandemic 2009 influenza A(H1N1) virus; Prolonged viral shedding; Viral load

Indexed keywords

CORTICOSTEROID; HEMAGGLUTININ; OSELTAMIVIR; RIBONUCLEASE P;

2009 H1N1 INFLUENZA; ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; ARTIFICIAL VENTILATION; ASTHMA; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL TRIAL; CORTICOSTEROID THERAPY; FEMALE; GENETIC ANALYSIS; HOSPITAL PATIENT; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INTENSIVE CARE UNIT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MIXED INFECTION; MORTALITY; NOSE SMEAR; PRIORITY JOURNAL; PROSPECTIVE STUDY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEPTIC SHOCK; THROAT CULTURE; VIRAL CLEARANCE; VIRUS LOAD; VIRUS SHEDDING;

INFLUENZA A VIRUS;

EID: 79960660773     PISSN: 1198743X     EISSN: 14690691     Source Type: Journal    
DOI: 10.1111/j.1469-0691.2010.03399.x     Document Type: Article

References (17)

1. Hayden FG. Prevention and treatment of influenza in immunocompromised patients. Am J Med 1997; 102: 55-60.
2. Thompson WW, Shay DK, Weintraub E et al. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA 2003; 289: 179-186.
3. Thompson WW, Shay DK, Weintraub E et al. Influenza-associated hospitalizations in the United States. JAMA 2004; 292: 1333-1340.
4. Chowell G, Bertozzi SM, Colchero MA et al. Severe respiratory disease concurrent with the circulation of H1N1 influenza. N Engl J Med 2009; 361: 674-679.
5. Jamieson DJ, Honein MA, Rasmussen SA et al. H1N1 2009 influenza virus infection during pregnancy in the USA. Lancet 2009; 374: 451-458.
6. Lee N, Chan PK, Hui DS et al. Viral loads and duration of viral shedding in adult patients hospitalized with influenza. J Infect Dis 2009; 200: 492-500.
7. Ling LM, Chow AL, Lye DC et al. Effects of early oseltamivir therapy on viral shedding in 2009 pandemic influenza A (H1N1) virus infection. Clin Infect Dis 2010; 50: 963-969.
8. Li IW, Hung IF, To KK et al. The natural viral load profile of patients with pandemic 2009 influenza A(H1N1) and the effect of oseltamivir treatment. Chest 2010; 137: 759-768.
9. To KK, Hung IF, Li IW et al. Delayed clearance of viral load and marked cytokine activation in severe cases of pandemic H1N1 2009 influenza virus infection. Clin Infect Dis 2010; 50: 850-859.
10. Bernard GR, Artigas A, Brigham KL et al. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 1994; 149: 818-824.
11. Dellinger RP, Levy MM, Carlet JM et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008; 36: 296-327.
12. Novel influenza A (H1N1) virus infections among health-care personnel-United States, April-May 2009. MMWR 2009; 58: 641-645.
13. De Serres G, Rouleau I, Hamelin ME et al. Contagious period for pandemic (H1N1) 2009. Emerg Infect Dis 2010; 16: 783-788.
14. To KK, Chan KH, Li IW et al. Viral load in patients infected with pandemic H1N1 2009 influenza A virus. J Med Virol 2010; 82: 1-7.
15. Gooskens J, Jonges M, Claas EC, Meijer A, Kroes AC. Prolonged influenza virus infection during lymphocytopenia and frequent detection of drug-resistant viruses. J Infect Dis 2009; 199: 1435-1441.
16. Duchamp MB, Casalegno JS, Gillet Y et al. Pandemic A(H1N1)2009 influenza virus detection by real time RT-PCR: is viral quantification useful? Clin Microbiol Infect 2010; 16: 317-321.
17. Ngaosuwankul N, Noisumdaeng P, Komolsiri P et al. Influenza A viral loads in respiratory samples collected from patients infected with pandemic H1N1, seasonal H1N1 and H3N2 viruses. Virol J 2010; 7: 75.