Differential effects of estrogen and micronized progesterone or medroxyprogesterone acetate on cognition in postmenopausal women

Fertility and Sterility

Volumn 96, Issue 2, 2011, Pages 399-403

  Sherwin, Barbara B ^a   Grigorova, Miglena ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

cognition; estrogen; medroxyprogesterone acetate; micronized progesterone; mood; Postmenopause

Indexed keywords

CONJUGATED ESTROGEN; FOLLITROPIN; LUTEINIZING HORMONE; MEDROXYPROGESTERONE ACETATE; MICRONIZED PROGESTERONE; PLACEBO; PROGESTERONE; SEX HORMONE; UNCLASSIFIED DRUG;

ADULT; ADVERTIZING; ARTICLE; BECK DEPRESSION INVENTORY; COGNITION; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; FOLLITROPIN BLOOD LEVEL; HORMONE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; LONG TERM MEMORY; LUTEINIZING HORMONE BLOOD LEVEL; MENTAL FUNCTION; MOOD; NEUROPSYCHOLOGICAL TEST; NORMAL HUMAN; POSTMENOPAUSE; PRIORITY JOURNAL; PUBLICATION; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SCREENING; SEX HORMONE DETERMINATION; SPATIAL MEMORY; TREATMENT OUTCOME; UNIVERSITY HOSPITAL; VERBAL MEMORY; VISUAL MEMORY; VISUAL SPATIAL SEQUENCING; WORKING MEMORY;

AFFECT; ANALYSIS OF VARIANCE; COGNITION; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; ESTROGEN REPLACEMENT THERAPY; ESTROGENS, CONJUGATED (USP); FEMALE; HOSPITALS, UNIVERSITY; HUMANS; MEDROXYPROGESTERONE ACETATE; MEMORY; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; POSTMENOPAUSE; PROGESTERONE; QUEBEC; TIME FACTORS;

EID: 79960652920     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2011.05.079     Document Type: Article

References (21)

1. B.B. Sherwin, and J.F. Henry Brain aging modulates the neuroprotective effect of estrogen on selective aspects of cognition in women: a critical review Front Neuroendocrinol 29 2008 88 113
2. S.A. Shumaker, C. Legault, L. Kuller, S. Rapp, L. Thal, and D.S. Lane Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women J Am Med Assoc 291 2004 2947 2958 (Pubitemid 38802684)
3. M.A. Espeland, S.R. Rapp, S.A. Shumaker, J.E. Manson, B.B. Sherwin, and J. Hsia Conjugated equine estrogens and global cognitive function in postmenopausal women JAMA 291 2004 2959 2968 (Pubitemid 38802685)
4. M.M. Rice, A. Borenstein-Graves, S.M. McCurry, L.E. Gibbons, J.D. Bowen, and W.C. McCormick Postmenopausal estrogen and estrogen-progestin use and 2-year rate of cognitive change in a cohort of older Japanese American women Arch Int Med 160 2000 1641 1649 (Pubitemid 30367903)
5. S.M. Resnick, P.M. Maki, S.R. Rapp, M.A. Espeland, R. Brunner, and L.H. Coker Effects of combination estrogen plus progestin hormone treatment on cognition and affect J Clin Endocrinol Metab 91 2006 1802 1810
6. M. Schumacher, R. Guennoun, A. Ghoumari, C. Massad, R. Robert, and M. El-Etr Novel perspectives for progesterone in hormone replacement therapy, with special reference to the nervous system Endocrine Rev 28 2007 387 439 (Pubitemid 46984826)
7. A.T. Beck, and R.A. Steer Manual for the Beck Depression Inventory 1987 The Psychological Corporation San Antonio, TX
8. B.B. Sherwin The impact of different doses of estrogen and progestin on mood and sexual behaviour in postmenopausal women J Clin Endocrinol Metab 72 1991 336 343 (Pubitemid 21921696)
9. D.A. Wechsler Wechsler Memory Scale-Revised manual 1987 The Psychological Corporation San Antonio, TX
10. S.G. Vandenberg, and A.R. Kuse Mental rotations, a group test of three-dimensional spatial visualization Percept Mot Skills 47 1978 599 604 (Pubitemid 9057344)
11. B.B. Sherwin Estrogen and/or androgen replacement therapy and cognitive functioning in surgically menopausal women Psychoneuroendocrinol 13 1988 345 357
12. S.M. Phillips, and B.B. Sherwin Effects of estrogen on memory function in surgically menopausal women Psychoneuroendocrinology 17 1992 485 495 (Pubitemid 23015018)
13. O.T. Wolf, A.B. Heinrich, B. Hanstein, and C. Kirschbaum Estradiol or estradiol/progesterone treatment in older women: no strong effects on cognition Neurobiol Aging 26 2005 1029 1033 (Pubitemid 40312667)
14. J.S. Janowsky, and B. Chavez Sex steroids modify working memory J Cog Neurosci 12 2000 407 414 (Pubitemid 30410281)
15. A.D. Baddeley Working memory 1986 Oxford University Press New York
16. T.A. Salthouse Mediation of adult age differences in cognition by reduction in working memory and speed of processing Psychol Sci 2 1991 179 183
17. C. Guerra-Araiza, O. Villamar-Cruz, A. Gonzales-Arenas, R. Chavira, and I. Camacho-Arroyo Changes in progesterone receptor isoforms content in the rat brain during the oestrous cycle and after oestradiol and progesterone treatments J Neuroendocrinol 15 2003 984 990 (Pubitemid 37193016)
18. J. Nilsen, and R.D. Brinton Impact of progestins on estrogen-induced neuroprotection: synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate Endocrine Rev 143 2002 205 212 (Pubitemid 34056421)
19. S. Solis-Ortiz, M.A. Guevara, and M. Corsi-Cabrera Performance in a test demanding prefrontal functions is favored by early luteal phase progesterone: an electroencephalographic study Psychoneuroendocrinology 29 2004 1047 1057 (Pubitemid 38833532)
20. B.B. Sherwin, and M.M. Gelfand Sex steroids and affect in the surgical menopause: a double-blind cross-over study Psychoneuroendocrinology 10 1985 325 335 (Pubitemid 16237741)
21. J.A. Cummings, and L. Brizendine Comparison of physical and emotional side effects of progesterone or medroxyprogesterone acetate in early postmenopausal women Menopause 9 2002 253 263 (Pubitemid 34743450)