Concerns about dextromethorphan as a potential rapid-acting antidepressant

Medical Hypotheses

Volumn 77, Issue 2, 2011, Pages 309-310

  Zhou, Zhiqiang ^a   Wu, Jing ^a   Yang, Chun ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DEXTROMETHORPHAN; KETAMINE; MAMMALIAN TARGET OF RAPAMYCIN;

DRUG EFFECT; HUMAN; LETTER; MONOAMINERGIC SYSTEM;

ANIMALS; ANTIDEPRESSIVE AGENTS; DEPRESSIVE DISORDER, MAJOR; DEXTROMETHORPHAN; EXCITATORY AMINO ACID ANTAGONISTS; HUMANS;

EID: 79960650255     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2011.05.013     Document Type: Letter

References (4)

1. Lauterbach E.C. Dextromethorphan as a potential rapid-acting antidepressant. Med Hypotheses 2011.
2. Machado-Vieira R., Salvadore G., Diazgranados N., et al. Ketamine and the next generation of antidepressants with a rapid onset of action. Pharmacol Ther 2009, 123:143-150.
3. Nishimura M., Sato K., Okada T., et al. Ketamine inhibits monoamine transporters expressed in human embryonic kidney 293 cells. Anesthesiology 1998, 88:768-774.
4. Li N., Lee B., Liu R.J., et al. MTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science 2010, 329:959-964.