Polymorphisms C677T and A1298C in the MTHFR gene in Mexican patients with rheumatoid arthritis treated with methotrexate: Implication with elevation of transaminases

Pharmacogenomics Journal

Volumn 11, Issue 4, 2011, Pages 287-291

  Mena, J P ^a   Salazar Paramo M ^b   Gonzalez Lopez L ^c   Gamez Nava J I ^b,c   Sandoval Ramirez, L ^d   Sanchez J D ^c   Figuera, L E ^d   Muoz Valle F J ^e   Vazquez Del Mercado, M ^e   Davalos I P ^a,d  

^a Instituto de Genética Humana   (Mexico)

^b HOSPITAL DE ESPECIALIDADES   (Mexico)

^c INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^d CENTRO DE INVESTIGACIÓN BIOMÉDICA DE OCCIDENTE   (Mexico)

^e CUCS   (Mexico)

Author keywords

methotrexate; MTHFR; pharmacogenetics; rheumatoid arthritis; transaminases

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; METHOTREXATE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; GENE; GENE FREQUENCY; GENE IDENTIFICATION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HETEROZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MTHFR GENE; PHARMACOGENETICS; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS;

ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; GENE FREQUENCY; GENOTYPE; HUMANS; INDIVIDUALIZED MEDICINE; METHOTREXATE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MEXICO; ODDS RATIO; PHARMACOGENETICS; PHENOTYPE; POLYMORPHISM, GENETIC; RISK ASSESSMENT; RISK FACTORS; TRANSAMINASES; TREATMENT OUTCOME; UP-REGULATION;

EID: 79960646716     PISSN: 1470269X     EISSN: 14731150     Source Type: Journal    
DOI: 10.1038/tpj.2010.32     Document Type: Article

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