Signal peptide mutations in RANK prevent downstream activation of NF-κB

Journal of Bone and Mineral Research

Volumn 26, Issue 8, 2011, Pages 1926-1938

  Crockett, Julie C ^a   Mellis, David J ^a   Shennan, Kathleen I J ^a   Duthie, Angela ^a   Greenhorn, John ^a   Wilkinson, Debbie I ^a   Ralston, Stuart H ^b   Helfrich, Miep H ^a   Rogers, Michael J ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

early onset Paget's disease; expansile skeletal hyperphosphatasia; familial expansile osteolysis; NF B; osteoclast; RANK

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; SIGNAL PEPTIDE;

ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; DOWNSTREAM PROCESSING; GENE; GENE DUPLICATION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; GOLGI COMPLEX; HUMAN; HUMAN CELL; OSTEOCLAST; OSTEOLYSIS; PROTEIN CLEAVAGE; PROTEIN LOCALIZATION; PROTEIN PROCESSING; RANK GENE; SIGNAL TRANSDUCTION; SMOOTH ENDOPLASMIC RETICULUM;

BASE SEQUENCE; CELL LINE; DNA NUCLEOTIDYLTRANSFERASES; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; MUTANT PROTEINS; MUTATION; NF-KAPPA B; OSTEOCLASTS; PROTEIN SORTING SIGNALS; PROTEIN TRANSPORT; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; REPRODUCIBILITY OF RESULTS; SUBCELLULAR FRACTIONS; TRANSFECTION;

EID: 79960633612     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.399     Document Type: Article

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