An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus

EMBO Journal

Volumn 30, Issue 14, 2011, Pages 2908-2919

  Etherton, Mark R ^a   Tabuchi, Katsuhiko ^a,b   Sharma, Manu ^a   Ko, Jaewon ^a   Südhof, Thomas C ^a,c  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

^c STANFORD UNIVERSITY   (United States)

Author keywords

Autism; neurexin; neuroligin; synaptic transmission; synaptogenesis

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; AMPA RECEPTOR; ARGININE; MEMBRANE PROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROLIGIN 3; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTISM; CONTROLLED STUDY; CYTOPLASM; HIPPOCAMPUS; HOMOLOGOUS RECOMBINATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MORPHOLOGY; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NEUROTRANSMITTER RELEASE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SYNAPSE; SYNAPTIC TRANSMISSION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; AUTISTIC DISORDER; CARRIER PROTEINS; CELL ADHESION MOLECULES, NEURONAL; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; CYTOPLASM; ELECTROPHYSIOLOGY; FEMALE; HIPPOCAMPUS; HUMANS; MALE; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; NEURONS; POINT MUTATION; RECEPTORS, AMPA; RECOMBINATION, GENETIC; SEQUENCE HOMOLOGY, AMINO ACID; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 79960627779     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2011.182     Document Type: Article

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