Preemptive plasmapheresis and recurrence of focal segmental glomerulosclerosis in pediatric renal transplantation

Pediatric Transplantation

Volumn 15, Issue 5, 2011, Pages 495-501

  Gonzalez, Elsa ^a   Ettenger, Robert ^a   Rianthavorn, Pornpimol ^a   Tsai, Eileen ^a   Malekzadeh, Mohammed ^a  

^a MATTEL CHILDREN S HOSPITAL   (United States)

Author keywords

focal segmental glomerulosclerosis; plasmapheresis; recurrence post transplantation

Indexed keywords

CORTICOSTEROID; CYCLOSPORIN A; DACLIZUMAB; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PODOCIN; SERUM ALBUMIN; TACROLIMUS; THYMOCYTE ANTIBODY;

ARTICLE; CHILD; CLINICAL ARTICLE; DRUG MEGADOSE; FEMALE; FOCAL GLOMERULOSCLEROSIS; GRAFT FAILURE; HUMAN; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; MALE; MUTATIONAL ANALYSIS; OUTCOME ASSESSMENT; PEDIATRIC SURGERY; PLASMAPHERESIS; PRESCHOOL CHILD; PROTEINURIA; RECURRENT DISEASE; RISK FACTOR; TREATMENT RESPONSE;

ADOLESCENT; BIOPSY; CHILD; FEMALE; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; GRAFT SURVIVAL; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; MALE; PLASMAPHERESIS; RECURRENCE; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 79960616980     PISSN: 13973142     EISSN: 13993046     Source Type: Journal    
DOI: 10.1111/j.1399-3046.2011.01478.x     Document Type: Article

References (47)

1. Dall'amico R, Ghiggeri G, Carraro M, et al., Prediction and treatment of recurrent focal segmental glomerulosclerosis after renal transplantation in children. Am J Kidney Dis 1999: 34: 1048-1055.
2. Cameron JS,. Recurrent renal disease after renal transplantation. Curr Opin Nephrol Hypertens 1994: 3: 602-607.
3. Kashtan CE, Mcenery PT, Tejani A, Stablein DM,. Renal allograft survival according to primary diagnosis: A report of the North American Pediatric Renal Transplant Cooperative Study. Pediatr Nephrol 1995: 9: 679-684. (Pubitemid 26003665)
4. Kim EM, Striegel J, Kim Y, Matas AJ, Najarian JS, Mauer SM,. Recurrence of steroid-resistant nephrotic syndrome in kidney transplants is associated with increased acute renal failure and acute rejection. Kidney Int 1994: 45: 1440-1445. (Pubitemid 24135032)
5. Baum MA,. Outcomes after renal transplantation for FSGS in children. Pediatr Transplant 2004: 8: 329-333. (Pubitemid 39062113)
6. Hubsch H, Montane B, Abitbol C, et al., Recurrent focal glomerulosclerosis in pediatric renal allografts: The Miami experience. Pediatr Nephrol 2005: 20: 210-216. (Pubitemid 40174037)
7. Mahesh S, Del Rio M, Feuerstein D, et al., Demographics and response to therapeutic plasma exchange in pediatric renal transplantation for focal glomerulosclerosis: A single center experience. Pediatr Transplant 2008: 12: 682-688.
8. Rizzoni G, Ehrich JH, Brunner FP, et al., Combined report on regular dialysis and transplantation of children in Europe, 1990. Nephrol Dial Transplant 1991: 6 (Suppl 4): 31-42.
9. Fine RN,. Recurrence of nephrotic syndrome/focal segmental glomerulosclerosis following renal transplantation in children. Pediatr Nephrol 2007: 22: 496-502. (Pubitemid 46332326)
10. Vincenti F, Ghiggeri GM,. New insights into the pathogenesis and the therapy of recurrent focal glomerulosclerosis. Am J Transplant 2005: 5: 1179-1185. (Pubitemid 40839405)
11. Baqi N, Tejani A,. Recurrence of the original disease in pediatric renal transplantation. J Nephrol 1997: 10: 85-92. (Pubitemid 27238901)
12. Senggutuvan P, Cameron JS, Hartley RB, et al., Recurrence of focal segmental glomerulosclerosis in transplanted kidneys: Analysis of incidence and risk factors in 59 allografts. Pediatr Nephrol 1990: 4: 21-28. (Pubitemid 20057505)
13. Cameron JS, Senguttuvan P, Hartley B, et al., Focal segmental glomerulosclerosis in fifty-nine renal allografts from a single centre; analysis of risk factors for recurrence. Transplant Proc 1989: 21: 2117-2118. (Pubitemid 19131156)
14. Winn MP, Alkhunaizi AM, Bennett WM, et al., Focal segmental glomerulosclerosis: A need for caution in live-related renal transplantation. Am J Kidney Dis 1999: 33: 970-974. (Pubitemid 29214699)
15. Savin VJ, Sharma R, Sharma M, et al., Circulating factor associated with increased glomerular permeability to albumin in recurrent focal segmental glomerulosclerosis. N Engl J Med 1996: 334: 878-883. (Pubitemid 26107345)
16. Savin VJ, Sharma R, Lovell HB, Welling DJ,. Measurement of albumin reflection coefficient with isolated rat glomeruli. J Am Soc Nephrol 1992: 3: 1260-1269.
17. Coward RJ, Foster RR, Patton D, et al., Nephrotic plasma alters slit diaphragm-dependent signaling and translocates nephrin, podocin, and CD2 associated protein in cultured human podocytes. J Am Soc Nephrol 2005: 16: 629-637. (Pubitemid 41725099)
18. Cochat P, Kassir A, Colon S, et al., Recurrent nephrotic syndrome after transplantation: Early treatment with plasmaphaeresis and cyclophosphamide. Pediatr Nephrol 1993: 7: 50-54. (Pubitemid 23045337)
19. Cochat P, Schell M, Ranchin B, Boueva A, Said MH,. Management of recurrent nephrotic syndrome after kidney transplantation in children. Clin Nephrol 1996: 46: 17-20. (Pubitemid 26237702)
20. Artero ML, Sharma R, Savin VJ, Vincenti F,. Plasmapheresis reduces proteinuria and serum capacity to injure glomeruli in patients with recurrent focal glomerulosclerosis. Am J Kidney Dis 1994: 23: 574-581. (Pubitemid 24109121)
21. Garcia CD, Bittencourt VB, Tumelero A, Antonello JS, Malheiros D, Garcia VD,. Plasmapheresis for recurrent posttransplant focal segmental glomerulosclerosis. Transplant Proc 2006: 38: 1904-1905. (Pubitemid 44190082)
22. Gohh RY, Yango AF, Morrissey PE, et al., Preemptive plasmapheresis and recurrence of FSGS in high-risk renal transplant recipients. Am J Transplant 2005: 5: 2907-2912. (Pubitemid 43923951)
23. Haffner K, Zimmerhackl LB, Von Schnakenburg C, Brandis M, Pohl M,. Complete remission of post-transplant FSGS recurrence by long-term plasmapheresis. Pediatr Nephrol 2005: 20: 994-997. (Pubitemid 40909275)
24. Ohta T, Kawaguchi H, Hattori M, et al., Effect of pre-and postoperative plasmapheresis on posttransplant recurrence of focal segmental glomerulosclerosis in children. Transplantation 2001: 71: 628-633. (Pubitemid 32268063)
25. Dantal J, Bigot E, Bogers W, et al., Effect of plasma protein adsorption on protein excretion in kidney-transplant recipients with recurrent nephrotic syndrome. N Engl J Med 1994: 330: 7-14.
26. Deegens JK, Andresdottir MB, Croockewit S, Wetzels JF,. Plasma exchange improves graft survival in patients with recurrent focal glomerulosclerosis after renal transplant. Transpl Int 2004: 17: 151-157. (Pubitemid 38660692)
27. Bhakta N, Marik J, Malekzadeh M, Gjertson D, Ettenger R,. Can pediatric steroid-free renal transplantation improve growth and metabolic complications? Pediatr Transplant 2008: 12: 854-861.
28. Sharma M, Sharma R, Reddy SR, Mccarthy ET, Savin VJ,. Proteinuria after injection of human focal segmental glomerulosclerosis factor. Transplantation 2002: 73: 366-372. (Pubitemid 34174285)
29. Zimmerman SW,. Increased urinary protein excretion in the rat produced by serum from a patient with recurrent focal glomerular sclerosis after renal transplantation. Clin Nephrol 1984: 22: 32-38. (Pubitemid 14089429)
30. Artero M, Biava C, Amend W, Tomlanovich S, Vincenti F,. Recurrent focal glomerulosclerosis: Natural history and response to therapy. Am J Med 1992: 92: 375-383.
31. Pirson Y, Squifflet JP, Marbaix E, Alexandre GP, Van Ypersele De Strihou C,. Recurrence of focal glomerulosclerosis despite cyclosporin treatment after renal transplantation. Br Med J (Clin Res Ed) 1986: 292: 1336. (Pubitemid 16110015)
32. Vincenti F, Biava C, Tomlanovitch S, et al., Inability of cyclosporine to completely prevent the recurrence of focal glomerulosclerosis after kidney transplantation. Transplantation 1989: 47: 595-598. (Pubitemid 19110912)
33. Raafat RH, Kalia A, Travis LB, Diven SC,. High-dose oral cyclosporin therapy for recurrent focal segmental glomerulosclerosis in children. Am J Kidney Dis 2004: 44: 50-56. (Pubitemid 38880926)
34. Ingulli E, Tejani A, Butt KM, et al., High-dose cyclosporine therapy in recurrent nephrotic syndrome following renal transplantation. Transplantation 1990: 49: 219-221. (Pubitemid 20051622)
35. Salomon R, Gagnadoux MF, Niaudet P,. Intravenous cyclosporine therapy in recurrent nephrotic syndrome after renal transplantation in children. Transplantation 2003: 75: 810-814. (Pubitemid 36373453)
36. Sener A, Bella AJ, Nguan C, Luke PP, House AA,. Focal segmental glomerular sclerosis in renal transplant recipients: Predicting early disease recurrence may prolong allograft function. Clin Transplant 2009: 23: 96-100.
37. Odorico JS, Knechtle SJ, Rayhill SC, et al., The influence of native nephrectomy on the incidence of recurrent disease following renal transplantation for primary glomerulonephritis. Transplantation 1996: 61: 228-234. (Pubitemid 26044536)
38. Jungraithmayr TC, Bulla M, Dippell J, et al., Primary focal segmental glomerulosclerosis-long-term outcome after pediatric renal transplantation. Pediatr Transplant 2005: 9: 226-231. (Pubitemid 40476853)
39. Weber S, Tonshoff B,. Recurrence of focal-segmental glomerulosclerosis in children after renal transplantation: Clinical and genetic aspects. Transplantation 2005: 80: S128-S134. (Pubitemid 41552923)
40. Baum MA, Stablein DM, Panzarino VM, Tejani A, Harmon WE, Alexander SR,. Loss of living donor renal allograft survival advantage in children with focal segmental glomerulosclerosis. Kidney Int 2001: 59: 328-333. (Pubitemid 32055241)
41. NAPRTCS. Annual Report. In: Available at:; (accessed February 02, 2011) 2008.
42. Schachter AD, Harmon WE,. Single-center analysis of early recurrence of nephrotic syndrome following renal transplantation in children. Pediatr Transplant 2001: 5: 406-409. (Pubitemid 33095203)
43. Abbott KC, Sawyers ES, Oliver JD III, et al., Graft loss due to recurrent focal segmental glomerulosclerosis in renal transplant recipients in the United States. Am J Kidney Dis 2001: 37: 366-373. (Pubitemid 32116030)
44. Bertelli R, Ginevri F, Caridi G, et al., Recurrence of focal segmental glomerulosclerosis after renal transplantation in patients with mutations of podocin. Am J Kidney Dis 2003: 41: 1314-1321. (Pubitemid 36637988)
45. Caridi G, Perfumo F, Ghiggeri GM,. NPHS2 (Podocin) mutations in nephrotic syndrome. Clinical spectrum and fine mechanisms. Pediatr Res 2005: 57: 54R-61R. (Pubitemid 40593246)
46. Weber S, Gribouval O, Esquivel EL, et al., NPHS2 mutation analysis shows genetic heterogeneity of steroid-resistant nephrotic syndrome and low post-transplant recurrence. Kidney Int 2004: 66: 571-579. (Pubitemid 38981997)
47. Furue T, Hattori M, Tsukaguchi H, et al., Clinical features and mutational survey of NPHS2 (podocin) in Japanese children with focal segmental glomerulosclerosis who underwent renal transplantation. Pediatr Transplant 2008: 12: 341-346. (Pubitemid 351589438)