TLRs innate immunereceptors and Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) CIDR1α-driven human polyclonal B-cell activation

Acta Tropica

Volumn 119, Issue 2-3, 2011, Pages 144-150

  Simone, Olivia ^a,e   Bejarano, Maria Teresa ^b,c   Pierce, Susan K ^d   Antonaci, Salvatore ^a   Wahlgren, Mats ^c   Troye Blomberg, Marita ^e   Donati, Daria ^b  

^a UNIVERSITY OF BARI MEDICAL SCHOOL   (Italy)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^e STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

B cells; Malaria; Signal transduction; Toll like receptors (TLRs)

Indexed keywords

ADAPTOR PROTEIN; CD40 ANTIGEN; ERYTHROCYTE MEMBRANE PROTEIN 1; ERYTHROCYTE MEMBRANE PROTEIN 1 CYSTEINE RICH INTERDOMAIN REGION 1ALPHA; I KAPPA B ALPHA; IMIQUIMOD; LYMPHOCYTE MEMBRANE IMMUNOGLOBULIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCLONAL ANTIBODY; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTYROSINE; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN KINASE LYN; PROTEIN KINASE SYK; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 10; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

CELL ORGANELLE; IMMUNE SYSTEM; MALARIA; MEMBRANE; PROTEIN;

ARTICLE; B LYMPHOCYTE ACTIVATION; CELL SURFACE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; POLYCLONAL ACTIVATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION;

B-LYMPHOCYTES; HUMANS; LYMPHOCYTE ACTIVATION; MYELOID DIFFERENTIATION FACTOR 88; PLASMODIUM FALCIPARUM; PROTEIN BINDING; PROTOZOAN PROTEINS; RECEPTORS, ANTIGEN, B-CELL; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 10; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 9;

PLASMODIUM FALCIPARUM;

EID: 79960592524     PISSN: 0001706X     EISSN: 18736254     Source Type: Journal    
DOI: 10.1016/j.actatropica.2011.05.005     Document Type: Article

References (39)

1. Abele D.C., Tobie J.E., Hill G.J., Contacos P.G., Evans C.B. Alterations in serum proteins and 19S antibody production during the course of induced malaria infections in man. Am. J. Trop. Med. Hyg. 1965, 14:191-197.
2. Adu D., Williams D.G., Quakyi I.A., Voller A., Anim-Addo Y., Bruce-Tagoe A.A., Johnson G.D., Holborow E.J. Anti-ssDNA and antinuclear antibodies in human malaria. Clin. Exp. Immunol. 1982, 49:310-316.
3. Aggarwal B.B. Apoptosis and nuclear factor-kappa B: a tale of association and dissociation. Biochem. Pharmacol. 2000, 60:1033-1039.
4. Akira S., Takeda K. Toll-like receptor signaling. Nat. Rev. Immunol. 2004, 4:499-511.
5. Banic D.M., Viana-Martins F.S., De Souza J.M., Peixoto T.D., Daniel-Ribeiro C. Polyclonal B-lymphocyte stimulation in human malaria and its association with ongoing parasitemia. Am. J. Trop. Med. Hyg. 1991, 44:571-577.
6. Bates I., Bedu-Addo G. Chronic malaria and splenic lymphoma: clues to understanding lymphoma evolution. Leukemia 1997, 11:2162-2167.
7. Bekeredjian-Ding I.B., Wagner M., Hornung V., Giese T., Schnurr M., Endres S., Hartmann G. Plasmacytoid dendritic cells control TLR7 sensitivity of nave B cells via Type I IFN. J. Immunol. 2005, 174:4043-4050.
8. Bernasconi N.L., Onai N., Lanzavecchia A. A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in nave B cells and constitutive expression in memory B cells. Blood 2003, 101:4500-4504.
9. Bernasconi N., Traggiai E., Lanzavecchia A. Maintenance of serological memory by polyclonal activation of human memory B cells. Science 2002, 289:2199-2202.
10. Bourke E., Bosisio D., Golay J., Polentarutti N., Mantovani A. The Toll-like repertoire of human B lymphocytes: inducible and selective expression of TLR9 and TLR10 in normal and transformed cells. Blood 2002, 102:956-963.
11. Campbell K.S. Signal transduction from the B cell antigen-receptor. Curr. Opin. Immunol. 1999, 11:256-264.
12. Chaturvedi A., Pierce S.K. How location governs toll-like receptor signaling. Traffic 2009, 10:621-628.
13. Chaturvedi A., Dorward D., Pierce S.K. The B cell receptor governs the subcellular location of toll-like receptor 9 leading to hyperresponses to DNA-containing antigens. Immunity 2008, 28:799-809.
14. Chen Q., Barragan A., Fernandez V., Sundstrom A., Schichtherle M., Sahlen A., Carlson J., Datta S., Wahlgren M. Identification of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) as the rosetting ligand of the malaria parasite P. falciparum. J. Exp. Med. 1998, 187:15-23.
15. Chen Q., Heddini A., Barragan A., Fernandez V., Pearce S.F., Wahlgren M. The semiconserved head structure of Plasmodium falciparum erythrocyte membrane protein 1 mediates binding to multiple independent host receptors. J. Exp. Med. 2000, 192:1-10.
16. Christensen S.R., Kashgarian M., Alexopoulo L., Flavell R.A., Akira S., Shlomchik M.J. Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus. J. Exp. Med. 2005, 202:321-331.
17. Dal Porto J.M., Gauld S.B., Merrel K.T., Mills D., Pugh-Bernard A.E., Cambier J. B cell antigen receptor signaling. Mol. Immunol. 2004, 41:599-613.
18. Deane J.A., Pisitkun P., Barret R.S., Feigenbaum L., Town T., Ward J.M., Flavell R.A., Bolland S. Control of Toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation. Immunity 2007, 27:801-810.
19. Donati D., Mok B., Chene A., Xu H., Thangarajh M., Glas R., Chen Q., Wahlgren M., Bejarano M.T. Increased B cell survival and preferential activation of the memory compartment by a malaria polyclonal B cell activator. J. Immunol. 2006, 177:3035-3044.
20. Donati D., Zhang L.P., Chen Q., Chene A., Flick K., Nystrom M., Wahlgren M., Bejarano M.T. Identification of a polyclonal B-cell activator in Plasmodium falciparum. Infect. Immun. 2004, 72:5412-5418.
21. Flick K., Scholander C., Chen Q., Fernandez V., Pouvelle B., Gysin J., Wahlgren M. Role of nonimmune IgG bound to PfEMP1 in placental malaria. Science 2001, 293:2098-2100.
22. Greenwood B.M., Vick R.M. Evidence for a malaria mitogen in human malaria. Nature 1975, 257:592-594.
23. Grossman M., O'Reilly L.A., Gugasyan R., Strasse A., Adams J.M., Gerondakis S. The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression. EMBO J. 2000, 19:6351-6360.
24. Hasan U., Chaffois C., Gaillard C., Saulnier V., Merck E., Tancredi S., Guiet C., Briere F., Vlach J., Lebeque S., Trinchieri G., Bates E.E.M. Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88. J. Immunol. 2005, 174:2942-2950.
25. Hornung V., Rothenfusser S., Britsch S., Krug A., Jahrsdorfer B., Giese T., Endres S., Hartmann G. Quantitative expression of Toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J. Immunol. 2002, 168:4531-4537.
26. Jendholm J., Mörgelin M., Perez Vidakovics M.L.A., Carlsson M., Leffler H., Cardell L.O., Riesbeck K. Superantigen- and TLR-dependent activation of tonsillar B cells after receptor-mediated endocytosis. J. Immunol. 2009, 182:4713-4720.
27. Lanzavecchia A., Sallusto F. Toll-like receptors and innate immunity in B-cell activation and antibody responses. Curr. Opin. Immunol. 2007, 19:268-274.
28. Lau C.M., Broughton C., Tabor A.S., Akira S., Flavell R.A., Mamula M.J., Christensen S.R., Shlomchik M.J., Viglianti G.A., Rifkin I.R., Marshak-Rothstein A. RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J. Exp. Med. 2005, 202:1171-1177.
29. Leadbetter E.A., Rikfin I.R., Hohlbaum A.M., Baudette B.C., Shlomchik M.J., Marshak-Rothstein A. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 2002, 416:603-607.
30. McGregor I.A., Giles H.M., Walter J.H., Davies A.H. Effects of heavy and repeated malaria infections of Gambian infants and children. Br. Med. J. 1956, 2:686-691.
31. Pisitkun P., Deane J.A., Difilippantonio M.J., Tarasenko T., Satterthwaite A.B., Bolland S. Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication. Science 2006, 312:1669-1672.
32. Poeck H., Wagner M., Battiany J., Rothenfusser S., Wellisch D., Hornung V., Jahrsdorfer B., Giese T., Endres S., Hartmann G. Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help. Blood 2003, 103:3058-3064.
33. Reis e Sousa C. Dendritic cells in a mature age. Nat. Rev. Immunol. 2006, 6:476-483.
34. Ruprecht C.R., Lanzavecchia A. Toll-like receptor as a third signal required for activation of human nave B cells. Eur. J. Immunol. 2006, 36:810-816.
35. Su X.Z., Heatwole V.M., Wertheimer S.P., Guinet F., Herrfeldt J.A., Peterson D.S., Ravetch J.A., Wellems T.E. The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes. Cell 1995, 82:89-100.
36. Takeda K., Kaisho T., Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003, 21:335.
37. Tomai M.A., Imbertson L.M., Stanczak T.L., Tygrett L.T., Waldschmidt T.J. The immune response modifiers imiquimod and R-848 are potent activators of B lymphocytes. Cell. Immunol. 2000, 203:55-65.
38. Trinchieri G., Sher A. Cooperation of Toll-like receptor signals in innate immune defence. Nat. Rev. Immunol. 2007, 7:179-190.
39. Viglianti G.A., Lau C.M., Hanley T.M., Miko B.A., Shlomchik M.J., Marshak-Rothstein A. Activation of autoreactive B cells by CpG dsDNA. Immunity 2003, 19:837-847.