A retrospective study exploring the effects of intramuscular aripiprazole on QTc change in agitated medically ill patients

Journal of Clinical Psychopharmacology

Volumn 31, Issue 4, 2011, Pages 532-534

  Muzyk, Andrew J ^a   Rivelli, Sarah K ^b   Gagliardi, Jane P ^b   Revollo, Jane Y ^c   Jiang, Wei ^b  

^a CAMPBELL UNIVERSITY   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARIPIPRAZOLE;

AGITATION; HOSPITALIZATION; HUMAN; HYPOTENSION; INFORMATION PROCESSING; LETTER; LONG QT SYNDROME; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCHIZOPHRENIA; WILCOXON SIGNED RANKS TEST;

AGED; COHORT STUDIES; FEMALE; HEART RATE; HOSPITALIZATION; HUMANS; INJECTIONS, INTRAMUSCULAR; MALE; MIDDLE AGED; PIPERAZINES; PSYCHOMOTOR AGITATION; QUINOLONES; RETROSPECTIVE STUDIES;

EID: 79960575377     PISSN: 02710749     EISSN: 1533712X     Source Type: Journal    
DOI: 10.1097/JCP.0b013e318221e63b     Document Type: Letter

References (15)

1. Ely EW, Gautam S, Margolin R, et al. The impact of delirium in the intensive care unit on hospital length of stay. Intensive Care Med. 2001;27(12):1892-1900. (Pubitemid 33145075)
2. Young J, Inouye S. Delirium in older people. BMJ. 2007;334(7598):842-846. (Pubitemid 46706931)
3. Practice guideline for the treatment of patients with delirium. American Psychiatric Association. Am J Psychiatry. 1999;156:1-20.
4. Jacobi J, Fraser GL, Coursin DB, et al. Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult. Crit Care Med. 2002;30:119-141. (Pubitemid 34112188)
5. Battaglia J. Pharmacological management of acute agitation. Drugs. 2005;65(9): 1207-1222. (Pubitemid 41032047)
6. Citrome L. Interventions for the treatment of acute agitation. CNS Spectr. 2007;12(suppl 11)8-12.
7. Haloperidol [package insert]. Princeton, NJ: Sandoz Inc; 2008.
8. Abilify Intramuscular [package insert]. Tokyo, Japan: Otsuka Pharmaceutical Company; 2009.
9. Vieweg WV. Mechanisms and risks of electrocardiographic QT interval prolongation when using antipsychotic drugs. J Clin Psychiatry. 2002;63(suppl 9):18-24.
10. Arizona Center for Education and Research on Therapeutics. Available at: http://www.azcert.org/. Accessed October 1, 2010.
11. Metzger E, Friedman R. Prolongation of the corrected QT and torsades de pointes cardiac arrhythmia associated with intravenous haloperidol in the medically ill. J Clin Psychopharmacol. 1993;13(2):128-132. (Pubitemid 23087229)
12. Andrezina R, Josiassen RC, Marcus RN, et al. Intramuscular aripiprazole for the treatment of acute agitation in patients with schizophrenia or schizoaffective disorder: a double-blind, placebo-controlled comparison with intramuscular haloperidol. Psychopharmacology. 2006;188(3):281-292. (Pubitemid 44387456)
13. Tran-Johnson TK, Sack DA, Marcus RN, et al. Efficacy and safety of intramuscular aripiprazole in patients with acute agitation: a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry. 2007;68(1):111-119. (Pubitemid 46220132)
14. Zimbroff DL, Marcus RN, Manos G, et al. Management of acute agitation in patients with bipolar disorder: efficacy and safety of intramuscular aripiprazole. J Clin Psychopharmacol. 2007;27(2):171-176. (Pubitemid 46594934)
15. Straker DA, Shapiro PA, Muskin PR. Aripiprazole in the treatment of delirium. Psychosomatics. 2006;47(5): 385-391.