Heterotopic ossifications following implant surgery - Epidemiology, therapeutical approaches and current concepts

Seminars in Immunopathology

Volumn 33, Issue 3, 2011, Pages 273-286

  Zeckey, Christian ^a   Hildebrand, Frank ^a   Frink, Michael ^a   Krettek, Christian ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Acetabular fracture; Heterotopic ossification; Knee arthroplasty; Posttraumatic complications; Total hip arthroplasty

Indexed keywords

ACETYLSALICYLIC ACID; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; IBUPROFEN; INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO;

ACETABULUM FRACTURE; BONE NAIL; BONE RADIOGRAPHY; BONE SCINTISCANNING; CARDIOVASCULAR DISEASE; COMPUTER ASSISTED TOMOGRAPHY; DISEASE CLASSIFICATION; DRUG EFFECT; DRUG EFFICACY; EARLY DIAGNOSIS; ECHOGRAPHY; ELBOW; GASTROINTESTINAL HEMORRHAGE; HETEROTOPIC OSSIFICATION; HIP SURGERY; HUMAN; IMPLANTATION; INCIDENCE; INTRAMEDULLARY NAILING; NERVE PARALYSIS; OSTEOSYNTHESIS; PATHOPHYSIOLOGY; POSTOPERATIVE HEMORRHAGE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROPHYLAXIS; RADIATION RESPONSE; RANGE OF MOTION; RECURRENCE RISK; REVIEW; RISK FACTOR; TOTAL HIP PROSTHESIS; TOTAL KNEE REPLACEMENT; TREATMENT INDICATION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHEMOPREVENTION; HUMANS; JOINT PROSTHESIS; OSSIFICATION, HETEROTOPIC; RISK FACTORS;

EID: 79960565376     PISSN: 18632297     EISSN: 18632300     Source Type: Journal    
DOI: 10.1007/s00281-011-0240-5     Document Type: Review

References (105)

1. Sawyer JR, Myers MA, Rosier RN, Puzas JE (1991) Heterotopic ossification: clinical and cellular aspects. Calcif Tissue Int 49:208-215
2. Shore EM, Ahn J, Jan de Beur S, Li M, Xu M, Gardner RJ, Zasloff MA, Whyte MP, Levine MA, Kaplan FS (2002) Paternally inherited inactivating mutations of the GNAS1 gene in progressive osseous heteroplasia. N Engl J Med 346:99-106 (Pubitemid 34438900)
3. Reppe K, Tschernig T, Luhrmann A, van Laak V, Grote K, Zemlin MV, Gutbier B, Muller HC, Kursar M, Schutte H, Rosseau S, Pabst R, Suttorp NW, Witzenrath M (2008) Immunostimulation with macrophage-activating lipopeptide-2 increased survival in murine pneumonia. Am J Respir Cell Mol Biol 40(4):474-481
4. Garland DE (1988) Clinical observations on fractures and heterotopic ossification in the spinal cord and traumatic brain injured populations. Clin Orthop Relat Res 233:86-101
5. Citta-Pietrolungo TJ, Alexander MA, Steg NL (1992) Early detection of heterotopic ossification in young patients with traumatic brain injury. Arch Phys Med Rehabil 73:258-262
6. Roberts JB, Pankratz DG (1979) The surgical treatment of heterotopic ossification at the elbow following long-term coma. J Bone Joint Surg Am 61:760-763 (Pubitemid 9232035)
7. Lorber J (1953) Ectopic ossification in tuberculous meningitis. Arch Dis Child 28:98-103
8. Harris WH (1972) Clinical results using the Mueller-Charnley total hip prosthesis. Clin Orthop Relat Res 86:95-101
9. Chao ST, Lee SY, Borden LS, Joyce MJ, Krebs VE, Suh JH (2006) External beam radiation helps prevent heterotopic bone formation in patients with a history of heterotopic ossification. J Arthroplasty 21:731-736 (Pubitemid 44108562)
10. Arcq M (1973) Ectopic ossification: a complication after total hip replacement (author's transl). Arch Orthop Unfallchir 77:108-131
11. Brooker AF, Bowerman JW, Robinson RA, Riley LH Jr (1973) Ectopic ossification following total hip replacement. Incidence and a method of classification. J Bone Joint Surg Am 55:1629-1632
12. DeLee J, Ferrari A, Charnley J (1976) Ectopic bone formation following low friction arthroplasty of the hip. Clin Orthop Relat Res 121:53-59 (Pubitemid 8003192)
13. Petsatodis G, Antonarakos P, Chalidis B, Papadopoulos P, Christoforidis J, Pournaras J (2007) Surgically treated acetabular fractures via a single posterior approach with a follow-up of 2-10 years. Injury 38:334-343 (Pubitemid 46328916)
14. Giannoudis PV, Grotz MR, Papakostidis C, Dinopoulos H (2005) Operative treatment of displaced fractures of the acetabulum. A meta-analysis. J Bone Joint Surg Br 87:2-9
15. Ghalambor N, Matta JM, Bernstein L (1994) Heterotopic ossification following operative treatment of acetabular fracture. An analysis of risk factors. Clin Orthop Relat Res 305:96-105 (Pubitemid 24320986)
16. Daum WJ, Scarborough MT, Gordon W Jr, Uchida T (1992) Heterotopic ossification and other perioperative complications of acetabular fractures. J Orthop Trauma 6:427-432
17. Ahrengart L, Lindgren U (1993) Heterotopic bone after hip arthroplasty. Defining the patient at risk. Clin Orthop Relat Res 293:153-159 (Pubitemid 23242864)
18. Furia JP, Pellegrini VD Jr (1995) Heterotopic ossification following primary total knee arthroplasty. J Arthroplasty 10:413-419
19. Mikic ZD, Vukadinovic SM (1983) Late results in fractures of the radial head treated by excision. Clin Orthop Relat Res 181:220-228 (Pubitemid 14215225)
20. Rader CP, Barthel T, Haase M, Scheidler M, Eulert J (1997) Heterotopic ossification after total knee arthroplasty. 54/615 cases after 1-6 years' follow-up. Acta Orthop Scand 68:46-50 (Pubitemid 27084971)
21. Ellerin BE, Helfet D, Parikh S, Hotchkiss RN, Levin N, Nisce L, Nori D, Moni J (1999) Current therapy in the management of heterotopic ossification of the elbow: a review with case studies. Am J Phys Med Rehabil 78:259-271 (Pubitemid 29227173)
22. Chalmers J, Gray DH, Rush J (1975) Observations on the induction of bone in soft tissues. J Bone Joint Surg Br 57:36-45
23. Reddi AH (1995) Bone morphogenetic proteins, bone marrow stromal cells, and mesenchymal stem cells. Maureen Owen revisited. Clin Orthop Relat Res 313:115-119
24. Shafritz AB, Shore EM, Gannon FH, Zasloff MA, Taub R, Muenke M, Kaplan FS (1996) Overexpression of an osteogenic morphogen in fibrodysplasia ossificans progressiva. N Engl J Med 335:555-561 (Pubitemid 26272310)
25. Schurch B, Capaul M, Vallotton MB, Rossier AB (1997) Prostaglandin E2 measurements: their value in the early diagnosis of heterotopic ossification in spinal cord injury patients. Arch Phys Med Rehabil 78:687-691 (Pubitemid 27295111)
26. Iorio R, Healy WL (2002) Heterotopic ossification after hip and knee arthroplasty: risk factors, prevention, and treatment. J Am Acad Orthop Surg 10:409-416
27. Dejerne A, Ceiller A (1918) Para-osteo-arthropathies des paraplegiques par lesion medullaire: etude clinique et radiographique. Ann Med 5:497
28. Pape HC, Marsh S, Morley JR, Krettek C, Giannoudis PV (2004) Current concepts in the development of heterotopic ossification. J Bone Joint Surg Br 86:783-787 (Pubitemid 39173460)
29. Barrack RL, Brumfield CS, Rorabeck CH, Cleland D, Myers L (2002) Heterotopic ossification after revision total knee arthroplasty. Clin Orthop Relat Res 404:208-213 (Pubitemid 35351073)
30. Marks PH, Paley D, Kellam JF (1988) Heterotopic ossification around the hip with intramedullary nailing of the femur. J Trauma 28:1207-1213
31. Wlodarski KH (1991) Bone histogenesis mediated by nonosteogenic cells. Clin Orthop Relat Res 8-15.
32. Puzas JE, Evarts CM, Brand JS (1987) The stimulus for bone formation. Hip 25-38.
33. Pape HC, Lehmann U, van Griensven M, Gansslen A, von Glinski S, Krettek C (2001) Heterotopic ossifications in patients after severe blunt trauma with and without head trauma: incidence and patterns of distribution. J Orthop Trauma 15:229-237 (Pubitemid 32611309)
34. Hoffer MM, Brody G, Ferlic F (1978) Excision of heterotopic ossification about elbows in patients with thermal injury. J Trauma 18:667-670 (Pubitemid 9030191)
35. Ashton LA, Bruce W, Goldberg J, Walsh W (2000) Prevention of heterotopic bone formation in high risk patients post-total hip arthroplasty. J Orthop Surg (Hong Kong) 8:53-57 (Pubitemid 33077845)
36. Morrey BF, Adams RA, Cabanela ME (1984) Comparison of heterotopic bone after anterolateral, transtrochanteric, and posterior approaches for total hip arthroplasty. Clin Orthop Relat Res 188:160-167 (Pubitemid 14029168)
37. Purtill JJ, Eng K, Rothman RH, Hozack WJ (1996) Heterotopic ossification. Incidence in cemented versus cementless total hip arthroplasty. J Arthroplasty 11:58-63 (Pubitemid 26047996)
38. Gebuhr P, Sletgard J, Dalsgard J, Soelberg M, Keisu K, Hanninen A, Crawford M (1996) Heterotopic ossification after hip arthroplasty: a randomized double-blind multicenter study tenoxicam in 147 hips. Acta Orthop Scand 67:29-32
39. Ahrengart L (1991) Periarticular heterotopic ossification after total hip arthroplasty. Risk factors and consequences. Clin Orthop Relat Res 263:49-58
40. Ritter MA, Vaughan RB (1977) Ectopic ossification after total hip arthroplasty. Predisposing factors, frequency, and effect on results. J Bone Joint Surg Am 59:345-351 (Pubitemid 8088663)
41. Sundaram NA, Murphy JC (1986) Heterotopic bone formation following total hip arthroplasty in ankylosing spondylitis. Clin Orthop Relat Res 207:223-226
42. Dalury DF, Jiranek WA (2004) The incidence of heterotopic ossification after total knee arthroplasty. J Arthroplasty 19:447-452 (Pubitemid 38725926)
43. Toyoda T, Matsumoto H, Tsuji T, Kinouchi J, Fujikawa K (2003) Heterotopic ossification after total knee arthroplasty. J Arthroplasty 18:760-764 (Pubitemid 37176607)
44. Harwin SF, Stein AJ, Stern RE, Kulick RG (1993) Heterotopic ossification following primary total knee arthroplasty. J Arthroplasty 8:113-116 (Pubitemid 23112659)
45. Ahrengart L, Lindgren U (1989) Functional significance of heterotopic bone formation after total hip arthroplasty. J Arthroplasty 4:125-131
46. Zeckey C, Hildebrand F, Mommsen P, Schumann J, Frink M, Pape HC, Krettek C, Probst C (2009) Risk of symptomatic heterotopic ossification following plate osteosynthesis in multiple trauma patients: an analysis in a level-1 trauma centre. Scand J Trauma Resusc Emerg Med 17:55
47. Thomas EA, Cassar-Pullicino VN, McCall IW (1991) The role of ultrasound in the early diagnosis and management of heterotopic bone formation. Clin Radiol 43:190-196
48. Freed JH, Hahn H, Menter R, Dillon T (1982) The use of the three-phase bone scan in the early diagnosis of heterotopic ossification (HO) and in the evaluation of Didronel therapy. Paraplegia 20:208-216 (Pubitemid 12050090)
49. Hastings H 2nd, Graham TJ (1994) The classification and treatment of heterotopic ossification about the elbow and forearm. Hand Clin 10:417-437 (Pubitemid 24258250)
50. Gosselin RA, Belzer JP, Contreras DM (1993) Heterotopic ossification of the patellar tendon following intramedullary nailing of the tibia: report on two cases. J Trauma 34:161-163 (Pubitemid 23071139)
51. Charnley J (1972) The long-term results of low-friction arthroplasty of the hip performed as a primary intervention. J Bone Joint Surg Br 54:61-76
52. Rosendahl S, Christoffersen JK, Norgaard M (1977) Paraarticular ossification following hip replacement. 70 arthroplasties ad modum Moore using McFarland's approach. Acta Orthop Scand 48:400-404 (Pubitemid 8204956)
53. Maloney WJ, Krushell RJ, Jasty M, Harris WH (1991) Incidence of heterotopic ossification after total hip replacement: effect of the type of fixation of the femoral component. J Bone Joint Surg Am 73:191-193
54. Rockwood PR, Horne JG (1990) Heterotopic ossification following uncemented total hip arthroplasty. J Arthroplasty 5 (Suppl):S43-S46 (Pubitemid 20368600)
55. Treacy RB, McBryde CW, Pynsent PB (2005) Birmingham hip resurfacing arthroplasty. A minimum follow-up of five years. J Bone Joint Surg Br 87:167-170 (Pubitemid 40282567)
56. Amstutz HC, Beaule PE, Dorey FJ, Le Duff MJ, Campbell PA, Gruen TA (2004) Metal-on-metal hybrid surface arthroplasty: two to six-year follow-up study. J Bone Joint Surg Am 86-A:28-39 (Pubitemid 38057333)
57. Freeman MA, Bradley GW (1983) ICLH surface replacement of the hip. An analysis of the first 10 years. J Bone Joint Surg Br 65:405-411 (Pubitemid 13026746)
58. Wagner H (1978) Surface replacement arthroplasty of the hip. Clin Orthop Relat Res 134:102-130 (Pubitemid 9047593)
59. Back DL, Smith JD, Dalziel RE, Young DA, Shimmin A (2007) Incidence of heterotopic ossification after hip resurfacing. ANZ J Surg 77:642-647 (Pubitemid 47063351)
60. Rama KR, Vendittoli PA, Ganapathi M, Borgmann R, Roy A, Lavigne M (2009) Heterotopic ossification after surface replacement arthroplasty and total hip arthroplasty: a randomized study. J Arthroplasty 24:256-262
61. Hasegawa M, Ohashi T, Uchida A (2002) Heterotopic ossification around distal femur after total knee arthroplasty. Arch Orthop Trauma Surg 122:274-278 (Pubitemid 36067918)
62. Morley J, Marsh S, Drakoulakis E, Pape HC, Giannoudis PV (2005) Does traumatic brain injury result in accelerated fracture healing? Injury 36:363-368 (Pubitemid 40248388)
63. Spencer RF (1987) The effect of head injury on fracture healing. A quantitative assessment. J Bone Joint Surg Br 69:525-528 (Pubitemid 17105510)
64. Neal B, Gray H, MacMahon S, Dunn L (2002) Incidence of heterotopic bone formation after major hip surgery. ANZ J Surg 72:808-821 (Pubitemid 35370622)
65. Schandelmaier P, Krettek C, Rudolf J, Tscherne H (1995) Outcome of tibial shaft fractures with severe soft tissue injury treated by unreamed nailing versus external fixation. J Trauma 39:707-711
66. Krettek C, Rudolf J, Schandelmaier P, Guy P, Konemann B, Tscherne H (1996) Unreamed intramedullary nailing of femoral shaft fractures: operative technique and early clinical experience with the standard locking option. Injury 27:233-254 (Pubitemid 26154189)
67. Stein DA, Patel R, Egol KA, Kaplan FT, Tejwani NC, Koval KJ (2003) Prevention of heterotopic ossification at the elbow following trauma using radiation therapy. Bull Hosp Joint Dis 61:151-154 (Pubitemid 38607758)
68. Garland DE, O'Hollaren RM (1982) Fractures and dislocations about the elbow in the head-injured adult. Clin Orthop Relat Res 168:38-41 (Pubitemid 12044140)
69. Keenan MA, Kauffman DL, Garland DE, Smith C (1988) Late ulnar neuropathy in the brain-injured adult. J Hand Surg Am 13:120-124 (Pubitemid 18046025)
70. Holguin PH, Rico AA, Garcia JP, Del Rio JL (1996) Elbow anchylosis due to postburn heterotopic ossification. J Burn Care Rehabil 17:150-154 (Pubitemid 26099437)
71. Morrey BF, Askew LJ, Chao EY (1981) A biomechanical study of normal functional elbow motion. J Bone Joint Surg Am 63:872-877 (Pubitemid 11034343)
72. Chantraine A, Minaire P (1981) Para-osteo-arthropathies. A new theory and mode of treatment. Scand J Rehabil Med 13:31-37 (Pubitemid 11039442)
73. Nechwatal E (1973) Early recognition of heterotopic calcifications by means of alkaline phosphatase. Paraplegia 11:79-85
74. Heyd R, Strassmann G, Schopohl B, Zamboglou N (2001) Radiation therapy for the prevention of heterotopic ossification at the elbow. J Bone Joint Surg Br 83:332-334 (Pubitemid 32390342)
75. McAuliffe JA, Wolfson AH (1997) Early excision of heterotopic ossification about the elbow followed by radiation therapy. J Bone Joint Surg Am 79:749-755 (Pubitemid 27215410)
76. Vavken P, Castellani L, Sculco TP (2009) Prophylaxis of heterotopic ossification of the hip: systematic review and metaanalysis. Clin Orthop Relat Res 467:3283-3289
77. Viola RW, Hastings H 2nd (2000) Treatment of ectopic ossification about the elbow. Clin Orthop Relat Res 370:65-86 (Pubitemid 30059143)
78. Ritter MA, Gioe TJ (1982) The effect of indomethacin on paraarticular ectopic ossification following total hip arthroplasty. Clin Orthop Relat Res 167:113-117 (Pubitemid 12090647)
79. Cella JP, Salvati EA, Sculco TP (1988) Indomethacin for the prevention of heterotopic ossification following total hip arthroplasty. Effectiveness, contraindications, and adverse effects. J Arthroplasty 3:229-234
80. Knelles D, Barthel T, Karrer A, Kraus U, Eulert J, Kolbl O (1997) Prevention of heterotopic ossification after total hip replacement. A prospective, randomised study using acetylsalicylic acid, indomethacin and fractional or single-dose irradiation. J Bone Joint Surg Br 79:596-602
81. Sell S, Willms R, Jany R, Esenwein S, Gaissmaier C, Martini F, Bruhn G, Burkhardsmaier F, Bamberg M, Kusswetter W (1998) The suppression of heterotopic ossifications: radiation versus NSAID therapy - a prospective study. J Arthroplasty 13:854-859 (Pubitemid 29016791)
82. Fransen M, Anderson C, Douglas J, MacMahon S, Neal B, Norton R, Woodward M, Cameron ID, Crawford R, Lo SK, Tregonning G, Windolf M (2006) Safety and efficacy of routine postoperative ibuprofen for pain and disability related to ectopic bone formation after hip replacement surgery (HIPAID): randomised controlled trial. BMJ 333:519
83. Fransen M, Neal B (2004) Non-steroidal anti-inflammatory drugs for preventing heterotopic bone formation after hip arthroplasty. Cochrane Database Syst Rev CD001160.
84. Romano CL, Duci D, Romano D, Mazza M, Meani E (2004) Celecoxib versus indomethacin in the prevention of heterotopic ossification after total hip arthroplasty. J Arthroplasty 19:14-18 (Pubitemid 38112326)
85. Saudan M, Saudan P, Perneger T, Riand N, Keller A, Hoffmeyer P (2007) Celecoxib versus ibuprofen in the prevention of heterotopic ossification following total hip replacement: a prospective randomised trial. J Bone Joint Surg Br 89:155-159 (Pubitemid 46421457)
86. McLaren AC (1990) Prophylaxis with indomethacin for heterotopic bone. After open reduction of fractures of the acetabulum. J Bone Joint Surg Am 72:245-247 (Pubitemid 20123694)
87. Matta JM, Siebenrock KA (1997) Does indomethacin reduce heterotopic bone formation after operations for acetabular fractures? A prospective randomised study. J Bone Joint Surg Br 79:959-963 (Pubitemid 27499587)
88. Karunakar MA, Sen A, Bosse MJ, Sims SH, Goulet JA, Kellam JF (2006) Indometacin as prophylaxis for heterotopic ossification after the operative treatment of fractures of the acetabulum. J Bone Joint Surg Br 88:1613-1617 (Pubitemid 44970690)
89. Burd TA, Hughes MS, Anglen JO (2003) Heterotopic ossification prophylaxis with indomethacin increases the risk of longbone nonunion. J Bone Joint Surg Br 85:700-705 (Pubitemid 36927035)
90. Coventry MB, Scanlon PW (1981) The use of radiation to discourage ectopic bone. A nine-year study in surgery about the hip. J Bone Joint Surg Am 63:201-208 (Pubitemid 11154531)
91. Pellegrini VD Jr, Konski AA, Gastel JA, Rubin P, Evarts CM (1992) Prevention of heterotopic ossification with irradiation after total hip arthroplasty. Radiation therapy with a single dose of eight hundred centigray administered to a limited field. J Bone Joint Surg Am 74:186-200
92. Sylvester JE, Greenberg P, Selch MT, Thomas BJ, Amstutz H (1988) The use of postoperative irradiation for the prevention of heterotopic bone formation after total hip replacement. Int J Radiat Oncol Biol Phys 14:471-476 (Pubitemid 19241702)
93. Konski A, Weiss C, Rosier R, Poulter C, Pelligrini V, Anthony P, Evarts CM, Richardson M, Henzler M, Rubin P (1990) The use of postoperative irradiation for the prevention of heterotopic bone after total hip replacement with biologic fixation (porous coated) prosthesis: an animal model. Int J Radiat Oncol Biol Phys 18:861-865 (Pubitemid 20154044)
94. Pakos EE, Ioannidis JP (2004) Radiotherapy vs. nonsteroidal anti-inflammatory drugs for the prevention of heterotopic ossification after major hip procedures: a meta-analysis of randomized trials. Int J Radiat Oncol Biol Phys 60:888-895 (Pubitemid 39311770)
95. Haas ML, Kennedy AS, Copeland CC, Ames JW, Scarboro M, Slawson RG (1999) Utility of radiation in the prevention of heterotopic ossification following repair of traumatic acetabular fracture. Int J Radiat Oncol Biol Phys 45:461-466 (Pubitemid 29408565)
96. Gregoritch SJ, Chadha M, Pelligrini VD, Rubin P, Kantorowitz DA (1994) Randomized trial comparing preoperative versus postoperative irradiation for prevention of heterotopic ossification following prosthetic total hip replacement: preliminary results. Int J Radiat Oncol Biol Phys 30:55-62 (Pubitemid 24291114)
97. Seegenschmiedt MH, Keilholz L, Martus P, Goldmann A, Wolfel R, Henning F, Sauer R (1997) Prevention of heterotopic ossification about the hip: final results of two randomized trials in 410 patients using either preoperative or postoperative radiation therapy. Int J Radiat Oncol Biol Phys 39:161-171 (Pubitemid 27396293)
98. Ayers DC, Pellegrini VD Jr, Evarts CM (1991) Prevention of heterotopic ossification in high-risk patients by radiation therapy. Clin Orthop Relat Res 263:87-93
99. Moore KD, Goss K, Anglen JO (1998) Indomethacin versus radiation therapy for prophylaxis against heterotopic ossification in acetabular fractures: a randomised, prospective study. J Bone Joint Surg Br 80:259-263
100. Blokhuis TJ, Frolke JP (2009) Is radiation superior to indomethacin to prevent heterotopic ossification in acetabular fractures?: a systematic review. Clin Orthop Relat Res 467:526-530
101. Pakos EE, Pitouli EJ, Tsekeris PG, Papathanasopoulou V, Stafilas K, Xenakis TH (2006) Prevention of heterotopic ossification in high-risk patients with total hip arthroplasty: the experience of a combined therapeutic protocol. Int Orthop 30:79-83
102. Piatek S, Westphal T, Arbter D, Winckler S (2006) Value of a combined ossification prophylaxis with indomethacin and radiotherapy for acetabular fractures. Unfallchirurg 109:556-562 (Pubitemid 44090438)
103. Garland DE (1991) A clinical perspective on common forms of acquired heterotopic ossification. Clin Orthop Relat Res 263:13-29
104. Cobb TK, Berry DJ, Wallrichs SL, Ilstrup DM, Morrey BF (1999) Functional outcome of excision of heterotopic ossification after total hip arthroplasty. Clin Orthop Relat Res 361:131-139 (Pubitemid 29169802)
105. Jupiter JB, Ring D (1998) Operative treatment of post-traumatic proximal radioulnar synostosis. J Bone Joint Surg Am 80:248-257 (Pubitemid 28103389)