Metabolic and physiologic effects of an endotoxin challenge in healthy obese subjects

Clinical Physiology and Functional Imaging

Volumn 31, Issue 5, 2011, Pages 371-375

  Rohrer, Marcel ^a   Berger, Mette M ^a   Pittet, Yann K ^a   Delodder, Frederik ^a   Tappy, Luc ^b   Feihl, François ^a   Chioléro, René L ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Inflammation; Metabolism; Obesity; Sepsis; Stress hormone

Indexed keywords

C REACTIVE PROTEIN; ENDOTOXIN; GLUCAGON; HYDROCORTISONE; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; PLACEBO; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BLOOD SAMPLING; BODY MASS; CALORIMETRY; CONTROLLED STUDY; CROSSOVER PROCEDURE; FEMALE; HEMODYNAMICS; HUMAN; MALE; NORMAL HUMAN; OBESITY; PHYSIOLOGY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; TEMPERATURE;

ADULT; ANALYSIS OF VARIANCE; BIOLOGICAL MARKERS; BLOOD PRESSURE; BODY MASS INDEX; BODY TEMPERATURE; C-REACTIVE PROTEIN; CALORIMETRY, INDIRECT; CARDIAC OUTPUT; CROSS-OVER STUDIES; FEMALE; GLUCAGON; HEART RATE; HEMODYNAMICS; HUMANS; HYDROCORTISONE; INFLAMMATION MEDIATORS; INJECTIONS, INTRAVENOUS; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MALE; OBESITY; PROSPECTIVE STUDIES; SINGLE-BLIND METHOD; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79960559847     PISSN: 14750961     EISSN: 1475097X     Source Type: Journal    
DOI: 10.1111/j.1475-097X.2011.01026.x     Document Type: Article

References (9)

1. Creely SJ, McTernan PG, Kusminski CM, Fisher M, Da Silva NF, Khanolkar M, Evans M, Harte AL, Kumar S. Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes. Am J Physiol Endocrinol Metab (2007); 292: E740-E747.
2. Engelberger RP, Pittet YK, Henry H, Delodder F, Hayoz D, Chiolero RL, Waeber B, Liaudet L, Berger MM, Feihl F. Acute endotoxemia inhibits microvascular nitric oxide-dependent vasodilation in humans. Shock (2011); 35: 28-34.
3. Kueht ML, McFarlin BK, Lee RE. Severely obese have greater LPS-stimulated TNF-alpha production than normal weight African-American women. Obesity (Silver Spring) (2009); 17: 447-451.
4. Livesey G, Elia M. Estimation of energy expenditure, net carbohydrate utilization, and net fat oxidation and synthesis by indirect calorimetry: evaluation of errors with special reference to detailed composition of fuels. Am J Clin Nutr (1988); 47: 608-628.
5. Newell MA, Bard MR, Goettler CE, Toschlog EA, Schenarts PJ, Sagraves SG, Holbert D, Pories WJ, Rotondo MF. Body mass index and outcomes in critically injured blunt trauma patients: weighing the impact. J Am Coll Surg (2007); 204: 1056-1061. discussion 1062-1054.
6. Pittet YK, Berger MM, Pluess TT, Voirol P, Revelly JP, Tappy L, Chiolero RL. Blunting the response to endotoxin in healthy subjects: effects of various doses of intravenous fish oil. Intensive Care Med (2010); 36: 289-298.
7. Pluess TT, Hayoz D, Berger MM, Tappy L, Revelly JP, Michaeli B, Carpentier YA, Chiolero RL. Intravenous fish oil blunts the physiological response to endotoxin in healthy subjects. Intensive Care Med (2007); 33: 789-797.
8. Schultz MJ, van der Poll T. Animal and human models for sepsis. Ann Med (2002); 34: 573-581.
9. Trayhurn P. Adipose tissue in obesity-an inflammatory issue. Endocrinology (2005); 146: 1003-1005.