Association of cerebrospinal fluid analysis findings with clinical signs and outcome in acute nonambulatory thoracolumbar disc disease in dogs

Journal of Veterinary Internal Medicine

Volumn 25, Issue 4, 2011, Pages 846-855

  Srugo, Itay ^a   Aroch, I ^a   Christopher, M ^b   Chai, O ^a   Goralnik, L ^a   Bdolah Abram, T ^a   Shamir, M H ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Canine; Intervertebral disc disease; Pleocytosis; Prognosis

Indexed keywords

ANIMAL; ANIMAL DISEASE; ARTICLE; CEREBROSPINAL FLUID; CHEMISTRY; CYTOLOGY; DISKITIS; DOG; DOG DISEASE; ERYTHROCYTE COUNT; INTERVERTEBRAL DISK DEGENERATION; INTERVERTEBRAL DISK HERNIA; LAMINECTOMY; NONPARAMETRIC TEST; PATHOPHYSIOLOGY; PREDICTIVE VALUE; RECEIVER OPERATING CHARACTERISTIC; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; VERTEBRA;

ANIMALS; CEREBROSPINAL FLUID; DOG DISEASES; DOGS; ERYTHROCYTE COUNT; INTERVERTEBRAL DISC DEGENERATION; INTERVERTEBRAL DISC DISPLACEMENT; LAMINECTOMY; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; ROC CURVE; SENSITIVITY AND SPECIFICITY; STATISTICS, NONPARAMETRIC; THORACIC VERTEBRAE;

ANIMALIA; CANIS FAMILIARIS;

EID: 79960558185     PISSN: 08916640     EISSN: 19391676     Source Type: Journal    
DOI: 10.1111/j.1939-1676.2011.0739.x     Document Type: Article

References (34)

1. Coates JR. Intervertebral disk disease. Vet Clin North Am Small Anim Pract 2000;30:77-110.
2. Sharp NJH, Wheeler SJ. Thoracolumbar disc disease. In: Sharp NJH, Wheeler SJ, eds. Small Animal Spinal Disorders Diagnosis and Surgery, 2nd ed. Philadelphia, PA: Elsevier Mosby; 2005:121-160.
3. Ruddle TL, Allen DA, Schertel ER, et al. Outcome and prognostic factors in non-ambulatory Hansen Type I intervertebral disc extrusions: 308 cases. Vet Comp Orthop Traumatol 2006;19:29-34.
4. Davis GJ, Brown DC. Prognostic indicators for time to ambulation after surgical decompression in nonambulatory dogs with acute thoracolumbar disk extrusions: 112 cases. Vet Surg 2002;31:513-518.
5. Penning V, Platt SR, Dennis R, et al. Association of spinal cord compression seen on magnetic resonance imaging with clinical outcome in 67 dogs with thoracolumbar intervertebral disc extrusion. J Small Anim Pract 2006;47:644-650.
6. Duval J, Dewey C, Roberts R, et al. Spinal cord swelling as a myelographic indicator of prognosis: A retrospective study in dogs with intervertebral disc disease and loss of deep pain perception. Vet Surg 1996;25:6-12.
7. Levine JM, Fosgate GT, Chen AV, et al. Magnetic resonance imaging in dogs with neurologic impairment due to acute thoracic and lumbar intervertebral disk herniation. J Vet Intern Med 2009;23:1220-1226.
8. Ito D, Matsunaga S, Jeffery ND, et al. Prognostic value of magnetic resonance imaging in dogs with paraplegia caused by thoracolumbar intervertebral disk extrusion: 77 cases (2000-2003). J Am Vet Med Assoc 2005;227:1454-1460.
9. Knecht CD. Results of surgical treatment for thoracolumbar disc protrusion. J Small Anim Pract 1972;13:449-453.
10. Thomson C.E., Kornegay JN, Stevens JB. Canine intervertebral disc disease: Changes in the cerebrospinal fluid Page: 1. J Small Anim Pract 1989;30:685-688.
11. Bohn AA, Wills TB, West CL, et al. Cerebrospinal fluid analysis and magnetic resonance imaging in the diagnosis of neurologic disease in dogs: A retrospective study. Vet Clin Pathol 2006;35:315-320.
12. Windsor RC, Vernau KM, Sturges BK, et al. Lumbar cerebrospinal fluid in dogs with type I intervertebral disc herniation. J Vet Intern Med 2008;22:954-960.
13. Dewey CW. Myelopathies: Disorders of the spinal cord. In: Dewey CW, ed. A Practical Guide to Canine & Feline Neurology, 2nd ed. Ames, IA: Wiley-Blackwell; 2008:323-389.
14. Levine GJ, Levine JM, Witsberger TH, et al. Cerebrospinal fluid myelin basic protein as a prognostic biomarker in dogs with thoracolumbar intervertebral disk herniation. J Vet Intern Med 2010;24:890-896.
15. Doyle C, Solano-Gallego L. Cytologic interpretation of canine cerebrospinal fluid samples with low total nucleated cell concentration, with and without blood contamination. Vet Clin Pathol 2009;38:392-396.
16. Chrisman CL. Cerebrospinal fluid analysis. Vet Clin North Am Small Anim Pract 1992;22:781-810.
17. Wamsley H, Alleman AR. Clinical pathology. In: Platt SR, Olby N, eds. BSAVA Manual of Canine and Feline Neurology, 3rd ed. Gloucester, UK: British Small Animal Veterinary Association; 2004:35-53.
18. Christopher MM, Perman V, Hardy RM. Reassessment of cytologic values in canine cerebrospinal fluid by use of cytocentrifugation. J Am Vet Med Assoc 1988;192:1726-1729.
19. Olby NJ, De Risio L, Munana KR, et al. Development of a functional scoring system in dogs with acute spinal cord injuries. Am J Vet Res 2001;62:1624-1628.
20. Kwon BK, Stammers AM, Belanger LM, et al. Cerebrospinal fluid inflammatory cytokines and biomarkers of injury severity in acute human spinal cord injury. J Neurotrauma 2010;27:669-682.
21. Taoka Y, Okajima K, Uchiba M, et al. Role of neutrophils in spinal cord injury in the rat. Neuroscience 1997;79:1177-1182.
22. Hausmann ON. Post-traumatic inflammation following spinal cord injury. Spinal Cord 2003;41:369-378.
23. Popovich PG, Wei P, Stokes BT. Cellular inflammatory response after spinal cord injury in Sprague-Dawley and Lewis rats. J Comp Neurol 1997;377:443-464.
24. Sroga JM, Jones TB, Kigerl KA, et al. Rats and mice exhibit distinct inflammatory reactions after spinal cord injury. J Comp Neurol 2003;462:223-240.
25. Popovich PG, Guan Z, Wei P, et al. Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury. Exp Neurol 1999;158:351-365.
26. Popovich PG, Guan Z, McGaughy V, et al. The neuropathological and behavioral consequences of intraspinal microglial/macrophage activation. J Neuropathol Exp Neurol 2002;61:623-633.
27. Fleming JC, Norenberg MD, Ramsay DA, et al. The cellular inflammatory response in human spinal cords after injury. Brain 2006;129:3249-3269.
28. Schwartz M. Macrophages and microglia in central nervous system injury: Are they helpful or harmful? J Cereb Blood Flow Metab 2003;23:385-394.
29. Blight AR. Delayed demyelination and macrophage invasion: A candidate for secondary cell damage in spinal cord injury. Cent Nerv Syst Trauma 1985;2:299-315.
30. Gowing G, Lalancette-Hebert M, Audet JN, et al. Macrophage colony stimulating factor (M-CSF) exacerbates ALS disease in a mouse model through altered responses of microglia expressing mutant superoxide dismutase. Exp Neurol 2009;220:267-275.
31. Hurtt AE, Smith MO. Effects of iatrogenic blood contamination on results of cerebrospinal fluid analysis in clinically normal dogs and dogs with neurologic disease. J Am Vet Med Assoc 1997;211:866-867.
32. Thomson CE, Kornegay JN, Stevens JB. Analysis of cerebrospinal fluid from the cerebellomedullary and lumbar cisterns of dogs with focal neurologic disease: 145 cases (1985-1987). J Am Vet Med Assoc 1990;196:1841-1844.
33. Levine JM, Ruaux CG, Bergman RL, et al. Matrix metalloproteinase-9 activity in the cerebrospinal fluid and serum of dogs with acute spinal cord trauma from intervertebral disk disease. Am J Vet Res 2006;67:283-287.
34. De Risio L, Adams V, Dennis R, et al. Association of clinical and magnetic resonance imaging findings with outcome in dogs with presumptive acute noncompressive nucleus pulposus extrusion: 42 cases (2000-2007). J Am Vet Med Assoc 2009;234:495-504.