Protection against enamel demineralisation using toothpastes containing o-cymen-5-ol, zinc chloride and sodium fluoride

International Dental Journal

Volumn 61, Issue SUPPL. 3, 2011, Pages 55-59

  Churchley, David ^a   Newby, Craig S ^a   Willson, Richard ^b   Haider, Amir ^c   Schemehorn, Bruce ^c   Lynch, Richard J M ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY OF READING   (United Kingdom)

^c Therametric Technologies Inc   (United States)

Author keywords

Demineralisation; Zinc

Indexed keywords

ANTICARIES AGENT; CHLORIDE; FLUORIDE SODIUM; O CYMEN 5 OL; O-CYMEN-5-OL; PHENOL DERIVATIVE; TOOTHPASTE; ZINC CHLORIDE; ZINC DERIVATIVE;

ANALYSIS OF VARIANCE; ARTICLE; CHEMISTRY; DENTAL CARE; DRUG EFFECT; HARDNESS; HUMAN; PH; TOOTH DISEASE;

ANALYSIS OF VARIANCE; CARIOSTATIC AGENTS; CHLORIDES; HARDNESS; HUMANS; HYDROGEN-ION CONCENTRATION; PHENOLS; SODIUM FLUORIDE; TOOTH DEMINERALIZATION; TOOTH REMINERALIZATION; TOOTHPASTES; ZINC COMPOUNDS;

EID: 79960545055     PISSN: 00206539     EISSN: 1875595X     Source Type: Journal    
DOI: 10.1111/j.1875-595X.2011.00050.x     Document Type: Article

References (25)

1. Marinho VC, Higgins JP, Sheiham A, et al., Fluoride toothpastes for preventing dental caries in children and adolescents. Cochrane Database Syst Rev 2003 Issue 1: CD002278. Review.
2. Marquis RE, Clock SA, Mota-Meira M,. Fluoride and organic weak acids as modulators of microbial physiology. FEMS Microbiol Rev 2003 26: 493-510. (Pubitemid 36183529)
3. Saxton CA, Harrap GJ, Lloyd AM,. The effect of dentifrices containing zinc citrate on plaque growth and oral zinc levels. J Clin Periodontol 1986 13: 301-306. (Pubitemid 16087142)
4. Jonski G, Young A, Waler SM, et al., Insoluble zinc, cupric and tin pyrophosphates inhibit the formation of volatile sulphur compounds. Eur J Oral Sci 2004 112: 429-432. (Pubitemid 39456959)
5. LeGeros RZ, Bleiwas CB, Retino M, et al., Zinc effect on the invitro formation of calcium phosphates: Relevance to clinical inhibition of calculus formation. Am J Den 1999 12: 65-71.
6. ten Cate JM,. The caries preventative effect of a fluoride dentifrice containing Triclosan and zinc citrate, a compilation of in vitro and in situ studies. Int Dent J 1993 43: 401-413.
7. Laucello M, Noel N, Ferro R, et al., The anti-caries efficacy of a silica-based fluoride toothpaste containing zinc citrate, triclosan, vitamin E and sunflower oil. Int Dent J 2007 57: 145-149.
8. Mellberg JR, Chomicki WG,. Effect of zinc citrate on fluoride uptake by artificial caries lesions. J Dent Res 1983 62: 145-147. (Pubitemid 13081994)
9. Ingram GS, Baker AG, Best JS, et al., The influence of zinc citrate in a fluoride dentifrice on rat caries and fluoride content of molar enamel in vivo. J Dent Res 1984 63: 497.
10. Stephen KW, Creanor SL, Russell JI, et al., A 3-year oral health dose-response study of sodium monofluorophosphate dentifrices with and without zinc citrate: anti-caries results. Community Dent Oral Epidemiol 1988 16: 321-325.
11. Featherstone JDB, O'Reilly MM, Shariati M, et al., Enhancement of remineralization in vitro and in vivo. In:, Leach SA, editor. Factors Relating to Demineralisation and Remineralisation of the Teeth, Oxford: IRL Press Ltd; 1986. p. 23-34.
12. Featherstone JDB, ten Cate JM, Shariati M, et al., Comparison of artificial caries-like lesions by quantitative microradiography and microhardness profiles. Caries Res 1983 17: 385-391.
13. ten Cate JM, Shariati M, Featherstone JDB,. Enhancement of salivary remineralization by 'dipping' solutions. Caries Res 1985 19: 335-341. (Pubitemid 15058600)
14. Brudevold FL, Steadman T, Spinelli MA, et al., A study of zinc in human teeth. Arch Oral Biol 1963 8: 135-144.
15. Dedhiya MG, Young F, Higuchi WI,. Mechanism for the retardation of the acid dissolution rate of hydroxyapatite by strontium. J Dent Res 1973 52: 1097-1109.
16. Brookes SJ, Shore RC, Robinson C, et al., Copper ions inhibit the demineralisation of human enamel. Arch Oral Biol 2003 48: 25-30. (Pubitemid 36453325)
17. O'Reilly MM, Featherstone JDB,. De- and remineralisation around orthodontic appliances: an in vivo study. Am J Orthod 1987 92: 33.
18. Fejerskov O, Nyvad B, Kidd EAM,. Pathology in Dental Caries. In:, Fejerskov O, Kidd EAM, editors. Dental caries: the disease and its clinical management, 2nd ed. Oxford: Blackwell Munksgaard, 2008. p. 19-48.
19. Imanishi H, Nishino M,. Post eruptive maturation of immature young permanent enamel. J Int Ass Dent Child 1983 14: 49-54.
20. Fejerskov O, Josephsen K, Nyvad B,. Surface ultrastructure of unerupted mature human enamel. Caries Res 1984 18: 302-314.
21. Lynch RJM, Churchley DR, Cooper L, et al., Effect of zinc and fluoride on the remineralisation of early carious lesions under simulated plaque-fluid conditions. Caries Res 2011 45: 313-322. in press.
22. Lippert F, Zero DR,. Dose-response effects of zinc and fluoride on caries lesion remineralisation. IADR 2011 Abstract #1548
23. Ingram GS, Horay CP, Stead WJ,. Interaction of zinc with dental mineral. Caries Res 1992 24: 248-255.
24. Dybowska A, Manning DAC, Collins MJ, et al., An evaluation of the reactivity of synthetic and natural apatites in the presence of aqueous metals. Sci Total Natural Environ 2009 407: 2953-2965.
25. Lingawi H, Barbour M, Lynch RJM, et al., Effect of zinc ions (Zn+2) on hydroxyapatite dissolution kinetics studied using scanning microradiography. Caries Res 2011 45: 195.