Real-Time quantitative polymerase chain reaction analysis of patients with refractory chronic periodontitis

Journal of Periodontology

Volumn 82, Issue 7, 2011, Pages 1018-1024

  Marconcini, Simone ^a,b   Covani, Ugo ^b,c   Barone, Antonio ^a,b   Vittorio, Orazio ^c   Curcio, Michele ^d   Barbuti, Serena ^d   Scatena, Fabrizio ^d   Felli, Lamberto ^a   Nicolini, Claudio ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b Tirrenic Odontostomatologic Institute   (Italy)

^c UNIVERSITY OF PISA   (Italy)

^d CISANELLO HOSPITAL   (Italy)

Author keywords

Bioinformatics; Genes; Periodontitis; Polymerase chain reaction

Indexed keywords

GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GRB2 PROTEIN, HUMAN; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NFKB1 PROTEIN, HUMAN; ONCOPROTEIN; TRANSCRIPTION FACTOR RELA;

ADULT; AGGRESSIVE PERIODONTITIS; ARTICLE; BIOLOGY; CHRONIC PERIODONTITIS; COMPARATIVE STUDY; DISEASE COURSE; FEMALE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; HUMAN; MALE; METHODOLOGY; MIDDLE AGED; POLYMERASE CHAIN REACTION;

ADULT; AGGRESSIVE PERIODONTITIS; CHRONIC PERIODONTITIS; COMPUTATIONAL BIOLOGY; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; GRB2 ADAPTOR PROTEIN; HUMANS; MALE; MIDDLE AGED; NF-KAPPA B P50 SUBUNIT; ONCOGENE PROTEIN V-CBL; POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTOR RELA;

EID: 79960523655     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2010.100312     Document Type: Article

References (39)

1. Nibali L, Donos N, Brett PM, et al. A familial analysis of aggressive periodontitis - Clinical and genetic findings. J Periodontal Res 2008;43:627-634.
2. Weidlich P, Cimões R, Pannuti CM, Oppermann RV. Association between periodontal diseases and systemic diseases. Braz Oral Res 2008;22(Suppl. 1):32-43.
3. Beck JD, Koch GG, Rozier RG, Tudor GE. Prevalence and risk indicators for periodontal attachment loss in a population of older community-dwelling blacks and whites. J Periodontol 1990;61:521-528.
4. Moimaz SA, Zina LG, Saliba O, Garbin CA. Smoking and periodontal disease: Clinical evidence for an association. Oral Health Prev Dent 2009;7:369-376.
5. Rodenburg JP, van Winkelhoff AJ, Winkel EG, Goené RJ, Abbas F, de Graff J. Occurrence of Bacteroides gingivalis, Bacteroides intermedius and Actinobacillus actinomycetemcomitans in severe periodontitis in relation to age and treatment history. J Clin Periodontol 1990;17:392-399. (Pubitemid 20197751)
6. Grbic JT, Lamster IB, Celenti RS, Fine JB. Risk indicators for future clinical attachment loss in adult periodontitis. Patient variables. J Periodontol 1991;62: 322-329.
7. Haffajee AD, Uzel NG, Arguello EI, Torresyap G, Guerrero DM, Socransky SS. Clinical and microbiological changes associated with the use of combined antimicrobial therapies to treat "refractory" periodontitis. J Clin Periodontol 2004;31:869-877. (Pubitemid 39387418)
8. Hirschfeld L, Wasserman B. A long-term survey of tooth loss in 600 treated periodontal patients. J Periodontol 1978;49:225-237. (Pubitemid 8358380)
9. McFall WT Jr. Tooth loss in 100 treated patients with periodontal disease. A long-term study. J Periodontol 1982;53:539-549. (Pubitemid 13242886)
10. Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999;4:1-6.
11. Tabor HK, Risch NJ, Myers RM. Candidate-gene approaches for studying complex genetic traits: Practical considerations. Nat Rev Genet 2002;3:391-397. (Pubitemid 34506720)
12. Hirschhorn JN. Genetic approaches to studying common diseases and complex traits. Pediatr Res 2005; 57:74R-77R. (Pubitemid 40593249)
13. Hart TC, Marazita ML, Wright JT. The impact of molecular genetics on oral health paradigms. Crit Rev Oral Biol Med 2000;11:26-56. (Pubitemid 30080931)
14. Michalowicz BS, Diehl SR, Gunsolley JC, et al. Evidence of a substantial genetic basis for risk of adult periodontitis. J Periodontol 2000;71:1699-1707.
15. Hart TC. Genetic considerations of risk in human periodontal disease. Curr Opin Periodontol 1994;3-11.
16. Walker SJ, Van Dyke TE, Rich S, Kornman KS, di Giovine FS, Hart TC. Genetic polymorphisms of the IL- 1alpha and IL-1beta genes in African-American LJP patients and an African-American control population. J Periodontol 2000;71:723-728.
17. Sivozhelezov V, Giacomelli L, Tripathi S, Nicolini C. Gene expression in the cell cycle of human T lymphocytes: I. Predicted gene and protein networks. J Cell Biochem 2006;97:1137-1150.
18. Nicolini C, Spera R, Stura E, Fiordoro S, Giacomelli L. Gene expression in the cell cycle of human T-lymphocytes: II. Experimental determination by DNASER technology. J Cell Biochem 2006;97:1151-1159.
19. von Mering C, Jensen LJ, Snel B, et al. STRING: Known and predicted protein-protein associations, integrated and transferred across organisms. Nucleic Acids Res 2005;33(Database issue):D433-D437. (Pubitemid 40207910)
20. Covani U, Marconcini S, Giacomelli L, Sivozhelevov V, Barone A, Nicolini C. Bioinformatic prediction of leader genes in human periodontitis. J Periodontol 2008;79:1974-1983.
21. Genco RJ, Slots J. Host responses in periodontal diseases. J Dent Res 1984;63:441-451.
22. World Medical Association. World Medical Association Declaration of Helsinki: Ethical principles for medical research involving human subjects. JAMA 2000;284: 3043-3045.
23. Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999;4:1-6.
24. Kinane DF, Lappin DF. Immune processes in periodontal disease: A review. Ann Periodontol 2002;7: 62-71.
25. Nisengard RJ. The role of immunology in periodontal disease. J Periodontol 1977;48:505-516. (Pubitemid 8194162)
26. van Winkelhoff AJ, van Steenbergen TJ, de Graaff J. The role of black-pigmented Bacteroides in human oral infections. J Clin Periodontol 1988;15:145-155. (Pubitemid 18072834)
27. Dahlén G. Role of suspected periodontopathogens in microbiological monitoring of periodontitis. Adv Dent Res 1993;7:163-174.
28. van Winkelhoff AJ, Boutaga K. Transmission of periodontal bacteria and models of infection. J Clin Periodontol 2005;32(Suppl. 6):16-27. (Pubitemid 41391053)
29. Nicolini C. Nanogenomics for medicine. Nanomedicine (Lond) 2006;1:147-152.
30. Giacomelli L, Nicolini C. Gene expression of human T lymphocytes cell cycle: Experimental and bioinformatic analysis. J Cell Biochem 2006;99:1326-1333.
31. Bruzzaniti A, Neff L, Sanjay A, Horne WC, De Camilli P, Baron R. Dynamin forms a Src kinase-sensitive complex with Cbl and regulates podosomes and osteoclast activity. Mol Biol Cell 2005;16:3301-3313. (Pubitemid 40962599)
32. Spinardi L, Marchisio PC. Podosomes as smart regulators of cellular adhesion. Eur J Cell Biol 2006;85: 191-194.
33. Ochoa GC, Slepnev VI, Neff L, et al. A functional link between dynamin and the actin cytoskeleton at podosomes. J Cell Biol 2000;150:377-389. (Pubitemid 30491360)
34. Horne WC, Sanjay A, Bruzzaniti A, Baron R. The role(s) of Src kinase and Cbl proteins in the regulation of osteoclast differentiation and function. Immunol Rev 2005;208:106-125. (Pubitemid 41746388)
35. Chiusaroli R, Sanjay A, Henriksen K, et al. Deletion of the gene encoding c-Cbl alters the ability of osteoclasts to migrate, delaying resorption and ossification of cartilage during the development of long bones. Dev Biol 2003;261:537-547. (Pubitemid 37108791)
36. Yulug IG, Egan SE, See CG, Fisher EM. Mapping GRB2, a signal transduction gene in the human and the mouse. Genomics 1994;22:313-318. (Pubitemid 24258871)
37. Rozakis-Adcock M, McGlade J, Mbamalu G, et al. Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases. Nature 1992;360:689-692. (Pubitemid 23007687)
38. Rozakis-Adcock M, Fernley R, Wade J, Pawson T, Bowtell D. The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1. Nature 1993;363:83-85. (Pubitemid 23144967)
39. Wang Z, Moran MF. Requirement for the adapter protein GRB2 in EGF receptor endocytosis. Science 1996;272:1935-1939. (Pubitemid 26234504)