Resistance to the third-generation cephalosporin ceftazidime by a deacylation-deficient mutant of the TEM β-lactamase by the uncommon covalent-trapping mechanism

Biochemistry

Volumn 50, Issue 29, 2011, Pages 6387-6395

  Antunes, Nuno T ^a   Frase, Hilary ^a   Toth, Marta ^a   Mobashery, Shahriar ^a   Vakulenko, Sergei B ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SUBSTITUTION; CEFTAZIDIME; CLASS A; COMPUTER MODELING; COVALENT COMPLEX; DOUBLE MUTANTS; EXPERIMENTAL DATA; LACTAMASES; MINIMAL INHIBITORY CONCENTRATION; THIRD GENERATION; TIME-PERIODS; WILD-TYPE ENZYMES;

AMINO ACIDS; BACTERIOLOGY; ENZYMES; ESCHERICHIA COLI; RATE CONSTANTS;

SEWAGE TREATMENT PLANTS;

AMPICILLIN; ARGININE; AZTREONAM; BETA LACTAMASE TEM 1; CEFALOTIN; CEFEPIME; CEFOTAXIME; CEFOXITIN; CEFTAZIDIME; CEFTRIAXONE; CEFUROXIME; GLUTAMIC ACID; KANAMYCIN; LATAMOXEF; METHIONINE; NITROCEFIN; OXACILLIN; PENICILLIN G; PIPERACILLIN; THREONINE; TICARCILLIN;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; COVALENT BOND; DEACYLATION; ESCHERICHIA COLI; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR MODEL; MUTANT; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE;

ACYLATION; BETA-LACTAMASES; CEFTAZIDIME; COMPUTER SIMULATION; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HYDROLYSIS; KINETICS; MICROBIAL SENSITIVITY TESTS; MODELS, BIOLOGICAL; MUTANT PROTEINS; TIME FACTORS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 79960479321     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200403e     Document Type: Article

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