Insights into ectopic estrogen receptor expression, nucleocytoplasmic distribution and interaction with chromatin obtained with new antibodies to estrogen receptors α and β

Steroids

Volumn 76, Issue 10-11, 2011, Pages 974-985

  Chantzi, Niki I ^a,b   Meligova, Aggeliki K ^a   Dhimolea, Eugen ^a   Petrou, Christos C ^c   Mitsiou, Dimitra J ^a   Magafa, Vassiliki ^c   Pechtelidou, Anastasia ^a   Florentin, Ida ^a   Kitraki, Efthimia ^d   Cordopatis, Paul ^c   Tiniakos, Dina G ^b   Alexis, Michael N ^a  

^a INSTITUTE OF BIOLOGY   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^c UNIVERSITY OF PATRAS   (Greece)

^d NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

Author keywords

Chromatin immunoprecipitation; Estrogen receptor; Monoclonal antibodies

Indexed keywords

ANTIESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR ALPHA ANTIBODY; ESTROGEN RECEPTOR BETA; ESTROGEN RECEPTOR BETA 1; ESTROGEN RECEPTOR BETA 1 ANTIBODY; LUCIFERASE; RECEPTOR ANTIBODY; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL LINE; CELL NUCLEUS; CELL STRAIN HEK293; CELL STRAIN MCF 7; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CYTOPLASM; ESTROGEN RESPONSIVE ELEMENT; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; NUCLEOCYTOPLASMIC TRANSPORT; PROTEIN EXPRESSION; VALIDATION STUDY; WILD TYPE;

ANTIBODIES, MONOCLONAL; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL NUCLEUS; CHROMATIN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; POLYMERASE CHAIN REACTION; PROTEIN BINDING;

EID: 79960462107     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2011.05.010     Document Type: Article

References (40)

1. K. Dahlman-Wright, V. Cavailles, S.A. Fuqua, V.C. Jordan, J.A. Katzenellenbogen, and K.S. Korach International union of pharmacology. LXIV. Estrogen receptors Pharmacol Rev 58 2006 773 781 (Pubitemid 44833745)
2. J.T. Moore, D.D. McKee, K. Slentz-Kesler, L.B. Moore, S.A. Jones, and E.L. Horne Cloning and characterization of human estrogen receptor beta isoforms Biochem Biophys Res Commun 247 1998 75 78 (Pubitemid 28412528)
3. S. Ogawa, S. Inoue, T. Watanabe, A. Orimo, T. Hosoi, and Y. Ouchi Molecular cloning and characterization of human estrogen receptor betacx: a potential inhibitor of estrogen action in human Nucleic Acids Res 26 1998 3505 3512 (Pubitemid 28347221)
4. E. Leygue, H. Dotzlaw, B. Lu, C. Glor, P.H. Watson, and L.C. Murphy Estrogen receptor beta: mine is longer than yours? J Clin Endocrinol Metab 83 1998 3754 3755 (Pubitemid 28500922)
5. G.A. Scobie, S. Macpherson, M.R. Millar, N.P. Groome, P.G. Romana, and P.T. Saunders Human oestrogen receptors: differential expression of ER alpha and beta and the identification of ER beta variants Steroids 67 2002 985 992 (Pubitemid 35175466)
6. T.L. Ramsey, K.E. Risinger, S.C. Jernigan, K.A. Mattingly, and C.M. Klinge Estrogen receptor beta isoforms exhibit differences in ligand-activated transcriptional activity in an estrogen response element sequence-dependent manner Endocrinology 145 2004 149 160 (Pubitemid 38094510)
7. Y. Tateishi, R. Sonoo, Y. Sekiya, N. Sunahara, M. Kawano, and M. Wayama Turning off estrogen receptor beta-mediated transcription requires estrogen-dependent receptor proteolysis Mol Cell Biol 26 2006 7966 7976 (Pubitemid 44630996)
8. P.T. Saunders, M.R. Millar, K. Williams, S. Macpherson, C. Bayne, and C. O'Sullivan Expression of oestrogen receptor beta (ERbeta1) protein in human breast cancer biopsies Br J Cancer 86 2002 250 256 (Pubitemid 34185154)
9. 2- terminal domain of the estrogen receptor beta correlates with the survival of breast cancer patients Cancer Res 66 2006 2716 2724
10. G.P. Skliris, E. Leygue, P.H. Watson, and L.C. Murphy Estrogen receptor alpha negative breast cancer patients: estrogen receptor beta as a therapeutic target J Steroid Biochem Mol Biol 109 2008 1 10
11. J. Hartman, A. Strom, and J.A. Gustafsson Estrogen receptor beta in breast cancer - diagnostic and therapeutic implications Steroids 74 2009 635 641
12. A.M. Shaaban, A.R. Green, S. Karthik, Y. Alizadeh, T.A. Hughes, and L. Harkins Nuclear and cytoplasmic expression of ERbeta1, ERbeta2, and ERbeta5 identifies distinct prognostic outcome for breast cancer patients Clin Cancer Res 14 2008 5228 5235
13. A.M. Shaaban, C. Jarvis, F. Moore, C. West, A. Dodson, and C.S. Foster Prognostic significance of estrogen receptor beta in epithelial hyperplasia of usual type with known outcome Am J Surg Pathol 29 2005 1593 1599
14. P.R. Cammarata, J. Flynn, S. Gottipati, S. Chu, S. Dimitrijevich, and M. Younes Differential expression and comparative subcellular localization of estrogen receptor beta isoforms in virally transformed and normal cultured human lens epithelial cells Exp Eye Res 81 2005 165 175 (Pubitemid 41080098)
15. L.A. Helguero, M.H. Faulds, J.A. Gustafsson, and L.A. Haldosen Estrogen receptors alfa (ERalpha) and beta (ERbeta) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11 Oncogene 24 2005 6605 6616 (Pubitemid 41486791)
16. A. Pedram, M. Razandi, D.C. Wallace, and E.R. Levin Functional estrogen receptors in the mitochondria of breast cancer cells Mol Biol Cell 17 2006 2125 2137 (Pubitemid 44011729)
17. A.S. Al-Madhoun, Y.X. Chen, L. Haidari, K. Rayner, W. Gerthoffer, and H. McBride The interaction and cellular localization of HSP27 and ERbeta are modulated by 17beta-estradiol and HSP27 phosphorylation Mol Cell Endocrinol 270 2007 33 42 (Pubitemid 46670548)
18. M.M. Ivanova, W. Mazhawidza, S.M. Dougherty, and C.M. Klinge Sex differences in estrogen receptor subcellular location and activity in lung adenocarcinoma cells Am J Respir Cell Mol Biol 42 2010 320 330
19. L.C. Murphy, B. Peng, A. Lewis, J.R. Davie, E. Leygue, and A. Kemp Inducible upregulation of oestrogen receptor-beta1 affects oestrogen and tamoxifen responsiveness in MCF7 human breast cancer cells J Mol Endocrinol 34 2005 553 566 (Pubitemid 40585201)
20. T.H. Charn, E.T. Liu, E.C. Chang, Y.K. Lee, J.A. Katzenellenbogen, and B.S. Katzenellenbogen Genome-wide dynamics of chromatin binding of estrogen receptors alpha and beta: mutual restriction and competitive site selection Mol Endocrinol 24 2010 47 59
21. Y.K. Leung, P. Mak, S. Hassan, and S.M. Ho Estrogen receptor (ER)-beta isoforms: a key to understanding ER-beta signaling Proc Natl Acad Sci USA 103 2006 13162 13167 (Pubitemid 44338933)
22. E. Badia, A. Escande, P. Balaguer, R. Metivier, and V. Cavailles New stably transfected bioluminescent cells expressing FLAG epitope-tagged estrogen receptors to study their chromatin recruitment BMC Biotechnol 9 2009 77
23. C. Zhao, M. Putnik, J.A. Gustafsson, and K. Dahlman-Wright Microarray analysis of altered gene expression in ERbeta-overexpressing HEK293 cells Endocrine 36 2009 224 232
24. Z. Papoutsi, C. Zhao, M. Putnik, J.A. Gustafsson, and K. Dahlman-Wright Binding of estrogen receptor alpha/beta heterodimers to chromatin in MCF-7 cells J Mol Endocrinol 43 2009 65 72
25. G.E. Weitsman, G. Skliris, K. Ung, B. Peng, M. Younes, and P.H. Watson Assessment of multiple different estrogen receptor-beta antibodies for their ability to immunoprecipitate under chromatin immunoprecipitation conditions Breast Cancer Res Treat 100 2006 23 31
26. S.M. Cowley, and M.G. Parker A comparison of transcriptional activation by ER alpha and ER beta J Steroid Biochem Mol Biol 69 1999 165 175 (Pubitemid 29305534)
27. A.D. Gritzapis, C.N. Baxevanis, I. Missitzis, E.S. Katsanou, M.N. Alexis, and J. Yotis Quantitative fluorescence cytometric measurement of estrogen and progesterone receptors: correlation with the hormone binding assay Breast Cancer Res Treat 80 2003 1 13 (Pubitemid 36851280)
28. N. Fokialakis, G. Lambrinidis, D.J. Mitsiou, N. Aligiannis, S. Mitakou, and A.L. Skaltsounis A new class of phytoestrogens; evaluation of the estrogenic activity of deoxybenzoins Chem Biol 11 2004 397 406 (Pubitemid 39403879)
29. M. Halabalaki, X. Alexi, N. Aligiannis, G. Lambrinidis, H. Pratsinis, and I. Florentin Estrogenic activity of isoflavonoids from Onobrychis ebenoides Planta Med 72 2006 488 493 (Pubitemid 43844674)
30. I. Leav, K.M. Lau, J.Y. Adams, J.E. McNeal, M.E. Taplin, and J. Wang Comparative studies of the estrogen receptors beta and alpha and the androgen receptor in normal human prostate glands, dysplasia, and in primary and metastatic carcinoma Am J Pathol 159 2001 79 92 (Pubitemid 33704195)
31. R.D. Mehra, K. Sharma, C. Nyakas, and U. Vij Estrogen receptor alpha and beta immunoreactive neurons in normal adult and aged female rat hippocampus: a qualitative and quantitative study Brain Res 1056 2005 22 35 (Pubitemid 41219354)
32. B.M. Wittmann, A. Sherk, and D.P. McDonnell Definition of functionally important mechanistic differences among selective estrogen receptor down-regulators Cancer Res 67 2007 9549 9560 (Pubitemid 47535946)
33. W.R. Harrington, S. Sheng, D.H. Barnett, L.N. Petz, J.A. Katzenellenbogen, and B.S. Katzenellenbogen Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression Mol Cell Endocrinol 206 2003 13 22 (Pubitemid 37011249)
34. C.Y. Lin, A. Strom, V.B. Vega, S.L. Kong, A.L. Yeo, and J.S. Thomsen Discovery of estrogen receptor alpha target genes and response elements in breast tumor cells Genome Biol 5 2004 R66
35. J. Deschênes, V. Bourdeau, J.H. White, and S. Mader Regulation of GREB1 transcription by estrogen receptor alpha through a multipartite enhancer spread over 20 kb of upstream flanking sequences J Biol Chem 282 2007 17335 17339 (Pubitemid 47100267)
36. G.F. Sewack, and U. Hansen Nucleosome positioning and transcription-associated chromatin alterations on the human estrogen-responsive pS2 promoter J Biol Chem 272 1997 31118 31129 (Pubitemid 27527562)
37. W.J. Welboren, M.A. van Driel, E.M. Janssen-Megens, S.J. van Heeringen, F.C. Sweep, and P.N. Span ChIP-Seq of ERalpha and RNA polymerase II defines genes differentially responding to ligands EMBO J 28 2009 1418 1428
38. C. Garofalo, D. Sisci, and E. Surmacz Leptin interferes with the effects of the antiestrogen ICI182,780 in MCF-7 breast cancer cells Clin Cancer Res 10 2004 6466 6475 (Pubitemid 39346542)
39. Q. Hu, Y.S. Kwon, E. Nunez, M.D. Cardamone, K.R. Hutt, and K.A. Ohgi Enhancing nuclear receptor-induced transcription requires nuclear motor and LSD1-dependent gene networking in interchromatin granules Proc Natl Acad Sci USA 105 2008 19199 19204
40. E.C. Chang, T.H. Charn, S.H. Park, W.G. Helferich, B. Komm, and J.A. Katzenellenbogen Estrogen receptors alpha and beta as determinants of gene expression: influence of ligand, dose and chromatin binding Mol Endocrinol 22 2008 1032 1043 (Pubitemid 351629605)