Interrelationship between myocardial perfusion imaging, coronary calcium score, and endothelial function in asymptomatic diabetics and controls

Journal of Nuclear Cardiology

Volumn 18, Issue 3, 2011, Pages 398-406

  Peix, Amalia ^a   Cabrera, Lázaro Z ^a   Heres, Flor ^b   Rodríguez, Lydia ^c   Valdés, Alexander ^a   Valiente, Juan ^a   Garcí, Raymid ^a   Licea, Manuel ^d   Mendoza, Vladimir ^e   Gárciga, Francisco ^d   Rodríguez, Yaquelin ^a   Carrillo, Regla ^a   Mena, Erick ^a   Fernández, Yoel ^a   Montero, Minerva ^a   Dondi, Maurizio ^f  

^a Institute of Cardiology   (Cuba)

^b Immunology Section   (Cuba)

^c Echocardiography Department   (Cuba)

^d Institute of Endocrinology   (Cuba)

^e Computed Tomography Department ^*  (Cuba)

^f INTERNATIONAL ATOMIC ENERGY AGENCY   (Austria)

Author keywords

Coronary calcium; Diabetes mellitus; Endothelial function; Myocardial scintigraphy; Silent myocardial ischemia

Indexed keywords

CHOLESTEROL; CREATININE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; ARTERY DILATATION; ARTICLE; ASYMPTOMATIC DISEASE; BRACHIAL ARTERY; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CLINICAL EVALUATION; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CORONARY CALCIUM SCORE; CREATININE BLOOD LEVEL; DIABETES MELLITUS; DISEASE DURATION; ECHOGRAPHY; ENDOTHELIAL DYSFUNCTION; FEMALE; HEART MUSCLE PERFUSION; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; ISCHEMIC HEART DISEASE; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; MULTIDETECTOR COMPUTED TOMOGRAPHY; MYOCARDIAL PERFUSION IMAGING; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; SCORING SYSTEM; SILENT MYOCARDIAL ISCHEMIA; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; CALCINOSIS; COMORBIDITY; CORONARY ARTERY DISEASE; CUBA; DIABETES MELLITUS; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; MALE; MYOCARDIAL PERFUSION IMAGING; PREVALENCE; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 79960430597     PISSN: 10713581     EISSN: 15326551     Source Type: Journal    
DOI: 10.1007/s12350-011-9355-2     Document Type: Article

References (41)

1. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes. Estimates for the year 2000 and projections for 2030. Diabetes Care 2004;27:1047-53. (Pubitemid 38579764)
2. Haffner S, Lehto S, Rönemaa T, Pyörälä K, Laakso M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 1998;339:229-34. (Pubitemid 28350165)
3. Third Joint Task Force of European and other Societies on Cardiovascular Disease Prevention in Clinical Practice. European guidelines on cardiovascular disease prevention in clinical practice. Eur J Cardiovasc Prev Rehabil 2003;10:S1-78.
4. National Cholesterol Education Program/Adult Treatment Panel III. Third report of the expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). NIH Publication No. 02-5215, September 2002. http://www.nhlbi.nih.gov/guidelines/cholesterol/atp3-rpt.htm.
5. Wackers F, Young L, Inzuchi S, Chyun D, Davey J, Barrett E, et al. For the Detection of Ischemia in Asymptomatic Diabetics (DIAD) investigators. Detection of silent myocardial ischemia in asymptomatic diabetic subjects: The DIAD study. Diabetes Care 2004;27:1954-61. (Pubitemid 38989238)
6. Rajagopalan N, Miller T, Hodge D, Frye R, Gibbons R. Identifying high-risk asymptomatic diabetic patients who are candidates for screening stress single-photon emission computed tomography imaging. J Am Coll Cardiol 2005;45:43-9. (Pubitemid 40063548)
7. Koistinen M. Prevalence of asymptomatic myocardial ischemia in diabetic subjects. Br Med J 1990;301:92-5. (Pubitemid 20223591)
8. Vanzetto G, Halimi S, Hammond T, Fagret D, Benhamon P, Cordonnier D, et al. Prediction of cardiovascular events in clinically selected high-risk NIDDM patients: Prognostic value of exercise stress test and thallium-201 single-photon emission computed tomography. Diabetes Care 1999;22:19-26. (Pubitemid 29028293)
9. Janand-Delenne B, Savin B, Habib G, Bory M, Vague P, Lassman-Vague V. Silent myocardial ischemia in patients with diabetes. Who to screen? Diabetes Care 1999;22:1396-400. (Pubitemid 29418229)
10. DeLorenzo A, Lima R, Sequeira-Filho A, Pantoja M. Prevalence and prognostic value of perfusion defects detected by stress technetium-99m sestamibi myocardial perfusion single-photon emission computed tomography in asymptomatic patients with diabetes mellitus and no known coronary artery disease. Am J Cardiol 2002;90:827-32.
11. Zellweger M, Hachammovitch R, Kang X, Hayes S, Friedman J, Germano G, et al. Prognostic relevance of symptoms versus objective evidence of coronary artery disease in diabetic patients. Eur Heart J 2004;25:543-50. (Pubitemid 38478546)
12. Miller T, Rajagopalan N, Hodge D, Frye R, Gibbons R. Yield of stress SPECT in asymptomatic patients with diabetes. Am Heart J 2004;147:890-6.
13. Scholte A, Schuijf J, Kharagjitsingh A, Dibbets-Schneider P, Stokkel M, van der Wall E, et al. Prevalence and predictors of an abnormal l stress myocardial perfusion study in asymptomatic patients with type 2 diabetes mellitus. Eur J Nucl Med Mol Imag 2009;36:567-75.
14. Anand D, Lim E, Hopkins D, Corder R, Shaw L, Sharp P, et al. Risk stratification in uncomplicated type 2 diabetes: Prospective evaluation of the combined use of coronary artery calcium imaging and selective myocardial perfusion scintigraphy. Eur Heart J 2006;27:713-21.
15. Corretti M, Anderson T, Benjamin E, et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery. J Am Coll Cardiol 2002;39: 257-65.
16. McVeigh G, Brennan G, Johnston G, McDermott B, McGrath L, Henry W, et al. Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1992;35:771-6.
17. Williams S, Goldfine A, Timimi A. Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo. Circulation 1998;97:1695-701. (Pubitemid 28211418)
18. Kawano H, Motoyama T, Hirashima O, Hirai N, Miyao Y, Ohgushi M. Hyperglycemia rapidly suppresses flow-mediated endothelium-dependent vasodilatation of brachial artery. J Am Coll Cardiol 1999;34:146-54.
19. Cerillo A, Kumar S, Piconi L, Espósito K, Giugliano D. Simultaneous control of hyperglycemia and oxidative stress normalizes endothelial function in type 1 diabetes. Diabetes Care 2007;30: 649-54. (Pubitemid 46357401)
20. Iwasaki K, Matsumoto T, Aono H, Furukawa H, Samukawa M. Prevalence of subclinical atherosclerosis in asymptomatic diabetic patients by 64-slice computed tomography. Coron Artery Dis 2008; 19:195-201. (Pubitemid 351555974)
21. Zeina A, Odeh M, Rosenschein U, Zaid G, Barmeir E. Coronary artery disease among asymptomatic diabetic and nondiabetic patients undergoing coronary computed tomography angiography. Coron Artery Dis 2008;19:37-41. (Pubitemid 351339965)
22. Scholte A, Schuijf J, Kharagjitsingh A, Jukema J, Pundziute G, van der Wall E, et al. Prevalence of coronary artery disease and plaque morphology assessed by multislice computed tomography coronary angiography and calcium scoring in asymptomatic patients with type 2 diabetes. Heart 2008;94:290-5. (Pubitemid 351303418)
23. Raggi P, Shaw L, Berman D, Callister T. Prognostic value of coronary calcium screening in subjects with and without diabetes. J Am Coll Cardiol 2004;43:1663-9. (Pubitemid 38561350)
24. Cerqueira M, Weissman M, Dilsizian V, Jacobs A, Kaul S, Laskey W, et al. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. Circulation 2002;105:539-42.
25. Celermajer D, Sorensen K, Gooch V, Spiegelhalter D, Miller O, Sullivan I. Noninvasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992;340: 1111-5.
26. Garćia-Barreto D, Garćia R, García J, Concepción A, Peix A. Diagnóstico precĺinico de la aterosclerosis: función endotelial. Rev Cubana Med 2003;42:58-63.
27. Bax J, Bonow R, Tschöpe M, Inzuchi S, Barrett E, On behalf of the Global Dialogue Group for the Evaluation of Cardiovascular Risk in Patients with Diabetes. The potential of myocardial per-fusion scintigraphy for risk stratification of asymptomatic patients with type 2 diabetes. J Am Coll Cardiol 2006;48:754-60. (Pubitemid 44175713)
28. Valensi P, Sachs R, Harfouche B, Lormeau B, Paries J, Cosson E, et al. Predictive value of cardiac autonomic neuropathy in diabetic patients with or without silent myocardial ischemia. Diabetes Care 2001;24:339-43. (Pubitemid 32119135)
29. Valensi P, Paries J, Attali J, The French Group for Research and Study of Diabetic Neuropathy. Cardiac autonomic neuropathy in diabetic patients: Influence of diabetes duration, obesity, and the microangiopathic complications: The French Multicenter Study. Metabolism 2003;52:815-20. (Pubitemid 36949541)
30. Nesto R. Screening for asymptomatic coronary artery disease in diabetes (Editorial). Diabetes Care 1999;22:1393-5. (Pubitemid 29418228)
31. Marcus M, Chilian W, Kanatsuka H. Understanding the coronary circulation through studies at the microvascular level. Circulation 1990;82:1-7. (Pubitemid 20216309)
32. Chareonthaitawee P, Sorajja P, Rajagopalan N, Miller T, Hodge D, Frye R, et al. Prevalence and prognosis of left ventricular systolic dysfunction in asymptomatic diabetic patients without known coronary artery disease referred for stress single-photon emission computed tomography and assessment of left ventricular function. Am Heart J 2007;154:567-74. (Pubitemid 47271926)
33. Anderson T, Uehata A, Gerhard M, Meredith I, Knab S, Delag-range D, et al. Close relation of endothelial function in the human coronary and peripheral circulations. J Am Coll Cardiol 1995;26: 1235-41.
34. Kuvin J, Patel A, Sliney K, Pandian N, Rand W, Udelson J, et al. Peripheral vascular endothelial function testing as a noninvasive indicator of coronary artery disease. J Am Coll Cardiol 2001;38: 1843-9. (Pubitemid 33116553)
35. Pellegrino T, Storto G, Perrone Filardi P, Sorrentino A, Silvestro A, Petretta M, et al. Relationship between brachial artery flow-mediated dilation and coronary flow reserve in patients with peripheral artery disease. J Nucl Med 2005;46:1997-2002. (Pubitemid 46657445)
36. Masci P, Lacaustra M, Lara J, Kaski J. Brachial artery flow-mediated dilation and myocardial perfusion in patients with cardiac syndrome X. Am J Cardiol 2005;95:1478-80. (Pubitemid 40824774)
37. Zeiher A, Krause T, Schachinger V, Minners J, Moser E. Impaired endothelium-dependent vasodilation of coronary resistance vessels is associated with exercise-induced myocardial ischemia. Circulation 1995;91:2345-52.
38. Schindler T, Nitzsche E, Magosaki N, Brink I, Mix M, Olschewski M, et al. Regional myocardial perfusion defects during exercise, as assessed by three dimensional integration of morphology and function, in relation to abnormal endothelium dependent vasore-activity of the coronary microcirculation. Heart 2003;89:517-26. (Pubitemid 36520801)
39. Hasdai D, Gibbons R, Holmes D, Higano S, Lerman A. Coronary endothelial dysfunction in humans is associated with myocardial perfusion defects. Circulation 1997;96:3390-5. (Pubitemid 27513410)
40. Papaioannu G, Kasapis C, Seip R, Grey N, Katten D, Wackers F, et al. Value of peripheral vascular endothelial function in the detection of relative myocardial ischemia in asymptomatic type 2 diabetic patients who underwent myocardial perfusion imaging. J Nucl Cardiol 2006;13:362-8. (Pubitemid 43792987)
41. Yerramasu A, Lahiri A, Chua T. Comparative roles of cardiac CT and myocardial perfusion scintigraphy in the evaluation of patients with coronary artery disease: Competitive or complementary. J Nucl Cardiol 2010;17:761-70.