Lyophilized plasma reconstituted with ascorbic acid suppresses inflammation and oxidative DNA damage

Journal of Trauma - Injury, Infection and Critical Care

Volumn 71, Issue 1, 2011, Pages 20-25

  Van, Philbert Y ^a   Hamilton, Gregory J ^a   Kremenevskiy, Igor V ^a   Sambasivan, Chitra ^a   Spoerke, Nicholas J ^a   Differding, Jerome A ^a   Watters, Jennifer M ^a   Schreiber, Martin A ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Ascorbic acid; Inflammation; Lyophilized plasma; Oxidative DNA damage

Indexed keywords

ASCORBIC ACID; CITRIC ACID; CYTOKINE; HYDROCHLORIC ACID; INTERLEUKIN 6;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING; CONTROLLED STUDY; DNA DAMAGE; ENZYME LINKED IMMUNOSORBENT ASSAY; HEMORRHAGIC SHOCK; INFLAMMATION; LYOPHILISATE; MULTIPLE TRAUMA; NONHUMAN; OXIDATIVE STRESS; PLASMA; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; CYTOKINES; DISEASE MODELS, ANIMAL; DNA DAMAGE; ENZYME-LINKED IMMUNOSORBENT ASSAY; INFLAMMATION; MULTIPLE TRAUMA; OXIDATIVE STRESS; PLASMA; RESUSCITATION; SHOCK, HEMORRHAGIC; SWINE; TREATMENT OUTCOME;

EID: 79960428349     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e3182214f44     Document Type: Article

References (11)

1. Cotton BA, Au BK, Nunez TC, Gunter OL, Robertson AM, Young PP. Predefined massive transfusion protocols are associated with a reduction in organ failure and postinjury complications. J Trauma. 2009;66: 41-48.
2. Holcomb JB, Wade CE, Michalek JE, et al. Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients. Ann Surg. 2008;248:447-458.
3. Borgman MA, Spinella PC, Perkins JG, et al. The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. J Trauma. 2007;63:805-813. (Pubitemid 350287298)
4. Spoerke NJ, Zink KA, Cho SD, et al. Lyophilized plasma for resuscitation in a swine model of severe injury. Arch Surg. 2009; 144:829-834.
5. Cho SD, Holcomb JB, Tieu BH, et al. Reproducibility of an animal model simulating complex combat-related injury in a multiple-institution format. Shock. 2009;31:87-96.
6. Valavanidis A, Vlachogianni T, Fiotakis C. 8-hydroxy-2′- deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009;27:120-139.
7. Schwager J, Schulze J. Modulation of interleukin production by ascorbic acid. Vet Immunol Immunopathol. 1998;64:45-57. (Pubitemid 28446294)
8. Schwager J, Schulze J. Influence of ascorbic acid on the response to mitogens and interleukin production of porcine lymphocytes. Int J Vitam Nutr Res. 1997;67:10-16. (Pubitemid 27108736)
9. Härtel C, Strunk T, Bucsky P, Schultz C. Effects of vitamin C on intracytoplasmic cytokine production in human whole blood monocytes and lymphocytes. Cytokine. 2004;27:101-106. (Pubitemid 38950980)
10. Bowie AG, O?Neill LA. Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase. J Immunol. 2000;165:7180-7188. (Pubitemid 32001195)
11. Tomofuji T, Ekuni D, Sanbe T, et al. Effects of vitamin C intake on gingival oxidative stress in rat periodontitis. Free Radic Biol Med. 2009;46:163-168.