Synthesis of 1,4-dihydropyridine using microwave-assisted aza-Diels-Alder reaction and its application to Amlodipine

Journal of Industrial and Engineering Chemistry

Volumn 17, Issue 3, 2011, Pages 401-403

  Lee, Youn A ^a   Kim, Seok Chan ^a  

^a Kookmin University   (South Korea)

Author keywords

1,4 Dihydropyridine; Amlodipine; Aza Diels Alder reaction; Microwave assisted reaction

Indexed keywords

1 ,4-DIHYDROPYRIDINE; AMLODIPINE; ANTIHYPERTENSIVE DRUGS; AZA-DIELS-ALDER REACTION; MICROWAVE-ASSISTED; MICROWAVE-ASSISTED REACTION; ORGANIC MOLECULES; RAPID SYNTHESIS; REACTION UNDER;

MICROWAVE IRRADIATION; PYRIDINE;

SYNTHESIS (CHEMICAL);

EID: 79960424318     PISSN: 1226086X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jiec.2011.02.031     Document Type: Article

References (12)

1. Triggle D.J., Lang D.A., Janis R.A. Med. Res. Rev. 1989, 9:123.
2. Goldmann S., Stoltefuss J. Angew. Chem. Int. Ed. Engl. 1991, 30:1559.
3. Siva Lakshmi Devi A., Srinivasa Rao Y., Satish M., Jyothi G., Babu Rao K., Omdutt T. Magn. Reson. Chem. 2007, 45:688.
4. Gotrane D., Deshmukh R., Ranade P., Sonawane S., Bhawal B., Gharpure M., Gurjar M. Org. Process Res. Dev. 2010, 14:640.
5. Häntzsch A. Justus Liebigs Ann. Chem. 1882, 215:1.
6. Alajarin R., Vaquero J.J., Garcia Navio J.L., Alvarez-Builla J. Synlett 1992, 297.
7. Khadilkar B.M., Gaikar V.G., Chitnavis A.A. Tetrahedron Lett. 1995, 36:8083.
8. Khadilkar B.M., Chitnavis A.A. Indian J. Chem. Sect. B 1995, 34:652.
9. Öhberg L., Westman J. Synlett 2001, 1293.
10. Kim S., Choi K., Cheong C. Bull. Korean Chem. Soc. 2002, 23:143.
11. S.F. Campbell, US. Patent 4,572,909 (1986).
12. Sircar L., Anderson K.R. Tetrahedron Lett. 1988, 29:6835.