Systemic Par-4 inhibits non-autochthonous tumor growth

Cancer Biology and Therapy

Volumn 12, Issue 2, 2011, Pages 152-157

  Zhao, Yanming ^a   Burikhanov, Ravshan ^a   Brandon, Jason ^a   Qiu, Shirley ^a   Shelton, Brent J ^a,b,c   Spear, Brett ^b,c   Bondada, Subbarao ^b,c   Bryson, Scott ^a,b,c   Rangnekar, Vivek M ^a,b,c  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Metastasis; Par 4; Systemic protein

Indexed keywords

GLUCOSE REGULATED PROTEIN 78; PROTEINASE ACTIVATED RECEPTOR 4; SACCHAROMYCES CEREVISIAE PROTEIN;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL; CANCER RESISTANCE; CANCER SUSCEPTIBILITY; CELL SURFACE; METASTASIS; MOUSE; NONHUMAN; PROSTATE CANCER; TRANSGENIC MOUSE; TUMOR GROWTH;

3T3 CELLS; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BONE MARROW TRANSPLANTATION; CELL LINE, TUMOR; GENES, TUMOR SUPPRESSOR; MICE; MICE, INBRED C3H; MICE, TRANSGENIC; NEOPLASMS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; TRANSPLANTATION, HETEROLOGOUS; TUMOR SUPPRESSOR PROTEINS;

EID: 79960408944     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.12.2.15734     Document Type: Article

References (12)

1. Cooperberg MR, Broering JM, Carroll PR. Risk assessment for prostate cancer metastasis and mortality at the time of diagnosis. J Natl Cancer Inst 2009; 101:878-87.
2. Eschwège P, Moutereau S, Droupy S, Douard R, Gala JL, Benoit G, et al. Prognostic value of prostate circulating cells detection in prostate cancer patients: a prospective study. Br J Cancer 2009; 100:608-10.
3. Sells SF, Wood DP Jr, Joshi-Barve SS, Muthukumar S, Jacob RJ, Crist SA, et al. Commonality of the gene programs induced by effectors of apoptosis in androgen-dependent and -independent prostate cells. Cell Growth Differ 1994; 5:457-66. (Pubitemid 24251397)
4. Shrestha-Bhattarai T, Rangnekar VM. Cancer-selective apoptotic effects of extracellular and intracellular Par-4. Oncogene 2010; 29:3873-80.
5. Garcia-Cao I, Duran A, Collado M, Diaz-Meco MT, Serrano M, Moscat J. Tumor-suppression activity of the proapoptotic regulator Par4. EMBO Rep 2003;6:577-83.
6. Cook J, Krishnan S, Ananth S, Sells SF, Shi Y, Walther MM, et al. Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma. Oncogene 1999;18:1205-8. (Pubitemid 29085993)
7. Moreno-Bueno G, Fernandez-Marcos PJ, Collado M, Tendero MJ, Rodriguez-Pinilla SM, Garcia-Cao I, et al. Inactivation of the candidate tumor suppressor par-4 in endometrial cancer. Cancer Res 2007; 67:1927-34. (Pubitemid 46424208)
8. Goswami A, Burikhanov R, de Thonel A, Fujita N, Goswami M, Zhao Y, et al. Binding and phosphorylation of par-4 by akt is essential for cancer cell survival. Mol Cell 2005; 20:33-44. (Pubitemid 41396560)
9. El-Guendy N, Zhao Y, Gurumurthy S, Burikhanov R, Rangnekar VM. Identification of a unique core domain of par-4 sufficient for selective apoptosis induction in cancer cells. Mol Cell Biol 2003; 23:5516-25. (Pubitemid 36951320)
10. El-Guendy N, Rangnekar VM. Apoptosis by Par-4 in cancer and neurodegenerative diseases. Exp Cell Res 2003; 283:51-66. (Pubitemid 36259895)
11. Burikhanov R, Zhao Y, Goswami A, Qiu S, Schwarze SR, Rangnekar VM. The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis. Cell 2009;138:377-88.
12. Zhao Y, Burikhanov R, Qiu S, Lele SM, Jennings CD, Bondada S, et al. Cancer resistance in transgenic mice expressing the SAC module of Par-4. Cancer Res 2007;67:9276-85. (Pubitemid 47535916)