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Volumn 41, Issue 8, 2011, Pages 1143-1156

Bacillus-derived poly-γ-glutamic acid attenuates allergic airway inflammation through a Toll-like receptor-4-dependent pathway in a murine model of asthma

Author keywords

Airway inflammation; Asthma; Dendritic cells; Poly glutamic acid; Th2 responses; Toll like receptor 4

Indexed keywords

ALLERGEN; BETA ACTIN; CD40 ANTIGEN; CD86 ANTIGEN; CYTOKINE; GLUTAMIC ACID DERIVATIVE; I KAPPA B ALPHA; IMMUNOGLOBULIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; OVALBUMIN; POLY GAMMA GLUTAMIC ACID; RANTES; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

EID: 79960406080     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2011.03792.x     Document Type: Article
Times cited : (26)

References (51)
  • 1
    • 33746294223 scopus 로고    scopus 로고
    • The global burden of asthma
    • Braman SS. The global burden of asthma. Chest 2006; 130:4S-12S.
    • (2006) Chest , vol.130
    • Braman, S.S.1
  • 3
    • 36148933015 scopus 로고    scopus 로고
    • Pharmacotherapy of asthma
    • Zdanowicz MM. Pharmacotherapy of asthma. Am J Pharm Educ 2007; 71:98.
    • (2007) Am J Pharm Educ , vol.71 , pp. 98
    • Zdanowicz, M.M.1
  • 6
    • 0024353079 scopus 로고
    • TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties
    • Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989; 7:145-73.
    • (1989) Annu Rev Immunol , vol.7 , pp. 145-173
    • Mosmann, T.R.1    Coffman, R.L.2
  • 7
    • 0028931102 scopus 로고
    • CpG motifs in bacterial DNA trigger direct B-cell activation
    • Krieg AM, Yi AK, Matson S et al. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 1995; 374:546-9.
    • (1995) Nature , vol.374 , pp. 546-549
    • Krieg, A.M.1    Yi, A.K.2    Matson, S.3
  • 8
    • 0029984358 scopus 로고    scopus 로고
    • CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma
    • Klinman DM, Yi AK, Beaucage SL, Conover J, Krieg AM. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. Proc Natl Acad Sci USA 1996; 93:2879-83.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 2879-2883
    • Klinman, D.M.1    Yi, A.K.2    Beaucage, S.L.3    Conover, J.4    Krieg, A.M.5
  • 9
    • 0032521274 scopus 로고    scopus 로고
    • Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma
    • Kline JN, Waldschmidt TJ, Businga TR et al. Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma. J Immunol 1998; 160:2555-9.
    • (1998) J Immunol , vol.160 , pp. 2555-2559
    • Kline, J.N.1    Waldschmidt, T.J.2    Businga, T.R.3
  • 10
    • 0033485399 scopus 로고    scopus 로고
    • Phosphorothioate oligodeoxynucleotides promote the in vitro development of human allergen-specific CD4+ T cells into Th1 effectors
    • Parronchi P, Brugnolo F, Annunziato F et al. Phosphorothioate oligodeoxynucleotides promote the in vitro development of human allergen-specific CD4+ T cells into Th1 effectors. J Immunol 1999; 163:5946-53.
    • (1999) J Immunol , vol.163 , pp. 5946-5953
    • Parronchi, P.1    Brugnolo, F.2    Annunziato, F.3
  • 12
    • 34247135082 scopus 로고    scopus 로고
    • Airway exposure levels of lipopolysaccharide determine type 1 versus type 2 experimental asthma
    • Kim YK, Oh SY, Jeon SG et al. Airway exposure levels of lipopolysaccharide determine type 1 versus type 2 experimental asthma. J Immunol 2007; 178:5375-82.
    • (2007) J Immunol , vol.178 , pp. 5375-5382
    • Kim, Y.K.1    Oh, S.Y.2    Jeon, S.G.3
  • 13
    • 0037121946 scopus 로고    scopus 로고
    • Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen
    • Eisenbarth SC, Piggott DA, Huleatt JW, Visintin I, Herrick CA, Bottomly K. Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J Exp Med 2002; 196:1645-51.
    • (2002) J Exp Med , vol.196 , pp. 1645-1651
    • Eisenbarth, S.C.1    Piggott, D.A.2    Huleatt, J.W.3    Visintin, I.4    Herrick, C.A.5    Bottomly, K.6
  • 14
    • 65349134226 scopus 로고    scopus 로고
    • Dendritic cell homeostasis
    • Merad M, Manz MG. Dendritic cell homeostasis. Blood 2009; 113:3418-27.
    • (2009) Blood , vol.113 , pp. 3418-3427
    • Merad, M.1    Manz, M.G.2
  • 15
    • 0035202483 scopus 로고    scopus 로고
    • Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology
    • Asselin-Paturel C, Boonstra A, Dalod M et al. Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology. Nat Immunol 2001; 2:1144-50.
    • (2001) Nat Immunol , vol.2 , pp. 1144-1150
    • Asselin-Paturel, C.1    Boonstra, A.2    Dalod, M.3
  • 16
    • 3142720367 scopus 로고    scopus 로고
    • Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen
    • de Heer HJ, Hammad H, Soullie T et al. Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen. J Exp Med 2004; 200:89-98.
    • (2004) J Exp Med , vol.200 , pp. 89-98
    • de Heer, H.J.1    Hammad, H.2    Soullie, T.3
  • 17
    • 55849140547 scopus 로고    scopus 로고
    • HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase-dependent mechanism
    • Manches O, Munn D, Fallahi A et al. HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2, 3-dioxygenase-dependent mechanism. J Clin Invest 2008; 118:3431-9.
    • (2008) J Clin Invest , vol.118 , pp. 3431-3439
    • Manches, O.1    Munn, D.2    Fallahi, A.3
  • 18
    • 63449130201 scopus 로고    scopus 로고
    • Fms-like tyrosine kinase 3 ligand increases a lung DC subset with regulatory properties in allergic airway inflammation
    • Shao Z, Bharadwaj AS, McGee HS, Makinde TO, Agrawal DK. Fms-like tyrosine kinase 3 ligand increases a lung DC subset with regulatory properties in allergic airway inflammation. J Allergy Clin Immunol 2009; 123:917-24.
    • (2009) J Allergy Clin Immunol , vol.123 , pp. 917-924
    • Shao, Z.1    Bharadwaj, A.S.2    McGee, H.S.3    Makinde, T.O.4    Agrawal, D.K.5
  • 19
    • 73349116588 scopus 로고    scopus 로고
    • Fms-like tyrosine kinase 3 ligand regulates migratory pattern and antigen uptake of lung dendritic cell subsets in a murine model of allergic airway inflammation
    • Shao Z, Makinde TO, McGee HS, Wang X, Agrawal DK. Fms-like tyrosine kinase 3 ligand regulates migratory pattern and antigen uptake of lung dendritic cell subsets in a murine model of allergic airway inflammation. J Immunol 2009; 183:7531-8.
    • (2009) J Immunol , vol.183 , pp. 7531-7538
    • Shao, Z.1    Makinde, T.O.2    McGee, H.S.3    Wang, X.4    Agrawal, D.K.5
  • 20
    • 33645513746 scopus 로고    scopus 로고
    • Natural and edible biopolymer poly-gamma-glutamic acid: synthesis, production, and applications
    • Sung MH, Park C, Kim CJ, Poo H, Soda K, Ashiuchi M. Natural and edible biopolymer poly-gamma-glutamic acid: synthesis, production, and applications. Chem Rec 2005; 5:352-66.
    • (2005) Chem Rec , vol.5 , pp. 352-366
    • Sung, M.H.1    Park, C.2    Kim, C.J.3    Poo, H.4    Soda, K.5    Ashiuchi, M.6
  • 21
    • 70349486977 scopus 로고    scopus 로고
    • Bacillus subtilis-specific poly-gamma-glutamic acid regulates development pathways of naive CD4(+) T cells through antigen-presenting cell-dependent and -independent mechanisms
    • Kim S, Yang JY, Lee K et al. Bacillus subtilis-specific poly-gamma-glutamic acid regulates development pathways of naive CD4(+) T cells through antigen-presenting cell-dependent and -independent mechanisms. Int Immunol 2009; 21:977-90.
    • (2009) Int Immunol , vol.21 , pp. 977-990
    • Kim, S.1    Yang, J.Y.2    Lee, K.3
  • 22
    • 65249180981 scopus 로고    scopus 로고
    • A positive feedback loop of IL-21 signaling provoked by homeostatic CD4+CD25- T cell expansion is essential for the development of arthritis in autoimmune K/BxN mice
    • Jang E, Cho SH, Park H, Paik DJ, Kim JM, Youn J. A positive feedback loop of IL-21 signaling provoked by homeostatic CD4+CD25- T cell expansion is essential for the development of arthritis in autoimmune K/BxN mice. J Immunol 2009; 182:4649-56.
    • (2009) J Immunol , vol.182 , pp. 4649-4656
    • Jang, E.1    Cho, S.H.2    Park, H.3    Paik, D.J.4    Kim, J.M.5    Youn, J.6
  • 24
    • 60849122545 scopus 로고    scopus 로고
    • Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma
    • Zhang Z, Hener P, Frossard N et al. Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma. Proc Natl Acad Sci USA 2009; 106:1536-41.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 1536-1541
    • Zhang, Z.1    Hener, P.2    Frossard, N.3
  • 25
    • 0028970060 scopus 로고
    • Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
    • Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 1995; 13:251-76.
    • (1995) Annu Rev Immunol , vol.13 , pp. 251-276
    • Trinchieri, G.1
  • 27
    • 0031058726 scopus 로고    scopus 로고
    • Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells
    • Rincon M, Anguita J, Nakamura T, Fikrig E, Flavell RA. Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells. J Exp Med 1997; 185:461-9.
    • (1997) J Exp Med , vol.185 , pp. 461-469
    • Rincon, M.1    Anguita, J.2    Nakamura, T.3    Fikrig, E.4    Flavell, R.A.5
  • 28
    • 0037408497 scopus 로고    scopus 로고
    • IL-6 production by pulmonary dendritic cells impedes Th1 immune responses
    • Dodge IL, Carr MW, Cernadas M, Brenner MB. IL-6 production by pulmonary dendritic cells impedes Th1 immune responses. J Immunol 2003; 170:4457-64.
    • (2003) J Immunol , vol.170 , pp. 4457-4464
    • Dodge, I.L.1    Carr, M.W.2    Cernadas, M.3    Brenner, M.B.4
  • 29
    • 0037114134 scopus 로고    scopus 로고
    • Murine plasmacytoid pre-dendritic cells generated from Flt3 ligand-supplemented bone marrow cultures are immature APCs
    • Brawand P, Fitzpatrick DR, Greenfield BW, Brasel K, Maliszewski CR, De Smedt T. Murine plasmacytoid pre-dendritic cells generated from Flt3 ligand-supplemented bone marrow cultures are immature APCs. J Immunol 2002; 169:6711-9.
    • (2002) J Immunol , vol.169 , pp. 6711-6719
    • Brawand, P.1    Fitzpatrick, D.R.2    Greenfield, B.W.3    Brasel, K.4    Maliszewski, C.R.5    De Smedt, T.6
  • 30
    • 0035177431 scopus 로고    scopus 로고
    • Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes
    • Vermaelen KY, Carro-Muino I, Lambrecht BN, Pauwels RA. Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes. J Exp Med 2001; 193:51-60.
    • (2001) J Exp Med , vol.193 , pp. 51-60
    • Vermaelen, K.Y.1    Carro-Muino, I.2    Lambrecht, B.N.3    Pauwels, R.A.4
  • 31
    • 0037177825 scopus 로고    scopus 로고
    • Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4
    • Asea A, Rehli M, Kabingu E et al. Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J Biol Chem 2002; 277:15028-34.
    • (2002) J Biol Chem , vol.277 , pp. 15028-15034
    • Asea, A.1    Rehli, M.2    Kabingu, E.3
  • 32
    • 79951476391 scopus 로고    scopus 로고
    • Novel interactions of a microbial superantigen with TLR2 and TLR4 differentially regulate IL-17 and Th17-associated cytokines
    • Mu HH, Hasebe A, Van Schelt A, Cole BC. Novel interactions of a microbial superantigen with TLR2 and TLR4 differentially regulate IL-17 and Th17-associated cytokines. Cell Microbiol 2011; 13:374-87.
    • (2011) Cell Microbiol , vol.13 , pp. 374-387
    • Mu, H.H.1    Hasebe, A.2    Van Schelt, A.3    Cole, B.C.4
  • 33
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
    • Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 2010; 11:373-84.
    • (2010) Nat Immunol , vol.11 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 34
    • 0032760049 scopus 로고    scopus 로고
    • Molecular basis for selective eosinophil trafficking in asthma: a multistep paradigm
    • Wardlaw AJ. Molecular basis for selective eosinophil trafficking in asthma: a multistep paradigm. J Allergy Clin Immunol 1999; 104:917-26.
    • (1999) J Allergy Clin Immunol , vol.104 , pp. 917-926
    • Wardlaw, A.J.1
  • 35
    • 9644281044 scopus 로고    scopus 로고
    • Interleukin-13 in asthma pathogenesis
    • Wills-Karp M. Interleukin-13 in asthma pathogenesis. Immunol Rev 2004; 202:175-90.
    • (2004) Immunol Rev , vol.202 , pp. 175-190
    • Wills-Karp, M.1
  • 36
    • 0034774796 scopus 로고    scopus 로고
    • Early interleukin 4-dependent response can induce airway hyperreactivity before development of airway inflammation in a mouse model of asthma
    • To Y, Dohi M, Tanaka R, Sato A, Nakagome K, Yamamoto K. Early interleukin 4-dependent response can induce airway hyperreactivity before development of airway inflammation in a mouse model of asthma. Lab Invest 2001; 81:1385-96.
    • (2001) Lab Invest , vol.81 , pp. 1385-1396
    • To, Y.1    Dohi, M.2    Tanaka, R.3    Sato, A.4    Nakagome, K.5    Yamamoto, K.6
  • 37
    • 34548759204 scopus 로고    scopus 로고
    • Oral administration of high molecular mass poly-gamma-glutamate induces NK cell-mediated antitumor immunity
    • Kim TW, Lee TY, Bae HC et al. Oral administration of high molecular mass poly-gamma-glutamate induces NK cell-mediated antitumor immunity. J Immunol 2007; 179:775-80.
    • (2007) J Immunol , vol.179 , pp. 775-780
    • Kim, T.W.1    Lee, T.Y.2    Bae, H.C.3
  • 38
    • 70349778938 scopus 로고    scopus 로고
    • Oral administration of poly-gamma-glutamate induces TLR4- and dendritic cell-dependent antitumor effect
    • Lee TY, Kim YH, Yoon SW et al. Oral administration of poly-gamma-glutamate induces TLR4- and dendritic cell-dependent antitumor effect. Cancer Immunol Immunother 2009; 58:1781-94.
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 1781-1794
    • Lee, T.Y.1    Kim, Y.H.2    Yoon, S.W.3
  • 39
    • 20244384395 scopus 로고    scopus 로고
    • Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression
    • Nomura F, Akashi S, Sakao Y et al. Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression. J Immunol 2000; 164:3476-9.
    • (2000) J Immunol , vol.164 , pp. 3476-3479
    • Nomura, F.1    Akashi, S.2    Sakao, Y.3
  • 40
    • 77953609056 scopus 로고    scopus 로고
    • Dose-dependent effects of erythropoietin in propofol anesthetized neonatal rats
    • Zacharias R, Schmidt M, Kny J et al. Dose-dependent effects of erythropoietin in propofol anesthetized neonatal rats. Brain Res 2010; 1343:14-9.
    • (2010) Brain Res , vol.1343 , pp. 14-19
    • Zacharias, R.1    Schmidt, M.2    Kny, J.3
  • 41
    • 39449095721 scopus 로고    scopus 로고
    • Synergistic damage of tumor vessels with ultra low-dose endothelial-monocyte activating polypeptide-II and neovasculature-targeted tumor necrosis factor-alpha
    • Crippa L, Gasparri A, Sacchi A, Ferrero E, Curnis F, Corti A. Synergistic damage of tumor vessels with ultra low-dose endothelial-monocyte activating polypeptide-II and neovasculature-targeted tumor necrosis factor-alpha. Cancer Res 2008; 68:1154-61.
    • (2008) Cancer Res , vol.68 , pp. 1154-1161
    • Crippa, L.1    Gasparri, A.2    Sacchi, A.3    Ferrero, E.4    Curnis, F.5    Corti, A.6
  • 42
    • 36749065556 scopus 로고    scopus 로고
    • A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma
    • Flood-Page P, Swenson C, Faiferman I et al. A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma. Am J Respir Crit Care Med 2007; 176:1062-71.
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 1062-1071
    • Flood-Page, P.1    Swenson, C.2    Faiferman, I.3
  • 43
    • 0037438409 scopus 로고    scopus 로고
    • Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway
    • Flood-Page PT, Menzies-Gow AN, Kay AB, Robinson DS. Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway. Am J Respir Crit Care Med 2003; 167:199-204.
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 199-204
    • Flood-Page, P.T.1    Menzies-Gow, A.N.2    Kay, A.B.3    Robinson, D.S.4
  • 44
    • 6644229440 scopus 로고    scopus 로고
    • Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
    • Leckie MJ, ten Brinke A, Khan J et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 2000; 356:2144-8.
    • (2000) Lancet , vol.356 , pp. 2144-2148
    • Leckie, M.J.1    ten Brinke, A.2    Khan, J.3
  • 45
    • 61849086181 scopus 로고    scopus 로고
    • Mepolizumab and exacerbations of refractory eosinophilic asthma
    • Haldar P, Brightling CE, Hargadon B et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 2009; 360:973-84.
    • (2009) N Engl J Med , vol.360 , pp. 973-984
    • Haldar, P.1    Brightling, C.E.2    Hargadon, B.3
  • 46
    • 61849155730 scopus 로고    scopus 로고
    • Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
    • Nair P, Pizzichini MM, Kjarsgaard M et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med 2009; 360:985-93.
    • (2009) N Engl J Med , vol.360 , pp. 985-993
    • Nair, P.1    Pizzichini, M.M.2    Kjarsgaard, M.3
  • 47
    • 55849148482 scopus 로고    scopus 로고
    • The cytokine network in asthma and chronic obstructive pulmonary disease
    • Barnes PJ. The cytokine network in asthma and chronic obstructive pulmonary disease. J Clin Invest 2008; 118:3546-56.
    • (2008) J Clin Invest , vol.118 , pp. 3546-3556
    • Barnes, P.J.1
  • 48
    • 35348909044 scopus 로고    scopus 로고
    • Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients
    • Lancet
    • Wenzel S, Wilbraham D, Fuller R, Getz EB, Longphre M. Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies. Lancet 2007; 370:1422-31.
    • (2007) results of two phase 2a studies , vol.370 , pp. 1422-1431
    • Wenzel, S.1    Wilbraham, D.2    Fuller, R.3    Getz, E.B.4    Longphre, M.5
  • 49
    • 0343953087 scopus 로고    scopus 로고
    • Conjugation of immunostimulatory DNA to the short ragweed allergen amb a 1 enhances its immunogenicity and reduces its allergenicity
    • Tighe H, Takabayashi K, Schwartz D et al. Conjugation of immunostimulatory DNA to the short ragweed allergen amb a 1 enhances its immunogenicity and reduces its allergenicity. J Allergy Clin Immunol 2000; 106:124-34.
    • (2000) J Allergy Clin Immunol , vol.106 , pp. 124-134
    • Tighe, H.1    Takabayashi, K.2    Schwartz, D.3
  • 50
    • 17844371968 scopus 로고    scopus 로고
    • Immunostimulatory sequence DNA linked to the Amb a 1 allergen promotes T(H)1 cytokine expression while downregulating T(H)2 cytokine expression in PBMCs from human patients with ragweed allergy
    • Marshall JD, Abtahi S, Eiden JJ et al. Immunostimulatory sequence DNA linked to the Amb a 1 allergen promotes T(H)1 cytokine expression while downregulating T(H)2 cytokine expression in PBMCs from human patients with ragweed allergy. J Allergy Clin Immunol 2001; 108:191-7.
    • (2001) J Allergy Clin Immunol , vol.108 , pp. 191-197
    • Marshall, J.D.1    Abtahi, S.2    Eiden, J.J.3
  • 51
    • 33749436870 scopus 로고    scopus 로고
    • Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis
    • Creticos PS, Schroeder JT, Hamilton RG et al. Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis. N Engl J Med 2006; 355:1445-55.
    • (2006) N Engl J Med , vol.355 , pp. 1445-1455
    • Creticos, P.S.1    Schroeder, J.T.2    Hamilton, R.G.3


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