Induction of G 2/M arrest and apoptosis by sulforaphane in human osteosarcoma U2-OS cells

Molecular Medicine Reports

Volumn 4, Issue 5, 2011, Pages 929-934

  Kim, Mi Ran ^a   Zhou, Lu ^a   Park, Byung Hyun ^a   Kim, Jung Ryul ^a  

^a Chonbuk National University   (South Korea)

Author keywords

Apoptosis; Cell cycle; Osteosarcoma; Sulforaphane; U2 OS

Indexed keywords

CYCLIN A; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; LIPOCORTIN 5; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROPIDIUM IODIDE; PROTEIN P21; SULFORAPHANE; APOPTOSIS REGULATORY PROTEIN; CASPASE ACTIVATED DNASE INHIBITOR; CASPASE-ACTIVATED DNASE INHIBITOR; CELL CYCLE PROTEIN; SULFORAFAN; THIOCYANIC ACID DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG EFFECT; DRUG MECHANISM; HUMAN; HUMAN CELL; OSTEOSARCOMA; OSTEOSARCOMA CELL; PROTEIN EXPRESSION; UPREGULATION; DRUG SCREENING; FLOW CYTOMETRY; METABOLISM; MITOSIS; PATHOLOGY; PROTEIN PROCESSING; TIME; TUMOR CELL LINE;

BRASSICA OLERACEA VAR. ITALICA;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; FLOW CYTOMETRY; G2 PHASE; HUMANS; MITOSIS; OSTEOSARCOMA; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; THIOCYANATES; TIME FACTORS;

EID: 79960400916     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2011.520     Document Type: Article

References (27)

1. Hartwell LH and Kastan MB: Cell cycle control and cancer. Science 266: 1821-1828, 1994.
2. Jackman M, Lindon C, Nigg EA and Pines J: Active cyclin B1-Cdk1 first appears on centrosomes in prophase. Nat Cell Biol 5: 143-148, 2003. (Pubitemid 36204196)
3. Jin P, Hardy S and Morgan DO: Nuclear localization of cyclin B1 controls mitotic entry after DNA damage. J Cell Biol 141: 875-885, 1998. (Pubitemid 28243956)
4. Morgan DO: Principles of CDK regulation. Nature 374: 131-134, 1995.
5. Martinez JD, Stratagoules ED, LaRue JM, et al: Different bile acids exhibit distinct biological effects: the tumor promoter deoxycholic acid induces apoptosis and the chemopreventive agent ursodeoxycholic acid inhibits cell proliferation. Nutr Cancer 31: 111-118, 1998. (Pubitemid 28428071)
6. Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R and Beach D: p21 is a universal inhibitor of cyclin kinases. Nature 366: 701-704, 1993. (Pubitemid 24036020)
7. Kwon KB, Park BH and Ryu DG: Chemotherapy through mitochondrial apoptosis using nutritional supplements and herbs: a brief overview. J Bioenerg Biomembr 39: 31-34, 2007.
8. Wyllie AH, Kerr JF and Currie AR: Cell death: the significance of apoptosis. Int Rev Cytol 68: 251-306, 1980. (Pubitemid 11219226)
9. Fesik SW: Promoting apoptosis as a strategy for cancer drug discovery. Nat Rev Cancer 5: 876-885, 2005.
10. Kurokawa M and Kornbluth S: Caspases and kinases in a death grip. Cell 138: 838-854, 2009.
11. Zhang Y, Talalay P, Cho CG and Posner GH: A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc Natl Acad Sci USA 89: 2399-2403, 1992.
12. Yoon HY, Kang NI, Lee HK, Jang KY, Park JW and Park BH: Sulforaphane protects kidneys against ischemia-reperfusion injury through induction of the Nrf2-dependent phase 2 enzyme. Biochem Pharmacol 75: 2214-2223, 2008.
13. Song MY, Kim EK, Moon WS, et al: Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway. Toxicol Appl Pharmacol 235: 57-67, 2009.
14. Antosiewicz J, Ziolkowski W, Kar S, Powolny AA and Singh SV: Role of reactive oxygen intermediates in cellular responses to dietary cancer chemopreventive agents. Planta Med 74: 1570-1579, 2008.
15. Dashwood RH and Ho E: Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanates. Nutr Rev 66 (Suppl 1): 36-38, 2008.
16. Matsui TA, Murata H, Sakabe T, et al: Sulforaphane induces cell cycle arrest and apoptosis in murine osteosarcoma cells in vitro and inhibits tumor growth in vivo. Oncol Rep 18: 1263-1268, 2007.
17. Matsui TA, Sowa Y, Yoshida T, et al: Sulforaphane enhances TRAIL-induced apoptosis through the induction of DR5 expression in human osteosarcoma cells. Carcinogenesis 27: 1768-1777, 2006. (Pubitemid 44288659)
18. Jacks T and Weinberg RA: Cell-cycle control and its watchman. Nature 381: 643-644, 1996. (Pubitemid 26196558)
19. Shapiro GI: Cyclin-dependent kinase pathways as targets for cancer treatment. J Clin Oncol 24: 1770-1783, 2006.
20. Sherr CJ and Roberts JM: Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 9: 1149-1163, 1995.
21. Sherr CJ: Cancer cell cycles. Science 274: 1672-1677, 1996.
22. Pestell RG, Albanese C, Reutens AT, Segall JE, Lee RJ and Arnold A: The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation. Endocr Rev 20: 501-534, 1999. (Pubitemid 30647078)
23. Grabsch H, Lickvers K, Hansen O, et al: Prognostic value of cyclin B1 protein expression in colorectal cancer. Am J Clin Pathol 122: 511-516, 2004. (Pubitemid 39281246)
24. Rieder CL, Schultz A, Cole R and Sluder G: Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle. J Cell Biol 127: 1301-1310, 1994. (Pubitemid 24362564)
25. Kim EK, Kwon KB, Han MJ, et al: Induction of G1 arrest and apoptosis by Scutellaria barbata in the human promyelocytic leukemia HL-60 cell line. Int J Mol Med 20: 123-128, 2007.
26. Don MJ, Chang YH, Chen KK, Ho LK and Chau YP: Induction of CDK inhibitors (p21(WAF1) and p27(Kip1)) and Bak in the beta-lapachone-induced apoptosis of human prostate cancer cells. Mol Pharmacol 59: 784-794, 2001.
27. Bacci G, Longhi A, Versari M, Mercuri M, Briccoli A and Picci P: Prognostic factors for osteosarcoma of the extremity treated with neoadjuvant chemotherapy: 15-year experience in 789 patients treated at a single institution. Cancer 106: 1154-1161, 2006.