Synthesis and evaluation of 5-fluoro-2-aryloxazolo[5,4- b ]pyridines as β-amyloid PET ligands and identification of MK-3328

ACS Medicinal Chemistry Letters

Volumn 2, Issue 7, 2011, Pages 498-502

  Harrison, Scott T ^a   Mulhearn, James ^a   Wolkenberg, Scott E ^a   Miller, Patricia J ^a   O'Malley, Stacey S ^a   Zeng, Zhizhen ^a   Williams Jr , David L ^a   Hostetler, Eric D ^a   Sanabria Bohórquez, Sandra ^a   Gammage, Linda ^a   Fan, Hong ^a   Sur, Cyrille ^a   Culberson, J Christopher ^a   Hargreaves, Richard J ^a   Cook, Jacquelynn J ^a   Hartman, George D ^a   Barrow, James C ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

amyloid plaque; Alzheimer's disease; fluorine 18; oxazolo 5,4 b pyridine; PET; positron emission tomography

Indexed keywords

5 FLUORO 2 ARYLOXAZOLO[5,4 B]PYRIDINE; FLUORINE 18; MK 3328; PYRIDINE DERIVATIVE; RADIOLIGAND; UNCLASSIFIED DRUG;

AMYLOID PLAQUE; ARTICLE; BINDING ASSAY; BRAIN HOMOGENATE; CLINICAL ASSESSMENT; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; IN VITRO STUDY; ISOTOPE LABELING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL;

EID: 79960393178     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml200018n     Document Type: Article

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