Analgesic and nonsteroidal anti-inflammatory use in relation to nonmelanoma skin cancer: A population-based case-control study

Journal of the American Academy of Dermatology

Volumn 65, Issue 2, 2011, Pages 304-312

  Torti, Dorothea C ^a   Christensen, Brock C ^b   Storm, Craig A ^c   Fortuny, Joan ^d   Perry, Ann E ^c   Zens, Michael S ^c   Stukel, Therese ^c,e   Spencer, Steven K ^a   Nelson, Heather H ^f   Karagas, Margaret R ^c  

^a DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

^b BROWN UNIVERSITY   (United States)

^c DARTMOUTH MEDICAL SCHOOL   (United States)

^d Global Epidemiology   (Spain)

^e INSTITUTE FOR CLINICAL EVALUATIVE SCIENCES   (Canada)

^f UNIVERSITY OF MINNESOTA   (United States)

Author keywords

basal cell carcinoma; case control study; nonmelanoma skin cancer; nonsteroidal anti inflammatory drug; p53; PTCH; squamous cell carcinoma

Indexed keywords

ACETYLSALICYLIC ACID; DICLOFENAC; IBUPROFEN; PARACETAMOL; PROTEIN P53; PROTEIN PATCHED;

ACTINIC KERATOSIS; ADULT; AGED; ARTICLE; BASAL CELL CARCINOMA; CANCER PAIN; CANCER RISK; CIGARETTE SMOKING; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; POPULATION BASED CASE CONTROL STUDY; PRIORITY JOURNAL; PROTEIN POLYMORPHISM; SQUAMOUS CELL CARCINOMA; TREATMENT DURATION;

ACETAMINOPHEN; ADULT; AGE DISTRIBUTION; AGED; ANALGESICS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; CARCINOMA, BASAL CELL; CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; COHORT STUDIES; CONFIDENCE INTERVALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; FOLLOW-UP STUDIES; HUMANS; INCIDENCE; MALE; MIDDLE AGED; ODDS RATIO; REFERENCE VALUES; SEX DISTRIBUTION; SKIN NEOPLASMS;

EID: 79960390257     PISSN: 01909622     EISSN: 10976787     Source Type: Journal    
DOI: 10.1016/j.jaad.2010.05.042     Document Type: Article

References (27)

1. D.S. Rigel, R.J. Friedman, and A.W. Kopf Lifetime risk for development of skin cancer in the US population: current estimate is now 1 in 5 J Am Acad Dermatol 35 1996 1012 1013 (Pubitemid 26422139)
2. J. Scotto, T.R. Fears, K.H. Kraemer, and J.F. Fraumeni Nonmelanoma skin cancer D. Scottenfeld, J.F. Fraumeni, Cancer epidemiology and prevention 1996 Oxford University Press New York 1313 1330
3. V. Marigo, R.A. Davey, Y. Zuo, J.M. Cunningham, and C.J. Tabin Biochemical evidence that patched is the hedgehog receptor Nature 384 1996 176 179 (Pubitemid 26386474)
4. A.E. Bale, and K.P. Yu The hedgehog pathway and basal cell carcinomas Hum Mol Genet 10 2001 757 762 (Pubitemid 32331585)
5. R.J. Gorlin Nevoid basal cell carcinoma syndrome Dermatol Clin 13 1995 113 125
6. H. Danaee, M.R. Karagas, K.T. Kelsey, A.E. Perry, and H.H. Nelson Allelic loss at Drosophila patched gene is highly prevalent in basal and squamous cell carcinomas of the skin J Invest Dermatol 126 2006 1152 1158
7. A. Vazquez, E.E. Bond, A.J. Levine, and G.L. Bond The genetics of the p53 pathway, apoptosis and cancer therapy Nat Rev Drug Discov 7 2008 979 987
8. H. Backvall, A. Asplund, A. Gustafsson, A. Sivertsson, J. Lundeberg, and F. Ponten Genetic tumor archeology: microdissection and genetic heterogeneity in squamous and basal cell carcinoma Mutat Res 571 2005 65 79 (Pubitemid 40313433)
9. P. Kramata, Y.P. Lu, Y.R. Lou, R.N. Singh, S.M. Kwon, and A.H. Conney Patches of mutant p53-immunoreactive epidermal cells induced by chronic UVB irradiation harbor the same p53 mutations as squamous cell carcinomas in the skin of hairless SKH-1 mice Cancer Res 65 2005 3577 3585 (Pubitemid 40616333)
10. C.M. Ulrich, J. Bigler, and J.D. Potter Non-steroidal anti-inflammatory drugs for cancer prevention: promise, perils and pharmacogenetics Nat Rev Cancer 6 2006 130 140 (Pubitemid 43361545)
11. T. Nijsten, C.G. Colpaert, P.B. Vermeulen, A.L. Harris, E. Van Marck, and J. Lambert Cyclooxygenase-2 expression and angiogenesis in squamous cell carcinoma of the skin and its precursors: a paired immunohistochemical study of 35 cases Br J Dermatol 151 2004 837 845 (Pubitemid 39482118)
12. W.B. Bair III, N. Hart, J. Einspahr, G. Liu, Z. Dong, and D. Alberts Inhibitory effects of sodium salicylate and acetylsalicylic acid on UVB-induced mouse skin carcinogenesis Cancer Epidemiol Biomarkers Prev 11 2002 1645 1652 (Pubitemid 36020019)
13. S.M. Fischer Is cyclooxygenase-2 important in skin carcinogenesis? J Environ Pathol Toxicol Oncol 21 2002 183 191 (Pubitemid 34655039)
14. K. Gebauer, P. Brown, and G. Varigos Topical diclofenac in hyaluronan gel for the treatment of solar keratoses Australas J Dermatol 44 2003 40 43 (Pubitemid 36246421)
15. C. Nelson, D. Rigel, S. Smith, N. Swanson, J. Wolf, and I.V. Phase open-label assessment of the treatment of actinic keratosis with 3.0% diclofenac sodium topical gel (Solaraze) J Drugs Dermatol 3 2004 401 407
16. J.K. Rivers, and D.I. McLean An open study to assess the efficacy and safety of topical 3% diclofenac in a 2.5% hyaluronic acid gel for the treatment of actinic keratoses Arch Dermatol 133 1997 1239 1242 (Pubitemid 27443816)
17. G.J. Butler, R. Neale, A.C. Green, N. Pandeya, and D.C. Whiteman Nonsteroidal anti-inflammatory drugs and the risk of actinic keratoses and squamous cell cancers of the skin J Am Acad Dermatol 53 2005 966 972 (Pubitemid 41677321)
18. M.C. Clouser, D.J. Roe, J.A. Foote, and R.B. Harris Effect of non-steroidal anti-inflammatory drugs on non-melanoma skin cancer incidence in the SKICAP-AK trial Pharmacoepidemiol Drug Saf 18 2009 276 283
19. M.V. Grau, J.A. Baron, B. Langholz, M. Karagas, E.R. Greenberg, and T.A. Stukel Effect of NSAIDs on the recurrence of nonmelanoma skin cancer Int J Cancer 119 2006 682 686 (Pubitemid 43955724)
20. A. Kricker, B.K. Armstrong, and D.R. English Sun exposure and non-melanocytic skin cancer Cancer Causes Control 5 1994 367 392 (Pubitemid 24205565)
21. A. Kricker, B.K. Armstrong, D.R. English, and P.J. Heenan Pigmentary and cutaneous risk factors for non-melanocytic skin cancer-a case-control study Int J Cancer 48 1991 650 662
22. J. Toguchida, T. Yamaguchi, B. Ritchie, R.L. Beauchamp, S.H. Dayton, and G.E. Herrera Mutation spectrum of the p53 gene in bone and soft tissue sarcomas Cancer Res 52 1992 6194 6199
23. J. Louhelainen, E. Lindstrom, K. Hemminki, and R. Toftgard Dinucleotide repeat polymorphism within the tumor suppressor gene PTCH at 9q22 Clin Genet 54 1998 239 241 (Pubitemid 28425375)
24. K. Subbaramaiah, N. Altorki, W.J. Chung, J.R. Mestre, A. Sampat, and A.J. Dannenberg Inhibition of cyclooxygenase-2 gene expression by p53 J Biol Chem 274 1999 10911 10915
25. O. Gallo, N. Schiavone, L. Papucci, I. Sardi, L. Magnelli, and A. Franchi Down-regulation of nitric oxide synthase-2 and cyclooxygenase-2 pathways by p53 in squamous cell carcinoma Am J Pathol 163 2003 723 732 (Pubitemid 36909433)
26. J. Leong, M. Hughes-Fulford, N. Rakhlin, A. Habib, J. Maclouf, and M.E. Goldyne Cyclooxygenases in human and mouse skin and cultured human keratinocytes: association of COX-2 expression with human keratinocyte differentiation Exp Cell Res 224 1996 79 87 (Pubitemid 26116890)
27. N.V. Chandrasekharan, H. Dai, K.L. Roos, N.K. Evanson, J. Tomsik, and T.S. Elton COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression Proc Natl Acad Sci U S A 99 2002 13926 13931 (Pubitemid 35215482)