Association of mitochondrial lysyl-tRNA synthetase with HIV-1 GagPol involves catalytic domain of the synthetase and transframe and integrase domains of pol

Journal of Molecular Biology

Volumn 410, Issue 5, 2011, Pages 875-886

  Kobbi, Lydia ^a   Octobre, Guillaume ^a   Dias, José ^a   Comisso, Martine ^a   Mirande, Marc ^a  

^a LABORATOIRE D ENZYMOLOGIE ET BIOCHIMIE STRUCTURALES   (France)

Author keywords

cellular routing; HIV 1; lysyl tRNA synthetase; tRNA packaging

Indexed keywords

GAG PROTEIN; GAGPOL POLYPROTEIN; INTEGRASE; LYSINE TRANSFER RNA LIGASE; MITOGEN ACTIVATED PROTEIN KINASE P38; POL PROTEIN; POLYPROTEIN; SCAFFOLD PROTEIN; SYNTHETASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CYTOPLASM; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; IN VIVO STUDY; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; VIRION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 79960369440     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2011.03.005     Document Type: Article

References (27)

1. Abbink T.E.; and Berkhout B. HIV-1 reverse transcription initiation: a potential target for novel antivirals? Virus Res. 134 2008 4 18
2. Jiang M.; Mak J.; Ladha A.; Cohen E.; Klein M.; Rovinski B.; and Kleiman L. Identification of tRNAs incorporated into wild-type and mutant human immunodeficiency virus type-1 J. Virol. 67 1993 3246 3253 (Pubitemid 23143696)
3. Lys into human immunodeficiency virus type 1 particles J. Virol. 68 1994 2065 2072
4. Cen S.; Khorchid A.; Javanbakht H.; Gabor J.; Stello T.; and Shiba K. Incorporation of lysyl-tRNA synthetase into human immunodeficiency virus type 1 J. Virol. 75 2001 5043 5048 (Pubitemid 32448525)
5. Francin M.; Kaminska M.; Kerjan P.; and Mirande M. The N-terminal domain of mammalian lysyl-tRNA synthetase is a functional tRNA-binding domain J. Biol. Chem. 277 2002 1762 1769 (Pubitemid 34968747)
6. Francin M.; and Mirande M. Functional dissection of the eukaryotic-specific tRNA-interacting factor of lysyl-tRNA synthetase J. Biol. Chem. 278 2003 1472 1479 (Pubitemid 36801373)
7. Mirande M. Processivity of translation in the eukaryote cell: role of aminoacyl-tRNA synthetases FEBS Lett. 584 2010 443 447
8. Lys incorporation into human immunodeficiency virus type 1 J. Virol. 78 2004 1595 1601 (Pubitemid 38095869)
9. Tolkunova E.; Park H.; Xia J.; King M.P.; and Davidson E. The human lysyl-tRNA synthetase gene encodes both the cytoplasmic and mitochondrial enzymes by means of an unusual alternative splicing of the primary transcript J. Biol. Chem. 275 2000 35063 35069
10. Kaminska M.; Shalak V.; Francin M.; and Mirande M. Viral hijacking of mitochondrial lysyl-tRNA synthetase J. Virol. 81 2007 68 73 (Pubitemid 44975147)
11. Mirande M. Multi-aminoacyl-tRNA synthetase complexes M. Ibba, C. Francklyn, S. Cusack, The Aminoacyl-tRNA Synthetases 2005 Landes Bioscience Georgetown, TX 298 308
12. Lys concentration in human immunodeficiency virus type 1 upon its annealing to viral RNA, GagPol incorporation, and viral infectivity J. Virol. 76 2002 9096 9102 (Pubitemid 34919868)
13. Javanbakht H.; Halwani R.; Cen S.; Saadatmand J.; Musier-Forsyth K.; Gottlinger H.; and Kleiman L. The interaction between HIV-1 Gag and human lysyl-tRNA synthetase during viral assembly J. Biol. Chem. 278 2003 27644 27651 (Pubitemid 36899951)
14. Lys packaging/annealing complex Virology 380 2008 109 117
15. Kovaleski B.J.; Kennedy R.; Hong M.K.; Datta S.A.; Kleiman L.; Rein A.; and Musier-Forsyth K. In vitro characterization of the interaction between HIV-1 Gag and human lysyl-tRNA synthetase J. Biol. Chem. 281 2006 19449 19456 (Pubitemid 44035449)
16. Kaminska M.; Havrylenko S.; Decottignies P.; Le Marechal P.; Negrutskii B.; and Mirande M. Dynamic organization of aminoacyl-tRNA synthetase complexes in the cytoplasm of human cells J. Biol. Chem. 284 2009 13746 13754
17. Gyuris J.; Golemis E.; Chertkov H.; and Brent R. Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2 Cell 75 1993 791 803 (Pubitemid 23346376)
18. Kaminska M.; Havrylenko S.; Decottignies P.; Gillet S.; Marechal P.L.; Negrutskii B.; and Mirande M. Dissection of the structural organization of the aminoacyl-tRNA synthetase complex J. Biol. Chem. 284 2009 6053 6060
19. Robinson J.C.; Kerjan P.; and Mirande M. Macromolecular assemblage of aminoacyl-tRNA synthetases: quantitative analysis of protein-protein interactions and mechanism of complex assembly J. Mol. Biol. 304 2000 983 994 (Pubitemid 32047095)
20. Quevillon S.; Robinson J.C.; Berthonneau E.; Siatecka M.; and Mirande M. Macromolecular assemblage of aminoacyl-tRNA synthetases: Identification of protein-protein interactions and characterization of a core protein J. Mol. Biol. 285 1999 183 195 (Pubitemid 29034036)
21. Arion D.; Harada R.; Li X.G.; Wainberg M.A.; and Parniak M.A. HIV-1 reverse transcriptase shows no specificity for the binding of primer tRNA(Lys3) Biochem. Biophys. Res. Commun. 225 1996 839 843 (Pubitemid 26319192)
22. Zhu K.; Dobard C.; and Chow S.A. Requirement for integrase during reverse transcription of human immunodeficiency virus type 1 and the effect of cysteine mutations of integrase on its interactions with reverse transcriptase J. Virol. 78 2004 5045 5055 (Pubitemid 38581456)
23. Pavon-Eternod M.; Wei M.; Pan T.; and Kleiman L. Profiling non-lysyl tRNAs in HIV-1 RNA 16 2010 267 273
24. Gampel A.; and Tzagoloff A. Homology of aspartyl- and lysyl-tRNA synthetases Proc. Natl Acad. Sci. USA 86 1989 6023 6027 (Pubitemid 19210594)
25. Cirakoglu B.; and Waller J.P. Leucyl-tRNA and lysyl-tRNA synthetases, derived from the high-Mr complex of sheep liver, are hydrophobic proteins Eur. J. Biochem. 151 1985 101 110 (Pubitemid 15226650)
26. Mirande M.; Cirakoglu B.; and Waller J.P. Macromolecular complexes from sheep and rabbit containing seven aminoacyl-tRNA synthetases. III. Assignment of aminoacyl-tRNA synthetase activities to the polypeptide components of the complexes J. Biol. Chem. 257 1982 11056 11063
27. Golinelli-Cohen M.P.; Zakrzewska A.; and Mirande M. Complementation of yeast Arc1p by the p43 component of the human multisynthetase complex does not require its association with yeast MetRS and GluRS J. Mol. Biol. 340 2004 15 27 (Pubitemid 38739434)