Phenylpropenamide derivatives: Anti-hepatitis B virus activity of the Z isomer, SAR and the search for novel analogs

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 15, 2011, Pages 4642-4647

  Wang, Peiyuan ^a   Naduthambi, Devan ^a   Mosley, Ralph T ^a   Niu, Congrong ^a   Furman, Phillip A ^a   Otto, Michael J ^a   Sofia, Michael J ^a  

^a PHARMASSET INC   (United States)

Author keywords

Antivirals; HBV inhibitors; Hepatitis B virus; Phenylpropenamides; Pregenomic RNA packaging

Indexed keywords

NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PHENYLPROPANOLAMINE;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; HEPATITIS B; ISOMER; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; X RAY CRYSTALLOGRAPHY;

AMIDES; ANTIVIRAL AGENTS; CELL LINE; CRYSTALLOGRAPHY, X-RAY; HEPATITIS B VIRUS; HUMANS; ISOMERISM; MOLECULAR CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

HEPATITIS B VIRUS;

EID: 79960369208     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.05.077     Document Type: Article

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