Fitness and fatness are independently associated with markers of insulin resistance in European adolescents; The HELENA Study

International Journal of Pediatric Obesity

Volumn 6, Issue 3-4, 2011, Pages 253-260

  Jiménez Pavón, David ^a,b   Castillo, Manuel J ^a   Moreno, Luis A ^c   Kafatos, Anthony ^d   Manios, Yannis ^e   Kondaki, Katerine ^e   Béghin, Laurent ^f   Zaccaria, Maria ^g   De Henauw, Stefaan ^h   Widhalm, Kurt ⁱ   Molnár, Dénes ^j   Sjöström, Michael ^k   González Gross, Marcela ^b   Ruiz, Jonatan R ^a,k  

^a UNIVERSITY OF GRANADA   (Spain)

^b UNIVERSIDAD POLITÉCNICA DE MADRID   (Spain)

^c UNIVERSITY OF ZARAGOZA   (Spain)

^d UNIVERSITY OF CRETE   (Greece)

^e HAROKOPIO UNIVERSITY   (Greece)

^f UNIV LILLE   (France)

^g ISTITUTO NAZIONALE DELLA NUTRIZIONE   (Italy)

^h GHENT UNIVERSITY   (Belgium)

ⁱ MEDICAL UNIVERSITY OF VIENNA   (Austria)

^j UNIVERSITY OF PÉCS   (Hungary)

^k KAROLINSKA INSTITUTE   (Sweden)

more..

Author keywords

Cardiorespiratory fitness; Glucose; HOMA; Insulin; Total and central body fat

Indexed keywords

GLUCOSE; INSULIN;

ADOLESCENT; ARTICLE; BODY FAT; BODY HEIGHT; BODY MASS; BODY WEIGHT; CARDIOPULMONARY FUNCTION; CHILD; DISEASE MARKER; EUROPE; FEMALE; FITNESS; HOMEOSTASIS; HUMAN; INSULIN RESISTANCE; MALE; PRIORITY JOURNAL; PUBERTY; SCHOOL CHILD; SKINFOLD THICKNESS; WAIST CIRCUMFERENCE;

ADIPOSITY; ADOLESCENT; AGE FACTORS; ANALYSIS OF VARIANCE; BLOOD GLUCOSE; BODY HEIGHT; BODY MASS INDEX; BODY WEIGHT; CROSS-SECTIONAL STUDIES; EUROPE; EXERCISE TEST; FEMALE; HEALTH SURVEYS; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; OBESITY; PHYSICAL FITNESS; REGRESSION ANALYSIS; SKINFOLD THICKNESS; WAIST CIRCUMFERENCE;

EID: 79960341951     PISSN: 17477166     EISSN: 17477174     Source Type: Journal    
DOI: 10.3109/17477166.2011.575158     Document Type: Article

References (37)

1. Karam JG, McFarlane SI. Prevention of type 2 DM: implications for adolescents and young adults. Pediatr Endocrinol Rev. 2008;5(Suppl. 4):980-8.
2. Hale DE. Type 2 diabetes and diabetes risk factors in children and adolescents. Clin Cornerstone. 2004;6(2):17-30.
3. Srinivasan SR, Myers L, Berenson GS. Predictability of childhood adiposity and insulin for developing insulin resistance syndrome (syndrome X) in young adulthood: the Bogalusa Heart Study. Diabetes. 2002;51(1):204-9. (Pubitemid 34517999)
4. Ruiz JR, Rizzo NS, Hurtig-Wennlof A, Ortega FB, Warnberg J, Sjostrom M. Relations of total physical activity and intensity to fitness and fatness in children: the European Youth Heart Study. Am J Clin Nutr. 2006;84(2):299-303. (Pubitemid 44699137)
5. Ortega FB, Ruiz JR, Castillo MJ, Sjostrom M. Physical fitness in childhood and adolescence: a powerful marker of health. Int J Obes (Lond). 2008;32(1):1-11.
6. Ruiz JR, Rizzo NS, Ortega FB, Loit HM, Veidebaum T, Sjostrom M. Markers of insulin resistance are associated with fatness and fitness in school-aged children: the European Youth Heart Study. Diabetologia. 2007;50(7):1401-8. (Pubitemid 46879007)
7. Allen DB, Nemeth BA, Clark RR, Peterson SE, Eickhoff J, Carrel AL. Fitness is a stronger predictor of fasting insulin levels than fatness in overweight male middle-school children. J Pediatr. 2007;150(4):383-7. (Pubitemid 46428305)
8. Bell LM, Watts K, Siafarikas A et al. Exercise alone reduces insulin resistance in obese children independently of changes in body composition. J Clin Endocrinol Metab. 2007;92(11): 4230-5. (Pubitemid 350074736)
9. Carrel AL, McVean JJ, Clark RR, Peterson SE, Eickhoff JC, Allen DB. School-based exercise improves fitness, body composition, insulin sensitivity, and markers of inflammation in non-obese children. J Pediatr Endocrinol Metab. 2009; 22(5):409-15.
10. Cummings DM, Dubose KD, Imai S, Collier DN. Fitness versus fatness and insulin resistance in U.S. adolescents. J Obes. 2010; (Epub online doi:10.1155/2010/195729:0-7).
11. Imperatore G, Cheng YJ, Williams DE, Fulton J, Gregg EW. Physical activity, cardiovascular fitness, and insulin sensitivity among U.S. adolescents: the National Health and Nutrition Examination Survey, 1999-2002. Diabetes Care. 2006; 29(7):1567-72. (Pubitemid 44127582)
12. Puder JJ, Schindler C, Zahner L, Kriemler S. Adiposity, fitness and metabolic risk in children: a cross-sectional and longitudinal study. Int J Pediatr Obes. 2010 Nov 22. [Epub ahead of print].
13. Andersen LB, Sardinha LB, Froberg K, Riddoch CJ, Page AS, Anderssen SA. Fitness, fatness and clustering of cardiovascular risk factors in children from Denmark, Estonia and Portugal: the European Youth Heart Study. Int J Pediatr Obes. 2008;3(Suppl. 1):58-66. (Pubitemid 351285469)
14. Ruiz JR, Castro-Pinero J, Artero EG, et al. Predictive validity of health-related fitness in youth: a systematic review. Br J Sports Med. 2009;43(12):909-23.
15. Carrel AL, Allen DB. The influence of fitness on insulin resistance in obese children. Rev Endocr Metab Disord. 2009;10(3):189-96.
16. Stumvoll M, Goldstein BJ, van Haeften TW. Type 2 diabetes: principles of pathogenesis and therapy. Lancet. 2005;365 (9467):1333-46.
17. Moreno LA, De Henauw S, Gonzalez-Gross M et al. Design and implementation of the Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-Sectional Study. Int J Obes (Lond). 2008;32(Suppl. 5):S4-11.
18. Moreno LA, Gonzalez-Gross M, Kersting M et al. Assessing, understanding and modifying nutritional status, eating habits and physical activity in European adolescents: the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study. Public Health Nutr. 2008;11(3):288-99. (Pubitemid 351214500)
19. Beghin L, Castera M, Manios Y et al. Quality assurance of ethical issues and regulatory aspects relating to good clinical practices in the HELENA Cross-Sectional Study. Int J Obes (Lond). 2008;32(Suppl. 5):S12-8.
20. Nagy E, Vicente-Rodriguez G, Manios Y et al. Harmonization process and reliability assessment of anthropometric measurements in a multicenter study in adolescents. Int J Obes (Lond). 2008;32(Suppl. 5):S58-65.
21. Lohman TG, Roche AF, Martorell R. Anthropometric Standardization Reference Manual. Champaign, IL: Human Kinetics Books; 1988.
22. Tanner JM, Whitehouse RH. Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Arch Dis Child. 1976;51(3):170-9.
23. Gonzalez-Gross M, Breidenassel C, Gomez-Martinez S et al. Sampling and processing of fresh blood samples within a European multicenter nutritional study: evaluation of biomarker stability during transport and storage. Int J Obes (Lond). 2008;32(Suppl. 5):S66-75.
24. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985; 28(7):412-9 (Pubitemid 15018832)
25. Léger L, Lambert J, Goulet A, Rowan C, Dinelle Y. Aerobic capacity of 6 to 17-year-old Quebecois-20 meter shuttle run test with 1 minute stages. Can J Appl Sport Sci. 1984; 9(2):64-9.
26. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ. 2000;320(7244):1240-3. (Pubitemid 30240471)
27. Cole TJ, Flegal KM, Nicholls D, Jackson AA. Body mass index cut offs to define thinness in children and adolescents: international survey. BMJ. 2007;335(7612):194.
28. Ruiz JR, Ramirez-Lechuga J, Ortega FB et al. Artificial neural network-based equation for estimating VO2max from the 20 m shuttle run test in adolescents. Artif Intell Med. 2008;44(3):233-45.
29. Hirst K, Baranowski T, DeBar L et al. HEALTHY study rationale, design and methods: moderating risk of type 2 diabetes in multi-ethnic middle school students. Int J Obes (Lond). 2009;33(Suppl. 4):S4-20.
30. Bacha F, Saad R, Gungor N, Arslanian SA. Are obesity-related metabolic risk factors modulated by the degree of insulin resistance in adolescents? Diabetes Care. 2006;29(7): 1599-604. (Pubitemid 44127587)
31. Raman A, Fitch MD, Hudes ML et al. Baseline correlates of insulin resistance in inner city high-BMI African-American children. Obesity (Silver Spring). 2008;16(9):2039-45.
32. Ball GD, Shaibi GQ, Cruz ML, Watkins MP, Weigensberg MJ, Goran MI. Insulin sensitivity, cardiorespiratory fitness, and physical activity in overweight Hispanic youth. Obes Res. 2004;12(1):77-85. (Pubitemid 41137490)
33. Dunger DB, Ahmed ML, Ong KK. Effects of obesity on growth and puberty. Best Pract Res Clin Endocrinol Metab. 2005;19(3):375-90. (Pubitemid 41263793)
34. Burt Solorzano CM, McCartney CR. Obesity and the puber-tal transition in girls and boys. Reproduction. 2010;140(3): 399-410.
35. Kelly LA, Lane CJ, Weigensberg MJ, Toledo-Corral CM, Goran MI. Pubertal changes of insulin sensitivity, acute insulin response, and SS-cell function in overweight Latino youth. J Pediatr. 2011;158(3):442-6.
36. Cruz ML, Shaibi GQ, Weigensberg MJ, Spruijt-Metz D, Ball GD, Goran MI. Pediatric obesity and insulin resistance: chronic disease risk and implications for treatment and prevention beyond body weight modification. Annu Rev Nutr. 2005;25:435-68. (Pubitemid 41209009)
37. Shaibi GQ, Ball GD, Cruz ML, Weigensberg MJ, Salem GJ, Goran MI. Cardiovascular fitness and physical activity in children with and without impaired glucose tolerance. Int J Obes (Lond). 2006;30(1):45-9. (Pubitemid 41790776)