Nitrogen starvation of cyanobacteria results in the production of β-N-methylamino-L-alanine

Toxicon

Volumn 58, Issue 2, 2011, Pages 187-194

  Downing, S ^a   Banack, S A ^b   Metcalf, J S ^b   Cox, P A ^b   Downing, T G ^a  

^a NELSON MANDELA METROPOLITAN UNIVERSITY   (South Africa)

^b Institute for Ethnomedicine   (United States)

Author keywords

Cyanobacteria; Ecophysiology; Metabolism; Toxin

Indexed keywords

2 AMINO 3 METHYLAMINOPROPIONIC ACID; ALANINE; AMMONIA; ARGININE; ASPARAGINE; GLUTAMIC ACID; GLUTAMINE; NITRATE; NITROGEN; NITROGEN 15; SERINE; VALINE;

AMINO ACID SYNTHESIS; ARTICLE; BACTERIAL CELL; BACTERIUM CULTURE; CATABOLISM; CONTROLLED STUDY; CULTURE MEDIUM; ISOTOPE LABELING; MICROCYSTIS; NONHUMAN; PRIORITY JOURNAL; SYNECHOCYSTIS;

AMINO ACIDS, DIAMINO; AMMONIA; AXENIC CULTURE; BACTERIAL TOXINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYANOBACTERIA; MARINE TOXINS; MICROCYSTIS; NEUROTOXINS; NITRATES; NITROGEN; NITROGEN ISOTOPES; SPECIES SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STATISTICS AS TOPIC; SYNECHOCYSTIS; TANDEM MASS SPECTROMETRY; TIME FACTORS;

CYANOBACTERIA;

EID: 79960320533     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2011.05.017     Document Type: Article

References (26)

1. Araoz R., Molgó J., Tandeau de Marsac N. Neurotoxic cyanobacterial toxins. Toxicon 2010, 56:813-828.
2. Banack S.A., Johnson H.E., Cheng R., Cox P.A. Production of the neurotoxin BMAA by a marine cyanobacterium. Mar. Drugs 2007, 5:180-196.
3. Banack S.A., Downing T.G., Spáčil Z., Purdie E.L., Metcalf J.S., Downing S., Esterhuizen M., Codd G.A., Cox P.A. Distinguishing the cyanobacterial neurotoxin β-N-methylamino-L-alanine (BMAA) from its structural isomer 2,4-diamino butyric acid (2,4-DAB). Toxicon 2010, 56:868-879.
4. Banack S.A., Metcalf J.S., Spáčil Z., Downing T.G., Downing S., Long A., Nunn P.B., Cox P.A. Distinguishing the cyanobacterial neurotoxin β-N-methylamino-L-alanine (BMAA) from other diamino acids. Toxicon 2011, 10.1016/j.toxicon.2011.02.005.
5. Brenner E.D., Martinez-Barboza N., Clark A.P., Liang Q.S., Stevenson D.W., Coruzzi G.M. Arabidopsis mutants resistant to S(+)-beta-methyl-alpha, beta-diaminopropionic acid, a cycad-derived glutamate receptor agonist. Plant Physiol. 2000, 124:1615-1624.
6. Brenner E.D., Stevenson D.W., McCombie R.W., Katari M.S., Rudd S.A., Mayer K.F.X., Palenchar P.M., Runko S.J., Twigg R.W., Dai G., Martienssen R.A., Benfey P.N., Coruzzi G.M. Expressed sequence tag analysis in Cycas, the most primitive living seed plant. Genome Biol. 2003, 4:R78.
7. Bidigare R.R., Christensen S.J., Wilde S.B., Banack S.A. Cyanobacteria and BMAA: possible linkage with avian vacuolar myelinopathy (AVM) in the south-eastern United States. Amyotroph. Lateral Scler. 2009, 10(S2):71-73.
8. Cox P.A., Banack S.A., Murch S.J., Rasmussen U., Tien G., Bidigare R.R., Metcalf J.S., Morrison L.F., Codd G.A., Bergman B. Diverse taxa of cyanobacteria produce β-N-methylamino-L-alanine, a neurotoxic amino acid. Proc. Natl. Acad. Sci. USA 2005, 102:5074-5078.
9. Esterhuizen M., Downing T.G. β-N-methylamino-L-alanine (BMAA) in novel South African cyanobacterial isolates. Ecotoxicol. Environ. Saf. 2008, 71:309-313.
10. Esterhuizen M., Downing S., Downing T.G. Improved sensitivity using liquid chromotagraphy mass spectrometry (LC-MS) for the detection of propyl chloroformate derivatised β-N-methylamino-L-alanine (BMAA) in cyanobacteria. Water SA 2011, 37:1-6.
11. Esterhuizen M., Pflugmacher S., Downing T.G. β-N-methylamino-L-alanine (BMAA) uptake by the aquatic macrophyte Ceratophyllum demersum. Ecotoxicol. Environ. Saf. 2011, 74:74-77.
12. Esterhuizen M., Pflugmacher S., Downing T.G. The effect of β-N-methylamino-L-alanine (BMAA) on oxidative stress response enzymes of the macrophyte Ceratophyllum demersum. Toxicon 2011, 57:803-810.
13. Faassen E.J., Gillissen F., Zweers J., Lürling M. Determination of the neurotoxins BMAA (β-N-methylamino-L-alanine) and DAB (α-γ-diaminobutyric acid) by LC-MSMS in Dutch urban waters with cyanobacterial blooms. Amyotroph. Lateral Scler. 2009, 10(S2):79-84.
14. Krüger T., Mönch B., Oppenhäuser S., Luckas B. LC-MS/MS determination of the isomeric neurotoxins BMAA (β-N-Methylamino-L-Alanine) and DAB (2,4-diamino butyric acid) in cyanobacteria and seeds of Cycas revoluta and Lathyrus latifolius. Toxicon 2010, 55:547-557.
15. Liu X., Rush T., Zapata J., Lobner D. β-N-methylamino-L-alanine induces oxidative stress and glutamate release through action on system Xc- Exp. Neurol. 2009, 217:429-433.
16. Lobner D., Piana P.M.T., Salous A.K., Peoples R.W. β-N-methylamino-L-alanine enhances neurotoxicity through multiple mechanisms. Neurobiol. Dis. 2007, 25:360-366.
17. Metcalf J.S., Banack S.A., Lindsay J., Morrison L.F., Cox P.A., Codd G.A. Co-occurrence of β-N-methylamino-L-alanine, a neurotoxic amino acid with other cyanobacterial toxins in British waterbodies 1990-2004. Environ. Microbiol. 2008, 10:702-708.
18. Murch S.J., Cox P.A., Banack S.A. A mechanism for slow release of biomagnified cyanobacterial neurotoxins and neurodegenerative disease in Guam. Proc. Natl. Acad. Sci. USA 2004, 101:12228-12231.
19. Pablo J., Banack S.A., Cox P.A., Johnson T.E., Papapetropoulos S., Bradley W.G., Buck A., Mash D.C. Cyanobacterial neurotoxin BMAA in ALS and Alzheimer's disease. Acta Neurol. Scand 2009, 120:216-225.
20. Purdie E.L., Samsudin S., Eddy F.B., Codd G.A. Effects of the cyanobacterial neurotoxin β-N-methylamino-L-alanine, on the early life stage development of zebrafish (Danio rerio). Aquat. Toxicol. 2009, 95:279-284.
21. Rao S.D., Banack S.A., Cox P.A., Weiss J.H. BMAA selectively injures motor neurons via AMPA/kainate receptor activation. Exp. Neurol. 2006, 201:244-252.
22. Rippka R. Isolation and purification of cyanobacteria. Methods Enzymol. 1988, 167:3-27.
23. Rosén J., Hellenäs K.-E. Determination of the neurotoxin BMAA (β-N-methylamino-L-alanine) in cycad seed and cyanobacteria by LC-MS/MS (liquid chromatography tandem mass spectrometry). Analyst 2008, 133:1785-1789.
24. Spáčil Z., Eriksson J., Jonasson S., Rasmussen U., Ilag L.L., Bergman B. Analytical protocol for identification of BMAA and DAB in biological samples. Analyst 2010, 135:127-132.
25. Sprent A., Smeeton N.C. Applied Nonparametric Statistical Methods 2007, Chapman & Hall, Boca Raton, Florida. fourth ed.
26. Vega A., Bell E.A. α-amino-β-methylaminopropionic acid, a new amino acid from seeds of Cycas circinalis. Phytochemistry 1967, 6:759-762.